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Platelet-Rich Plasma

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Regenerative Medicine for Spine and Joint Pain

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Abstract

Platelet-rich plasma (PRP) is a versatile autologous blood product with regenerative, anti-inflammatory, and anti-microbial properties, derived from the growth factors and cytokines contained and released from platelets concentrated at supraphysiological levels. The basic science of PRP has demonstrated its regenerative and immunomodulatory properties via cell, tissue, and preclinical animal model studies, and clinical interest in translation of these properties has extended rapidly to regenerative medicine applications for musculoskeletal and spine disorders. However, randomized clinical trials of PRP therapy for osteoarthritis and chronic tendinopathy thus far have yielded often contradictory results. Therefore, efforts are underway to define both PRP composition and the underlying pathophysiology of specific disease processes, in order to elucidate the biological targets of PRP therapy and ultimately to improve clinical outcomes.

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Authors and Affiliations

  1. Department of Rehabilitation Medicine, NewYork-Presbyterian Hospital, New York, NY, USA

    Xiaoning (Jenny) Yuan

  2. Department of Rehabilitation Medicine, Weill Cornell Medicine, New York, NY, USA

    Alfred C. Gellhorn

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  1. Xiaoning (Jenny) Yuan
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  2. Alfred C. Gellhorn
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Correspondence to Xiaoning (Jenny) Yuan .

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  1. Princeton Spine and Joint Center, Princeton, NJ, USA

    Grant Cooper

  2. Department of Rehabilitation Medicine, Mount Sinai Hospital, New York, NY, USA

    Joseph Herrera

  3. Princeton Spine and Joint Center, Princeton, NJ, USA

    Jason Kirkbride

  4. Princeton Spine and Joint Center, Princeton, NJ, USA

    Zachary Perlman

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Yuan, X.(., Gellhorn, A.C. (2020). Platelet-Rich Plasma. In: Cooper, G., Herrera, J., Kirkbride, J., Perlman, Z. (eds) Regenerative Medicine for Spine and Joint Pain. Springer, Cham. https://doi.org/10.1007/978-3-030-42771-9_5

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