Abstract
Global interests on functional foods and nutraceuticals have increased enormously in the last decade. This renewed attention stemmed largely from the promised benefits that functional foods and nutraceuticals have on the promotion of health and prevention of illness. People have increasingly become more health conscious which largely drives the growing economy of the health food market today. In this chapter, we review the definition and classification of functional foods. Evidence-based health benefits of a number of popular bioactive components of interest in functional foods and nutraceuticals are also presented. While not as exhaustive, these examples will provide a preview to functional food science and product development as a guide for researchers. The details of the health benefits of various functional foods will be discussed in the succeeding chapters of this book.
Keywords
- Functional foods
- Nutraceuticals
- Types of functional foods
- Health benefits
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References
Azzini E, Giacometti J, Russo GL (2017) Antiobesity Effects of Anthocyanins in Preclinical and Clinical Studies. Oxidative Med Cell Longev 2017:2740364. https://doi.org/10.1155/2017/2740364
Banjarnahor DS, Artnti N (2015) Antioxidant properties of flavonoids. Med J Indones 23(4):239–244
Bertoia ML, Rimm EB, Mukamal KJ, Hu FB, Willett WC (2016) Dietary flavonoid intake and weight maintenance: three prospective cohorts of 124086 US men and women followed for up to 24 years. BMJ 352. https://doi.org/10.1136/bmj.i17
British Nutrition Foundation (2018) Functional foods. Retrieved from https://www.nutrition.org.uk/nutritionscience/foodfacts/functional-foods.html. Available on 1st February, 2019.
Brunetti C, Di Ferdinando M, Fini A, Pollastri S, Tattini M (2013) Flavonoids as antioxidants and developmental regulators: relative significance in plants and humans. Int J Mol Sci 14(2):3540–3555. https://doi.org/10.3390/ijms14023540
Bull E, Rapport L, Lockwood B (2000) What is a nutraceutical? Retrieved from https://www.pharmaceutical-journal.com/1-what-is-a nutraceutical/20002095.article?firstPass=false
CAB reviews perspectives in agriculture veterinary science nutrition and natural resources 5(029). Anthocyanins and weight loss. (2010). https://doi.org/10.1079/PAVSNNR20105029
Cabrera C, Artacho R, Giménez R (2006) Beneficial effects of green tea—a review. J Am Coll Nutr 25(2):79–99
Calvo MS, Whiting SJ (2013) Survey of current vitamin D food fortification practices in the United States and Canada. J Steroid Biochem Mol Biol 136:211–213
Cashman KD (2015) Vitamin D: dietary requirements and food fortification as a means of helping achieve adequate vitamin D status. J Steroid Biochem Mol Biol 148:19–26
Cassidy A, O’Reilly ÉJ, Kay C, Sampson L, Franz M, Forman JP, Curhan G, Rimm EB (2011) Habitual intake of flavonoid subclasses and incident hypertension in adults. Am J Clin Nutr 93:338–347. https://doi.org/10.3945/ajcn.110.006783
Cencic A, Chingwaru W (2010) The Role of Functional Foods, Nutraceuticals, and Food Supplements in Intestinal Health. Nutrients 2(6):611–625
Chen J, Song Y, Zhang L (2013) Effect of lycopene supplementation on oxidative stress: an exploratory systematic review and metaanalysis of randomized controlled trials. J Med Food 16(5):361–374
Chen P, Zhang W, Wang X, Zhao K, Negi DS, Zhuo L, Qi M, Wang X, Zhang X (2015) Lycopene and risk of prostate cancer: a systematic review and meta-analysis. Medicine 94(33):e1260
Cheng HM, Koutsidis G, Lodge JK, Ashor AW, Siervo M, Lara J (2017) Lycopene and tomato and risk of cardiovascular diseases: A systematic review and meta-analysis of epidemiological evidence. Crit Rev Food Sci Nutr 1:1–8
Crowe KM, Francis C (2013) Position of the academy of nutrition and dietetics: functional foods. J Acad Nutr Diet 113(8):1096–1103
Dary O, Hurrell R (2006) Guidelines on food fortification with micronutrients. Switzerland World Health Organization, Food and Agricultural Organization of the United Nations, Geneva
Eufic (2006) What are functional foods and How can they help us? Retrieved from https://www.eufic.org/en/food-production/article/functional-foods.
FAO/WHO (1994) Codex alimentarius, vol 4, 2nd edn
Fogacci F, Tocci G, Presta V, Fratter A, Borghi C, Cicero AF (2018 Jan) Effect of resveratrol on blood pressure: A systematic review and meta-analysis of randomized, controlled, clinical trials. Crit Rev Food Sci Nutr 19:1–4
Food Insight (2009, August) 2009 Functional foods/foods for health consumer trends survey executive summary. Accessed on 29 March 2019. https://foodinsight.org/2009-functional-foods-foods-for-health-consumer-trending-survey-executive-summary-2/
Functional Food Ingredients Market (2018, July) Functional food ingredients market by type (probiotics, prebiotics, proteins & amino acids, phytochemical & plant extracts, omega-3 fatty acids, carotenoids, fibers & specialty carbohydrates), application, source, and region – global forecast to 2023. Accessed on 29 Mar 2019 at https://www.marketsandmarkets.com/Market-Reports/functional-food-ingredients-market-9242020.html
Ganeshpurkara A, Salujaa AK (2017) Neuroprotective effect of Rutin. Saudi Pharm J 25(2):149–164
Grune T, Lietz G, Palou A, Ross AC, Stahl W, Tang G et al (2010) β-carotene is an important vitamin a source for humans. J Nutr 140(12):2268S–2285S. https://doi.org/10.3945/jn.109.119024
Guardia T, Rotelli AE, Juarez AO, Pelzer LE (2001) Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat. Farmaco 56(9):683–687. [PubMed]
Gul K, Tak A, Singh AK, Singh P, Yousuf B, Wani AA (2015) Chemistry, encapsulation, and health benefits of β-carotene – a review. Cogent Food Agric 1:1018696
Gunawardena D, Munch G (2014) Polyphenols in chronic diseases and their mechanisms of action. In: Polyphenols in human health and disease. Academic Press, Amsterdam
Hasler CM (2002) Functional foods: benefits, concerns and challenges—a position paper from the American Council on Science and Health. J Nutr 132(12):3772–3781. https://doi.org/10.1093/jn/132.12.3772
Hasler CM, Brown AC (2009) Position of the American Dietetic Association: functional foods. J Am Diet Assoc 109(4):735–746
Hassellund SS, Flaa A, Sandvik L, Kjeldsen SE, Rostrup M (2012) Effects of anthocyanins on blood pressure and stress reactivity: A double-blind randomized placebo-controlled crossover study. J Hum Hypertens 26:396–404. https://doi.org/10.1038/jhh.2011.41
Hassellund SS, Flaa A, Kjeldsen SE, Seljeflot I, Karlsen A, Erlund I, Rostrup M (2013) Effects of anthocyanins on cardiovascular risk factors and inflammation in pre-hypertensive men: A double-blind randomized placebo-controlled crossover study. J Hum Hypertens 27:100–106. https://doi.org/10.1038/jhh.2012.4
Hoffpauer DW, Wright SL III (1994) Enrichment of rice. In: Marshall WE, Wadsworth JI (eds) Rice science and technology. Marcel Dekker, Inc., New York
Horcajada MN, Sanchez C, Membrez SF, Drion P, Comblain F, Taralla S, Donneau AF, Offord EA, Henrotin Y (2014) Oleuropein or rutin consumption decreases the spontaneous development of osteoarthritis in the Hartley guinea pig. Osteoarthr Cartil 23(1):94–102. https://www.nutrition.org.uk/nutritionscience/foodfacts/functional-foods.html?start=1
Ilic D, Misso M (2012) Lycopene for the prevention and treatment of benign prostatic hyperplasia and prostate cancer: a systematic review. Maturitas 72(4):269–276
Ilic D, Forbes KM, Hassed C (2011) Lycopene for the prevention of prostate cancer. Cochrane Database Syst Rev 11:CD008007
International Food Technologists (2015) Bringing functional foods to market. Retrieved from http://www.ift.org/knowledgecenter/read-ift-publications/science-reports/scientific-status-summaries/functional-foods/bringingfunctional-foods-to-market.aspx
Javed H, Khan MM, Ahmad A, Vaibhav K, Ahmad ME, Khan A, Ashafaq M, Islam F, Siddiqui MS, Safhi MM, Islam F (2012) Rutin prevents cognitive impairments by ameliorating oxidative stress and neuroinflammation in rat model of sporadic dementia of Alzheimer type. Neuroscience 17:340–352
Jennings A, Welch AA, Fairweather-Tait SJ, Kay C, Minihane AM, Chowienczyk P, Jiang B, Cecelja M, Spector T, Macgregor A et al (2012) Higher anthocyanin intake is associated with lower arterial stiffness and central blood pressure in women. Am J Clin Nutr 96:781–788. https://doi.org/10.3945/ajcn.112.042036
Johnson EJ (2002) The role of carotenoids in human health. Nutr Clin Care 5(2):56–65
Kalra EK (2003) Nutraceutical – Definition and introduction. AAPS Pharm Sci 5:E25
Khalesi S, Sun J, Buys N, Jamshidi A, Nikbakht-Nasrabadi E, Khosravi-Boroujeni H (2014) Green tea catechins and blood pressure: a systematic review and meta-analysis of randomised controlled trials. Eur J Nutr 53(6):1299–1311
Khan MM, Ahmad A, Ishrat T, Khuwaja G, Srivastawa P, Khan MB, Raza SS, Javed H, Vaibhav K, Khan A, Islam F (2009) Rutin protects the neural damage induced by transient focal ischemia in rats. Brain Res 1292:123–135
Kim A, Chiu A, Barone MK, Avino D, Wang F, Coleman CI, Phung OJ (2011) Green tea catechins decrease total and low-density lipoprotein cholesterol: a systematic review and meta-analysis. J Am Diet Assoc 111(11):1720–1729
Kindle L (2001) The top 100 R&D® survey. Food Process 62:18–22
Krutmann J (2008) Protection from sunburn with beta-Carotene – a meta-analysis. Photochem Photobiol 84(2):284–288
Leon F (2003) Functional foods. In: Encyclopedia of food sciences and nutrition, 2nd edn. Academic Press, Amsterdam, pp 2827–2832
Lin BW, Gong CC, Song HF, Cui YY (2017) Effects of anthocyanins on the prevention and treatment of cancer. Br J Pharmacol 174(11):1226–1243. https://doi.org/10.1111/bph.13627
Litwin N, Clifford J, Johnson S. (2018) Functional foods for health. Retrieved from https://extension.colostate.edu/topic-areas/nutrition-food-safety-health/functional-foods-for-health-9-391/
Markets and Markets (2019) Functional food ingredients market by type (probiotics, prebiotics, proteins & amino acids, phytochemical & plant extracts, omega-3 fatty acids, carotenoids, fibers & specialty carbohydrates), application, source, and region – global forecast to 2023. Retrieved from https://www.marketsandmarkets.com/Market-Reports/functional-food-ingredients-market-9242020.html
Martirosyan DM, Singh J (2015) A new definition for functional food by FFC: creating functional food products using new definition. Retrieved from https://www.functionalfoodscenter.net/files/111174880.pdf
McCullough ML, Peterson JJ, Patel R, Jacques PF, Shah R, Dwyer JT (2012) Flavonoid intake and cardiovascular disease mortality in a prospective cohort of US adults. Am J Clin Nutr 95:454–464. https://doi.org/10.3945/ajcn.111.016634
Mink PJ, Scrafford CG, Barraj LM, Harnack L, Hong CP, Nettleton JA, Jacobs DR Jr (2007) Flavonoid intake and cardiovascular disease mortality: A prospective study in postmenopausal women. Am J Clin Nutr 85:895–909
Mir MA (2018) Porphyria overview. Medscape 2018. Retrieved from https://emedicine.medscape.com/article/1389981-overview
Nasri H, Baradaran A, Shirzad H, Rafieian-Kopaei M (2014) New concepts in nutraceuticals as alternative for pharmaceuticals. Int J Prev Med 5(12):1487–1499
Norwegian University of Science and Technology (2019) What is biotechnology? Retrieved from https://www.ntnu.edu/ibt/about-us/what-is-biotechnology
Pavlidis C, Patrinos GP, Katsila T (2015) Nutrigenomics: a controversy. Appl Transl Genomics 4:50–53
Pérez-Cano FJ, Castell M (2016) Flavonoids, inflammation and immune system. Nutrients 8(10):659. https://doi.org/10.3390/nu8100659
Pu F, Mishima K, Irie K, Motohashi K, Tanaka Y, Orito K, Egawa T, Kitamura Y, Egashira N, Iwasaki K, Fujiwara M (2007) Neuroprotective effects of quercetin and rutin on spatial memory impairment in an 8-arm radial maze task and neuronal death induced by repeated cerebral ischemia in rats. J Pharmacol Sci 104:329–334
Qin Y, Xia M, Ma J, Hao YT, Liu J, Mou HY, Cao L, Ling W (2009) Anthocyanin supplementation improves serum LDL- and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects. Am J Clin Nutr 90:485–492. https://doi.org/10.3945/ajcn.2009.27814
Ried K, Fakler P (2011 Apr 1) Protective effect of lycopene on serum cholesterol and blood pressure: Meta-analyses of intervention trials. Maturitas 68(4):299–310
Roberfroid MB (2007) Inulin-type fructans: functional food ingredients. J Nutr 137(11):2493S–2502S
Rollman O, Vahlquist A (1985) Psoriasis and vitamin A. Plasma transport and skin content of retinol, dehydroretinol and carotenoids in adult patients versus healthy controls. Arch Dermatol Res 278(1):17–24
Rowles JL III, Ranard KM, Smith JW, An R, Erdman JW Jr (2017 Dec) Increased dietary and circulating lycopene are associated with reduced prostate cancer risk: a systematic review and meta-analysis. Prostate Cancer Prostatic Dis 20(4):361
Sassa S (2006 Nov) Modern diagnosis and management of the porphyrias. Br J Haematol 135(3):281–292
Senkus KE, Tan L, Crowe-White KM (2018) Lycopene and metabolic syndrome: a systematic review of the literature. Adv Nutr 10(1):19–29
Serafini M, Peluso I, Raguzzini A (2010) Session 1: Antioxidants and the immune system Flavonoids as anti-inflammatory agents. Proc Nutr Soc 69(3):273–278. https://doi.org/10.1017/S002966511000162X
Serban MC, Sahebkar A, Zanchetti A, Mikhailidis DP, Howard G, Antal D, Andrica F, Ahmed A, Aronow WS, Muntner P, Lip GY (2016) Effects of quercetin on blood pressure: a systematic review and meta-analysis of randomized controlled trials. J Am Heart Assoc 5(7):e002713
Shah PM, Priya VV, Gayathri R (2016) Quercetin-a flavonoid: a systematic review. Int J Pharm Sci Res 8(8):878
Sion Tee A, Wong J, Chan P (2018) Functional foods monography 2017, ILSI Southeast Asia region monograph series. International Life Sciences Institute Southeast Asia Region
Stahl W, Sies H (2012) β-Carotene and other carotenoids in protection from sunlight. Am J Clin Nutr 96(5):1179S–1184S. https://doi.org/10.3945/ajcn.112.034819
Thomas PR, Earl R (eds) (1994) Committee on opportunities in the nutrition and food sciences, food and nutrition board, institute of medicine. In: Opportunities in the nutrition and food sciences: research challenges and the next generation of investigators. National Academy Press, Washington, DC, pp 98–142
Trottier G, Bostrom PJ, Lawrentschuk N, Fleshner NE (2010) Nutraceuticals and prostate cancer prevention: a current review. Nat Rev Urol 7:21–30
Ugusman A, Zakaria Z, Chua KH, Nordin NA, Abdullah MZ (2014) Role of rutin on nitric oxide synthesis in human umbilical vein endothelial cells. Sci World J 2014:169370
Villaño D, Vilapana A, Vigeura C, Moreno DA (2016) Chapter 10: Development of functional foods. In: Innovation strategies in the food industry tools for implementation. Elsevier Science & Technology, San Diego, pp 191–210
Wallace TC, Giusti MM (2013) Chapter: 10: Effects of anthocyanins on neuronal and cognitive brain functions. In: Anthocyanins in health and disease. https://doi.org/10.1201/b15554-11
Wallace TC, Slavin M, Frankenfeld CL (2016) Systematic review of anthocyanins and markers of cardiovascular disease. Nutrients 8(1):32. https://doi.org/10.3390/nu8010032
Wang LS, Stoner GD (2008) Anthocyanins and their role in cancer prevention. Cancer Lett 269(2):281–290. https://doi.org/10.1016/j.canlet.2008.05.020
Wang Y, Cui R, Xiao Y, Fang J, Xu Q (2015) Effect of carotene and lycopene on the risk of prostate cancer: a systematic review and dose-response meta-analysis of observational studies. PLoS One 10(9):e0137427
Whyte AR, Williams CM (2012) The cognitive effects of acute blueberry anthocyanin interventions on 7–9 year old children. Appetite 59(2):637
Wolfram T (2017) Functional foods. Academy of Nutrition and Dietetics. Retrieved from https://www.eatright.org/food/nutrition/healthy-eating/functional-foods
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Dable-Tupas, G., Otero, M.C.B., Bernolo, L. (2020). Functional Foods and Health Benefits. In: Egbuna, C., Dable Tupas, G. (eds) Functional Foods and Nutraceuticals. Springer, Cham. https://doi.org/10.1007/978-3-030-42319-3_1
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