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Exercise Oncology pp 87–110Cite as

Exercise Oncology from Diagnosis to Treatment: An Overview of Outcomes and Considerations

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Abstract

Cancer patients and survivors experience wide-ranging acute and persistent toxicities that have implications to reduced physical function, cardiovascular and metabolic complications, musculoskeletal health and quality of life. Over the past several years, the field of exercise oncology has demonstrated a number of opportunities for the use of exercise as a medicine to preserve function and ameliorate and reverse a range of treatment-related adverse effects in patients with cancer receiving treatment. Numerous randomized controlled trials have evolved from early study reports on symptom controls to more contemporary trials investigating clinical and disease-specific endpoints. In this chapter, we provide a brief overview of common cancer treatments and adverse effects and examples of early to contemporary exercise oncology studies including those from pretreatment to during treatment phases examining a range of outcomes and provide considerations and future opportunities in this well-established and yet continuing area of research growth in exercise oncology. As the field continues to evolve in its breath, scope and rigour, future large definitive trials will provide more conclusive information on the role of exercise and its impact on disease progression and cancer-specific and overall survival.

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References

  1. Schmitz KH, Cappola AR, Stricker CT, Sweeney C, Norman SA. The intersection of cancer and aging: establishing the need for breast cancer rehabilitation. Cancer Epidemiol Biomark Prev. 2007;16(5):866–72.

    Article  Google Scholar 

  2. Galvao DA, Taaffe DR, Spry N, Newton RU. Exercise can prevent and even reverse adverse effects of androgen suppression treatment in men with prostate cancer. Prostate Cancer Prostatic Dis. 2007;10(4):340–6.

    Article  CAS  PubMed  Google Scholar 

  3. Hahn VS, Lenihan DJ, Ky B. Cancer therapy-induced cardiotoxicity: basic mechanisms and potential cardioprotective therapies. J Am Heart Assoc. 2014;3(2):e000665.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  4. Walls GM, Lyon AR, Harbinson MT, Hanna GG. Cardiotoxicity following cancer treatment. Ulster Med J. 2017;86(1):3–9.

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Kumar RJ, Barqawi A, Crawford ED. Adverse events associated with hormonal therapy for prostate cancer. Rev Urol. 2005;7(Suppl 5):S37–43.

    PubMed  PubMed Central  Google Scholar 

  6. Storer TW, Miciek R, Travison TG. Muscle function, physical performance and body composition changes in men with prostate cancer undergoing androgen deprivation therapy. Asian J Androl. 2012;14(2):204–21.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Galvao DA, Spry NA, Taaffe DR, Newton RU, Stanley J, Shannon T, et al. Changes in muscle, fat and bone mass after 36 weeks of maximal androgen blockade for prostate cancer. BJU Int. 2008;102(1):44–7.

    Article  PubMed  Google Scholar 

  8. Westerink NL, Nuver J, Lefrandt JD, Vrieling AH, Gietema JA, Walenkamp AM. Cancer treatment induced metabolic syndrome: improving outcome with lifestyle. Crit Rev Oncol Hematol. 2016;108:128–36.

    Article  CAS  PubMed  Google Scholar 

  9. Aleman BM, Moser EC, Nuver J, Suter TM, Maraldo MV, Specht L, et al. Cardiovascular disease after cancer therapy. EJC Suppl. 2014;12(1):18–28.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Gallagher EJ, LeRoith D. Obesity and diabetes: the increased risk of cancer and cancer-related mortality. Physiol Rev. 2015;95(3):727–48.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Cho KM, Park H, Oh DY, Kim TY, Lee KH, Han SW, et al. Skeletal muscle depletion predicts survival of patients with advanced biliary tract cancer undergoing palliative chemotherapy. Oncotarget. 2017;8(45):79441–52.

    PubMed  PubMed Central  Google Scholar 

  12. Rier HN, Jager A, Sleijfer S, Maier AB, Levin MD. The prevalence and prognostic value of low muscle mass in cancer patients: a review of the literature. Oncologist. 2016;21(11):1396–409.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69(1):7–34.

    Article  PubMed  Google Scholar 

  14. MacVicar MG, Winningham ML, Nickel JL. Effects of aerobic interval training on cancer patients' functional capacity. Nurs Res. 1989;38(6):348–51.

    Article  CAS  PubMed  Google Scholar 

  15. Winningham ML, MacVicar MG. The effect of aerobic exercise on patient reports of nausea. Oncol Nurs Forum. 1988;15(4):447–50.

    CAS  PubMed  Google Scholar 

  16. Winningham ML, MacVicar MG, Bondoc M, Anderson JI, Minton JP. Effect of aerobic exercise on body weight and composition in patients with breast cancer on adjuvant chemotherapy. Oncol Nurs Forum. 1989;16(5):683–9.

    CAS  PubMed  Google Scholar 

  17. Dimeo F, Bertz H, Finke J, Fetscher S, Mertelsmann R, Keul J. An aerobic exercise program for patients with haematological malignancies after bone marrow transplantation. Bone Marrow Transplant. 1996;18(6):1157–60.

    CAS  PubMed  Google Scholar 

  18. Dimeo F, Fetscher S, Lange W, Mertelsmann R, Keul J. Effects of aerobic exercise on the physical performance and incidence of treatment-related complications after high-dose chemotherapy. Blood. 1997;90(9):3390–4.

    Article  CAS  PubMed  Google Scholar 

  19. Dimeo FC, Tilmann MH, Bertz H, Kanz L, Mertelsmann R, Keul J. Aerobic exercise in the rehabilitation of cancer patients after high dose chemotherapy and autologous peripheral stem cell transplantation. Cancer. 1997;79(9):1717–22.

    Article  CAS  PubMed  Google Scholar 

  20. Segal R, Evans W, Johnson D, Smith J, Colletta S, Gayton J, et al. Structured exercise improves physical functioning in women with stages I and II breast cancer: results of a randomized controlled trial. J Clin Oncol. 2001;19(3):657–65.

    Article  CAS  PubMed  Google Scholar 

  21. Segal RJ, Reid RD, Courneya KS, Malone SC, Parliament MB, Scott CG, et al. Resistance exercise in men receiving androgen deprivation therapy for prostate cancer. J Clin Oncol. 2003;21(9):1653–9.

    Article  PubMed  Google Scholar 

  22. Courneya KS, Mackey JR, Bell GJ, Jones LW, Field CJ, Fairey AS. Randomized controlled trial of exercise training in postmenopausal breast cancer survivors: cardiopulmonary and quality of life outcomes. J Clin Oncol. 2003;21(9):1660–8.

    Article  PubMed  Google Scholar 

  23. Rayson D, Reyno L. Exercise and cancer: no pain, some gain? J Clin Oncol. 2003;21(9):1651–2.

    Article  PubMed  Google Scholar 

  24. Astolfi L, Ghiselli S, Guaran V, Chicca M, Simoni E, Olivetto E, et al. Correlation of adverse effects of cisplatin administration in patients affected by solid tumours: a retrospective evaluation. Oncol Rep. 2013;29(4):1285–92.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Pearce A, Haas M, Viney R, Pearson SA, Haywood P, Brown C, et al. Incidence and severity of self-reported chemotherapy side effects in routine care: a prospective cohort study. PLoS One. 2017;12(10):e0184360.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  26. Michot A, Stoeckle E, Bannel JD, Colombani S, Sargos P, Brouste V, et al. The introduction of early patient rehabilitation in surgery of soft tissue sarcoma and its impact on post-operative outcome. Eur J Surg Oncol. 2015;41(12):1678–84.

    Article  CAS  PubMed  Google Scholar 

  27. Vodanovich DA, PF MC. Soft-tissue sarcomas. Indian J Orthop. 2018;52(1):35–44.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Merchant SJ, Chen SL. Prevention and management of lymphedema after breast cancer treatment. Breast J. 2015;21(3):276–84.

    Article  PubMed  Google Scholar 

  29. Sardaro A, Petruzzelli MF, D'Errico MP, Grimaldi L, Pili G, Portaluri M. Radiation-induced cardiac damage in early left breast cancer patients: risk factors, biological mechanisms, radiobiology, and dosimetric constraints. Radiother Oncol. 2012;103(2):133–42.

    Article  PubMed  Google Scholar 

  30. Slezak J, Kura B, Ravingerova T, Tribulova N, Okruhlicova L, Barancik M. Mechanisms of cardiac radiation injury and potential preventive approaches. Can J Physiol Pharmacol. 2015;93(9):737–53.

    Article  CAS  PubMed  Google Scholar 

  31. Kamen C, Tejani MA, Chandwani K, Janelsins M, Peoples AR, Roscoe JA, et al. Anticipatory nausea and vomiting due to chemotherapy. Eur J Pharmacol. 2014;722:172–9.

    Article  CAS  PubMed  Google Scholar 

  32. Ranganath P, Einhorn L, Albany C. Management of chemotherapy induced nausea and vomiting in patients on multiday cisplatin based combination chemotherapy. Biomed Res Int. 2015;2015:943618.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  33. Tantoy IY, Cooper BA, Dhruva A, Cataldo J, Paul SM, Conley YP, et al. Changes in the occurrence, severity, and distress of symptoms in patients with gastrointestinal cancers receiving chemotherapy. J Pain Symptom Manag. 2018;55(3):808–34.

    Article  Google Scholar 

  34. Zhang B, Dong JN, Sun P, Feng C, Liu YC. Effect of therapeutic care for treating fatigue in patients with breast cancer receiving chemotherapy. Medicine (Baltimore). 2017;96(33):e7750.

    Article  Google Scholar 

  35. Moore HC. An overview of chemotherapy-related cognitive dysfunction, or ‘chemobrain’. Oncology (Williston Park). 2014;28(9):797–804.

    Google Scholar 

  36. Henning RJ, Harbison RD. Cardio-oncology: cardiovascular complications of cancer therapy. Futur Cardiol. 2017;13(4):379–96.

    Article  CAS  Google Scholar 

  37. Scott JM, Nilsen TS, Gupta D, Jones LW. Exercise therapy and cardiovascular toxicity in cancer. Circulation. 2018;137(11):1176–91.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Winters-Stone KM, Horak F, Jacobs PG, Trubowitz P, Dieckmann NF, Stoyles S, et al. Falls, functioning, and disability among women with persistent symptoms of chemotherapy-induced peripheral neuropathy. J Clin Oncol. 2017;35(23):2604–12.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Demark-Wahnefried W, Peterson BL, Winer EP, Marks L, Aziz N, Marcom PK, et al. Changes in weight, body composition, and factors influencing energy balance among premenopausal breast cancer patients receiving adjuvant chemotherapy. J Clin Oncol. 2001;19(9):2381–9.

    Article  CAS  PubMed  Google Scholar 

  40. van den Berg MM, Winkels RM, de Kruif JT, van Laarhoven HW, Visser M, de Vries JH, et al. Weight change during chemotherapy in breast cancer patients: a meta-analysis. BMC Cancer. 2017;17(1):259.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Kate A, Kadambari D. Incidence of metabolic syndrome in breast cancer survivors on adjuvant hormonal therapy. J Pharmacol Pharmacother. 2016;7(1):28–30.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Redig AJ, Munshi HG. Care of the cancer survivor: metabolic syndrome after hormone-modifying therapy. Am J Med. 2010;123(1):87.e1–6.

    Article  PubMed Central  Google Scholar 

  43. Tzortzis V, Samarinas M, Zachos I, Oeconomou A, Pisters LL, Bargiota A. Adverse effects of androgen deprivation therapy in patients with prostate cancer: focus on metabolic complications. Hormones (Athens). 2017;16(2):115–23.

    Google Scholar 

  44. Lacouture M, Sibaud V. Toxic side effects of targeted therapies and immunotherapies affecting the skin, oral mucosa, hair, and nails. Am J Clin Dermatol. 2018;19(Suppl 1):31–9.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Brahmer JR, Lacchetti C, Schneider BJ, Atkins MB, Brassil KJ, Caterino JM, et al. Management of immune-related adverse events in patients treated with immune checkpoint inhibitor therapy: American Society of Clinical Oncology clinical practice guideline. J Clin Oncol. 2018;36(17):1714–68.

    Article  CAS  PubMed  Google Scholar 

  46. Naidoo J, Page DB, Li BT, Connell LC, Schindler K, Lacouture ME, et al. Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies. Ann Oncol. 2015;26(12):2375–91.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Cunningham BA, Morris G, Cheney CL, Buergel N, Aker SN, Lenssen P. Effects of resistive exercise on skeletal muscle in marrow transplant recipients receiving total parenteral nutrition. JPEN J Parenter Enteral Nutr. 1986;10(6):558–63.

    Article  CAS  PubMed  Google Scholar 

  48. Courneya KS, Friedenreich CM. Framework PEACE: an organizational model for examining physical exercise across the cancer experience. Ann Behav Med. 2001;23(4):263–72.

    Article  CAS  PubMed  Google Scholar 

  49. Courneya KS, Friedenreich CM. Physical activity and cancer control. Semin Oncol Nurs. 2007;23(4):242–52.

    Article  PubMed  Google Scholar 

  50. Demark-Wahnefried W, Aziz NM, Rowland JH, Pinto BM. Riding the crest of the teachable moment: promoting long-term health after the diagnosis of cancer. J Clin Oncol. 2005;23(24):5814–30.

    Article  PubMed  Google Scholar 

  51. Lee AS, Ozakinci G, Leung S, Humphris G, Dale H, Hamlet N. Lifestyle change in the cancer setting using ‘the teachable moment’: protocol for a proof-of-concept pilot in a urology service. Pilot Feasibility Stud. 2016;2:65.

    Article  PubMed  PubMed Central  Google Scholar 

  52. Galvao DA, Taaffe DR, Spry N, Gardiner RA, Taylor R, Risbridger GP, et al. Enhancing active surveillance of prostate cancer: the potential of exercise medicine. Nat Rev Urol. 2016;13(5):258–65.

    Article  PubMed  Google Scholar 

  53. Cooperberg MR, Carroll PR, Klotz L. Active surveillance for prostate cancer: progress and promise. J Clin Oncol. 2011;29(27):3669–76.

    Article  PubMed  Google Scholar 

  54. Ornish D, Weidner G, Fair WR, Marlin R, Pettengill EB, Raisin CJ, et al. Intensive lifestyle changes may affect the progression of prostate cancer. J Urol. 2005;174(3):1065–9.

    Article  PubMed  Google Scholar 

  55. Frattaroli J, Weidner G, Dnistrian AM, Kemp C, Daubenmier JJ, Marlin RO, et al. Clinical events in prostate cancer lifestyle trial: results from two years of follow-up. Urology. 2008;72(6):1319–23.

    Article  PubMed  Google Scholar 

  56. Bourke L, Stevenson R, Turner R, Hooper R, Sasieni P, Greasley R, et al. Exercise training as a novel primary treatment for localised prostate cancer: a multi-site randomised controlled phase II study. Sci Rep. 2018;8:8374.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. Galvao DA, Hayne D, Frydenberg M, Chambers SK, Taaffe DR, Spry N, et al. Can exercise delay transition to active therapy in men with low-grade prostate cancer? A multicentre randomised controlled trial. BMJ Open. 2018;8(4):e022331.

    Article  PubMed  PubMed Central  Google Scholar 

  58. Courneya KS, Friedenreich CM. Relationship between exercise pattern across the cancer experience and current quality of life in colorectal cancer survivors. J Altern Complement Med. 1997;3(3):215–26.

    Article  CAS  PubMed  Google Scholar 

  59. Irwin ML, Crumley D, McTiernan A, Bernstein L, Baumgartner R, Gilliland FD, et al. Physical activity levels before and after a diagnosis of breast carcinoma: the Health, Eating, Activity, and Lifestyle (HEAL) study. Cancer. 2003;97(7):1746–57.

    Article  PubMed  Google Scholar 

  60. Jones LW, Peddle CJ, Eves ND, Haykowsky MJ, Courneya KS, Mackey JR, et al. Effects of presurgical exercise training on cardiorespiratory fitness among patients undergoing thoracic surgery for malignant lung lesions. Cancer. 2007;110(3):590–8.

    Article  PubMed  Google Scholar 

  61. Licker M, Karenovics W, Diaper J, Fresard I, Triponez F, Ellenberger C, et al. Short-term preoperative high-intensity interval training in patients awaiting lung cancer surgery: a randomized controlled trial. J Thorac Oncol. 2017;12(2):323–33.

    Article  PubMed  Google Scholar 

  62. Singh F, Newton RU, Galvao DA, Spry N, Baker MK. A systematic review of pre-surgical exercise intervention studies with cancer patients. Surg Oncol. 2013;22(2):92–104.

    Article  PubMed  Google Scholar 

  63. Santa Mina D, Hilton WJ, Matthew AG, Awasthi R, Bousquet-Dion G, Alibhai SMH, et al. Prehabilitation for radical prostatectomy: a multicentre randomized controlled trial. Surg Oncol. 2018;27(2):289–98.

    Article  PubMed  Google Scholar 

  64. Lee J. Effects of exercise interventions on breast cancer patients during adjuvant therapy: a systematic review and meta-analysis of randomized controlled trials. Cancer Nurs. 2020;43(2):115–25.

    Google Scholar 

  65. Lipsett A, Barrett S, Haruna F, Mustian K, O’Donovan A. The impact of exercise during adjuvant radiotherapy for breast cancer on fatigue and quality of life: a systematic review and meta-analysis. Breast. 2017;32:144–55.

    Article  PubMed  Google Scholar 

  66. van Rooijen SJ, Engelen MA, Scheede-Bergdahl C, Carli F, Roumen RMH, Slooter GD, et al. Systematic review of exercise training in colorectal cancer patients during treatment. Scand J Med Sci Sports. 2018;28(2):360–70.

    Article  PubMed  Google Scholar 

  67. van Vulpen JK, Peeters PH, Velthuis MJ, van der Wall E, May AM. Effects of physical exercise during adjuvant breast cancer treatment on physical and psychosocial dimensions of cancer-related fatigue: a meta-analysis. Maturitas. 2016;85:104–11.

    Article  PubMed  Google Scholar 

  68. Aversa A, Francomano D, Lenzi A. Cardiometabolic complications after androgen deprivation therapy in a man with prostate cancer: effects of 3 years intermittent testosterone supplementation. Front Endocrinol (Lausanne). 2012;3:17.

    Article  CAS  Google Scholar 

  69. Chang HM, Moudgil R, Scarabelli T, Okwuosa TM, Yeh ETH. Cardiovascular complications of cancer therapy: best practices in diagnosis, prevention, and management: Part 1. J Am Coll Cardiol. 2017;70(20):2536–51.

    Article  PubMed  PubMed Central  Google Scholar 

  70. Segal RJ, Reid RD, Courneya KS, Sigal RJ, Kenny GP, Prud'Homme DG, et al. Randomized controlled trial of resistance or aerobic exercise in men receiving radiation therapy for prostate cancer. J Clin Oncol. 2009;27(3):344–51.

    Article  PubMed  Google Scholar 

  71. Courneya KS, Sellar CM, Stevinson C, McNeely ML, Peddle CJ, Friedenreich CM, et al. Randomized controlled trial of the effects of aerobic exercise on physical functioning and quality of life in lymphoma patients. J Clin Oncol. 2009;27(27):4605–12.

    Article  PubMed  Google Scholar 

  72. Scott JM, Zabor EC, Schwitzer E, Koelwyn GJ, Adams SC, Nilsen TS, et al. Efficacy of exercise therapy on cardiorespiratory fitness in patients with cancer: a systematic review and meta-analysis. J Clin Oncol. 2018;36(22):2297–305.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  73. Christensen JF, Simonsen C, Hojman P. Exercise training in cancer control and treatment. Compr Physiol. 2018;9(1):165–205.

    Article  PubMed  Google Scholar 

  74. Galvao DA, Taaffe DR, Spry N, Joseph D, Newton RU. Combined resistance and aerobic exercise program reverses muscle loss in men undergoing androgen suppression therapy for prostate cancer without bone metastases: a randomized controlled trial. J Clin Oncol. 2010;28(2):340–7.

    Article  CAS  PubMed  Google Scholar 

  75. Smith MR, Finkelstein JS, McGovern FJ, Zietman AL, Fallon MA, Schoenfeld DA, et al. Changes in body composition during androgen deprivation therapy for prostate cancer. J Clin Endocrinol Metab. 2002;87(2):599–603.

    Article  CAS  PubMed  Google Scholar 

  76. Demark-Wahnefried W, Case LD, Blackwell K, Marcom PK, Kraus W, Aziz N, et al. Results of a diet/exercise feasibility trial to prevent adverse body composition change in breast cancer patients on adjuvant chemotherapy. Clin Breast Cancer. 2008;8(1):70–9.

    Article  PubMed  Google Scholar 

  77. Mustian KM, Peppone L, Darling TV, Palesh O, Heckler CE, Morrow GR. A 4-week home-based aerobic and resistance exercise program during radiation therapy: a pilot randomized clinical trial. J Support Oncol. 2009;7(5):158–67.

    PubMed  PubMed Central  Google Scholar 

  78. Stene GB, Helbostad JL, Balstad TR, Riphagen II, Kaasa S, Oldervoll LM. Effect of physical exercise on muscle mass and strength in cancer patients during treatment--a systematic review. Crit Rev Oncol Hematol. 2013;88(3):573–93.

    Article  CAS  PubMed  Google Scholar 

  79. Campos MP, Hassan BJ, Riechelmann R, Del Giglio A. Cancer-related fatigue: a practical review. Ann Oncol. 2011;22(6):1273–9.

    Article  CAS  PubMed  Google Scholar 

  80. Puetz TW, Herring MP. Differential effects of exercise on cancer-related fatigue during and following treatment: a meta-analysis. Am J Prev Med. 2012;43(2):e1–24.

    Article  PubMed  Google Scholar 

  81. Hilfiker R, Meichtry A, Eicher M, Nilsson Balfe L, Knols RH, Verra ML, et al. Exercise and other non-pharmaceutical interventions for cancer-related fatigue in patients during or after cancer treatment: a systematic review incorporating an indirect-comparisons meta-analysis. Br J Sports Med. 2018;52(10):651–8.

    Article  PubMed  Google Scholar 

  82. Taaffe DR, Newton RU, Spry N, Joseph D, Chambers SK, Gardiner RA, et al. Effects of different exercise modalities on fatigue in prostate cancer patients undergoing androgen deprivation therapy: a year-long randomised controlled trial. Eur Urol. 2017;72(2):293–9.

    Article  PubMed  Google Scholar 

  83. Kessels E, Husson O, van der Feltz-Cornelis CM. The effect of exercise on cancer-related fatigue in cancer survivors: a systematic review and meta-analysis. Neuropsychiatr Dis Treat. 2018;14:479–94.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  84. Drake MT. Osteoporosis and cancer. Curr Osteoporos Rep. 2013;11(3):163–70.

    Article  PubMed  PubMed Central  Google Scholar 

  85. Newton RU, Galvao DA, Spry N, Joseph D, Chambers SK, Gardiner RA, et al. Exercise mode specificity for preserving spine and hip BMD in prostate cancer patients. Med Sci Sports Exerc. 2018;51(4):607–14.

    Article  CAS  Google Scholar 

  86. Cramer JA, Gold DT, Silverman SL, Lewiecki EM. A systematic review of persistence and compliance with bisphosphonates for osteoporosis. Osteoporos Int. 2007;18(8):1023–31.

    Article  CAS  PubMed  Google Scholar 

  87. Mishra SI, Scherer RW, Snyder C, Geigle PM, Berlanstein DR, Topaloglu O. Exercise interventions on health-related quality of life for people with cancer during active treatment. Clin Otolaryngol. 2012;37(5):390–2.

    Article  PubMed  Google Scholar 

  88. Duijts SF, Faber MM, Oldenburg HS, van Beurden M, Aaronson NK. Effectiveness of behavioral techniques and physical exercise on psychosocial functioning and health-related quality of life in breast cancer patients and survivors–a meta-analysis. Psychooncology. 2011;20(2):115–26.

    Article  PubMed  Google Scholar 

  89. Brown JC, Huedo-Medina TB, Pescatello LS, Ryan SM, Pescatello SM, Moker E, et al. The efficacy of exercise in reducing depressive symptoms among cancer survivors: a meta-analysis. PLoS One. 2012;7(1):e30955.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  90. Taaffe DR, Galvao DA, Spry N, Joseph D, Chambers SK, Gardiner RA, et al. Immediate versus delayed exercise in men initiating androgen deprivation: effects on bone density and soft tissue composition. BJU Int. 2019;123(2):261–9.

    Article  CAS  PubMed  Google Scholar 

  91. Capozzi LC, McNeely ML, Lau HY, Reimer RA, Giese-Davis J, Fung TS, et al. Patient-reported outcomes, body composition, and nutrition status in patients with head and neck cancer: results from an exploratory randomized controlled exercise trial. Cancer. 2016;122(8):1185–200.

    Article  PubMed  Google Scholar 

  92. Courneya KS, Segal RJ, Mackey JR, Gelmon K, Reid RD, Friedenreich CM, et al. Effects of aerobic and resistance exercise in breast cancer patients receiving adjuvant chemotherapy: a multicenter randomized controlled trial. J Clin Oncol. 2007;25(28):4396–404.

    Article  PubMed  Google Scholar 

  93. van Waart H, Stuiver MM, van Harten WH, Geleijn E, Kieffer JM, Buffart LM, et al. Effect of low-intensity physical activity and moderate- to high-intensity physical exercise during adjuvant chemotherapy on physical fitness, fatigue, and chemotherapy completion rates: results of the PACES randomized clinical trial. J Clin Oncol. 2015;33(17):1918–27.

    Article  PubMed  CAS  Google Scholar 

  94. Bland KA. Impact of exercise on chemotherapy completion rate: a systematic review of the evidence and recommendations for future exercise oncology research. Crit Rev Oncol Hematol. 2019;136:79–85.

    Article  PubMed  Google Scholar 

  95. Oldervoll LM, Loge JH, Lydersen S, Paltiel H, Asp MB, Nygaard UV, et al. Physical exercise for cancer patients with advanced disease: a randomized controlled trial. Oncologist. 2011;16(11):1649–57.

    Article  PubMed  PubMed Central  Google Scholar 

  96. Jensen W, Bialy L, Ketels G, Baumann FT, Bokemeyer C, Oechsle K. Physical exercise and therapy in terminally ill cancer patients: a retrospective feasibility analysis. Support Care Cancer. 2014;22(5):1261–8.

    Article  PubMed  Google Scholar 

  97. Galvao DA, Taaffe DR, Spry N, Cormie P, Joseph D, Chambers SK, et al. Exercise preserves physical function in prostate Cancer patients with bone metastases. Med Sci Sport Exer. 2018;50(3):393–9.

    Article  Google Scholar 

  98. Small EJ, Smith MR, Seaman JJ, Petrone S, Kowalski MO. Combined analysis of two multicenter, randomized, placebo-controlled studies of pamidronate disodium for the palliation of bone pain in men with metastatic prostate cancer. J Clin Oncol. 2003;21(23):4277–84.

    Article  CAS  PubMed  Google Scholar 

  99. Fizazi K, Beuzeboc P, Lumbroso J, Haddad V, Massard C, Gross-Goupil M, et al. Phase II trial of consolidation docetaxel and samarium-153 in patients with bone metastases from castration-resistant prostate cancer. J Clin Oncol. 2009;27(15):2429–35.

    Article  CAS  PubMed  Google Scholar 

  100. Carlin BI, Andriole GL. The natural history, skeletal complications, and management of bone metastases in patients with prostate carcinoma. Cancer. 2000;88(12 Suppl):2989–94.

    Article  CAS  PubMed  Google Scholar 

  101. Saad F, Olsson C, Schulman CC. Skeletal morbidity in men with prostate cancer: quality-of-life considerations throughout the continuum of care. Eur Urol. 2004;46(6):731–9; discussion 9–40.

    Google Scholar 

  102. Ballard-Barbash R, Friedenreich CM, Courneya KS, Siddiqi SM, McTiernan A, Alfano CM. Physical activity, biomarkers, and disease outcomes in cancer survivors: a systematic review. J Natl Cancer I. 2012;104(11):815–40.

    Article  Google Scholar 

  103. Schmid D, Leitzmann MF. Association between physical activity and mortality among breast cancer and colorectal cancer survivors: a systematic review and meta-analysis. Ann Oncol. 2014;25(7):1293–311.

    Article  CAS  PubMed  Google Scholar 

  104. Courneya KS, Booth CM, Gill S, O'Brien P, Vardy J, Friedenreich CM, et al. The colon health and life-long exercise change trial: a randomized trial of the National Cancer Institute of Canada Clinical Trials Group. Curr Oncol. 2008;15(6):279–85.

    Article  CAS  PubMed  Google Scholar 

  105. Courneya KS, Vardy JL, O'Callaghan CJ, Friedenreich CM, Campbell KL, Prapavessis H, et al. Effects of a structured exercise program on physical activity and fitness in colon cancer survivors: one year feasibility results from the CHALLENGE trial. Cancer Epidemiol Biomark Prev. 2016;25(6):969–77.

    Article  Google Scholar 

  106. Wiskemann J, Kuehl R, Dreger P, Huber G, Kleindienst N, Ulrich CM, et al. Physical exercise training versus relaxation in allogeneic stem cell transplantation (PETRA study) – rationale and design of a randomized trial to evaluate a yearlong exercise intervention on overall survival and side-effects after allogeneic stem cell transplantation. BMC Cancer. 2015;15:619.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  107. Newton RU, Kenfield SA, Hart NH, Chan JM, Courneya KS, Catto J, et al. Intense Exercise for Survival among Men with Metastatic Castrate-Resistant Prostate Cancer (INTERVAL-GAP4): a multicentre, randomised, controlled phase III study protocol. BMJ Open. 2018;8(5):e022899.

    Article  PubMed  PubMed Central  Google Scholar 

  108. Hayes S, Friedlander M, Obermair A, Mileshkin L, Janda M, Gordon L, Barnes E, Beesley V, Eakin E, Someijer D, Martyn J, Stockler M, Gebski VAL, Naumann F, Schmitz K, Webb P. Exercise during chemotherapy for ovarian cancer (ECHO): study design and outcomes of a Cancer Australia and Cancer Council Australia-funded randomised, controlled trial. Int J Gynecol Cancer. 2014;24(9):200–1.

    Google Scholar 

  109. Ashcraft KA, Warner AB, Jones LW, Dewhirst MW. Exercise as adjunct therapy in cancer. Semin Radiat Oncol. 2019;29(1):16–24.

    Article  PubMed  PubMed Central  Google Scholar 

  110. Hojman P, Gehl J, Christensen JF, Pedersen BK. Molecular mechanisms linking exercise to cancer prevention and treatment. Cell Metab. 2018;27(1):10–21.

    Article  CAS  PubMed  Google Scholar 

  111. Wiggins JM, Opoku-Acheampong AB, Baumfalk DR, Siemann DW, Behnke BJ. Exercise and the tumor microenvironment: potential therapeutic implications. Exerc Sport Sci Rev. 2018;46(1):56–64.

    Article  PubMed  Google Scholar 

  112. Schmitz KH, et al. American College of Sports Medicine roundtable on exercise guidelines for cancer survivors. Med Sci Sports Exerc. 2010;42(7):1409–26.

    Article  PubMed  Google Scholar 

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Acknowledgements

CMF is supported by the National Health and Medical Research Council Centre for Research Excellence in Prostate Cancer Survivorship Postdoctoral Fellowship. DAG is supported by the National Health and Medical Research Council Centre for Research Excellence in Prostate Cancer Survivorship.

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The authors declare there are no conflicts of interest.

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Authors and Affiliations

  1. Edith Cowan University, Exercise Medicine Research Institute, Joondalup, WA, Australia

    Ciaran M. Fairman & Daniel A. Galvão

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  1. Ciaran M. Fairman
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  2. Daniel A. Galvão
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Correspondence to Daniel A. Galvão .

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  1. Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA

    Kathryn H. Schmitz

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Fairman, C.M., Galvão, D.A. (2020). Exercise Oncology from Diagnosis to Treatment: An Overview of Outcomes and Considerations. In: Schmitz, K. (eds) Exercise Oncology. Springer, Cham. https://doi.org/10.1007/978-3-030-42011-6_5

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  • DOI: https://doi.org/10.1007/978-3-030-42011-6_5

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