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Prompt and Convenient Preparation of Oral Vaccines Using Yeast Cell Surface Display

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Fungal Biotechnology and Bioengineering

Part of the book series: Fungal Biology ((FUNGBIO))

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Abstract

The budding yeast, Saccharomyces cerevisiae, has been widely used in fermentation technology. In recent, yeast cell surface has been investigated as potential spaces for immobilizing molecules of interest. The technology of yeast cells to display foreign proteins or peptides by genetic manipulation has been called “cell surface engineering (arming technology)” or “molecular display technology.” Here, the yeast molecular display system is described as convenient method to produce an oral vaccine against various infectious diseases. An antigen derived from Candida albicans was successfully displayed, and it was evaluated on an effect in oral vaccination. Additionally, to expand a possibility of the yeast molecular display technology, screening approach on antigens using proteomic analyses is introduced. Useful combination of proteomic analysis and molecular display technology is discussed with practical application.

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Authors and Affiliations

  1. General Education Center and Graduate School of Pharmacy, Hyogo University of Health Sciences, Kobe, Japan

    Seiji Shibasaki & Miki Karasaki

  2. Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto, Japan

    Wataru Aoki & Mitsuyoshi Ueda

Authors
  1. Seiji Shibasaki
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  2. Miki Karasaki
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  3. Wataru Aoki
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  4. Mitsuyoshi Ueda
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Corresponding author

Correspondence to Seiji Shibasaki .

Editor information

Editors and Affiliations

  1. Department of Genetics Faculty of Agriculture, Beni-Suef University, Beni-Suef, Egypt

    Abd El-Latif Hesham

  2. Department of Botany, Banaras Hindu University, Varanasi, Uttar Pradesh, India

    Ram Sanmukh Upadhyay

  3. Atal Bihari Vajpayee Vishwavidyalaya, Bilaspur, Chhattisgarh, India

    Gauri Dutt Sharma

  4. Department of Botany, Osmania University, Hyderabad, Telangana, India

    Chakravarthula Manoharachary

  5. AgroBioSciences and Chemical & Biochemical Sciences Department, University Mohammed VI Polytechnic (UM6P), Benguerir, Morocco

    Vijai Kumar Gupta

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Shibasaki, S., Karasaki, M., Aoki, W., Ueda, M. (2020). Prompt and Convenient Preparation of Oral Vaccines Using Yeast Cell Surface Display. In: Hesham, AL., Upadhyay, R., Sharma, G., Manoharachary, C., Gupta, V. (eds) Fungal Biotechnology and Bioengineering. Fungal Biology. Springer, Cham. https://doi.org/10.1007/978-3-030-41870-0_4

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