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Carotid Body Tumors: Pre-operative Management and a Review of the Literature

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Abstract

Carotid body tumors are the most common paraganglioma of the neck. Optimal management is multidisciplinary with various considerations of its biochemical effects, vascular supply, and surgical anatomy. This chapter describes the presentation, work up, and treatment with preoperative embolization and radiosurgery. Special attention is given to the literature on evolving techniques used to minimize the operative morbidity associated with cranial nerve deficit and carotid artery compromise The operative techniques for paragangliomas is addressed in the subsequent chapter.

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References

  1. Boedeker CC. Paragangliomas and paraganglioma syndromes. GMS Curr Top Otorhinolaryngol Head Neck Surg. 2011;10:Doc03. https://doi.org/10.3205/cto000076.

    Article  PubMed  Google Scholar 

  2. Shamblin WR, ReMine WH, Sheps SG, Harrison EGJ. Carotid body tumor (chemodectoma). Clinicopathologic analysis of ninety cases. Am J Surg. 1971;122(6):732–9. https://doi.org/10.1016/0002-9610(71)90436-3.

    Article  CAS  PubMed  Google Scholar 

  3. Young WF. Paragangliomas: epidemiology, clinical presentation, diagnosis, and histology. UpToDate.

    Google Scholar 

  4. Lee JA, Duh Q-Y. Sporadic paraganglioma. World J Surg. 2008;32(5):683–7. https://doi.org/10.1007/s00268-007-9360-4.

    Article  PubMed  Google Scholar 

  5. Plouin P-F, Gimenez-Roqueplo A-P. Pheochromocytomas and secreting paragangliomas. Orphanet J Rare Dis. 2006;1:49. https://doi.org/10.1186/1750-1172-1-49.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Torrealba JI, Valdes F, Kramer AH, Mertens R, Bergoeing M, Marine L. Management of carotid bifurcation tumors: 30-year experience. Ann Vasc Surg. 2016;34:200–5. https://doi.org/10.1016/j.avsg.2015.12.029.

    Article  PubMed  Google Scholar 

  7. Neumann HPH, Pawlu C, Peczkowska M, et al. Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations. JAMA. 2004;292(8):943–51. https://doi.org/10.1001/jama.292.8.943.

    Article  CAS  PubMed  Google Scholar 

  8. Amar L, Bertherat J, Baudin E, et al. Genetic testing in pheochromocytoma or functional paraganglioma. J Clin Oncol. 2005;23(34):8812–8. https://doi.org/10.1200/JCO.2005.03.1484.

    Article  CAS  PubMed  Google Scholar 

  9. Taha AY. Carotid body tumors: a review. Int J Clin Med. 2015;6(3):1–13. https://doi.org/10.4236/ijcm.2015.63017.

    Article  Google Scholar 

  10. Pacak K, Tella SH. Pheochromocytoma and Paraganglioma. Endotext.

    Google Scholar 

  11. Papaspyrou K, Mann WJ, Amedee RG. Management of head and neck paragangliomas: review of 120 patients. Head Neck. 2009;31(3):381–7. https://doi.org/10.1002/hed.20967.

    Article  PubMed  Google Scholar 

  12. Chengazi HU, Bhatt AA. Pathology of the carotid space. Insights Imaging. 2019;10(1):21. https://doi.org/10.1186/s13244-019-0704-z.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Colin V, Gavid M, Timochenko A, Prades JM. The parapharyngeal adipose corpus: surgical anatomy and imaging. Morphologie. 2017;101(333):71–6. https://doi.org/10.1016/j.morpho.2017.03.004.

    Article  CAS  PubMed  Google Scholar 

  14. Michalinos A, Chatzimarkos M, Arkadopoulos N, Safioleas M, Troupis T. Anatomical considerations on surgical anatomy of the carotid bifurcation. Anat Res Int. 2016;2016:6907472. https://doi.org/10.1155/2016/6907472.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Van den Berg R, Rodesch G, Lasjaunias P. Management of paragangliomas. Clinical and angiographic aspects. Interv Neuroradiol. 2002;8(2):127–34. https://doi.org/10.1177/159101990200800204.

    Article  PubMed  Google Scholar 

  16. Woolen S, Gemmete JJ. Paragangliomas of the head and neck. Neuroimaging Clin N Am. 2016;26(2):259–78. https://doi.org/10.1016/j.nic.2015.12.005.

    Article  PubMed  Google Scholar 

  17. Sen I, Stephen E, Malepathi K, Agarwal S, Shyamkumar NK, Mammen S. Neurological complications in carotid body tumors: a 6-year single-center experience. J Vasc Surg. 2013;57(2 Suppl):64S–8S. https://doi.org/10.1016/j.jvs.2012.06.114.

    Article  PubMed  Google Scholar 

  18. Davidovic LB, Djukic VB, Vasic DM, Sindjelic RP, Duvnjak SN. Diagnosis and treatment of carotid body paraganglioma: 21 years of experience at a clinical center of Serbia. World J Surg Oncol. 2005;3(1):10. https://doi.org/10.1186/1477-7819-3-10.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Shirakura S, Tsunoda A, Akita K, et al. Parapharyngeal space tumors: anatomical and image analysis findings. Auris Nasus Larynx. 2010;37(5):621–5. https://doi.org/10.1016/j.anl.2010.01.003.

    Article  PubMed  Google Scholar 

  20. Malec K, Cenda P, Brzewski P, Kuchta K, Dobosz P, Modrzejewski M. Paragangliomas of head and neck – a surgical challenge. J Craniomaxillofac Surg. 2017;45(1):127–30. https://doi.org/10.1016/j.jcms.2016.10.003.

    Article  PubMed  Google Scholar 

  21. Basel H, Bozan N. Cervical paragangliomas: experience of 114 cases in 14 years. Braz J Otorhinolaryngol. June 2018; https://doi.org/10.1016/j.bjorl.2018.05.001.

  22. Luna-Ortiz K, Rascon-Ortiz M, Villavicencio-Valencia V, Herrera-Gomez A. Does Shamblin’s classification predict postoperative morbidity in carotid body tumors? A proposal to modify Shamblin’s classification. Eur Arch Otorhinolaryngol. 2006;263(2):171–5. https://doi.org/10.1007/s00405-005-0968-4.

    Article  PubMed  Google Scholar 

  23. Law Y, Chan YC, Cheng SW. Surgical management of carotid body tumor – is Shamblin classification sufficient to predict surgical outcome? Vascular. 2017;25(2):184–9. https://doi.org/10.1177/1708538116657504.

    Article  CAS  PubMed  Google Scholar 

  24. Prasad SC, Laus M, Al-Ghamdi S, Vashishth A, Piazza P, Sanna M. Update in the classification and the role of intra-arterial stenting in the management of carotid body paragangliomas. Head Neck. 2019;41(5):1379–86. https://doi.org/10.1002/hed.25567.

    Article  PubMed  Google Scholar 

  25. Bobadilla-Rosado LO, Garcia-Alva R, Anaya-Ayala JE, et al. Surgical management of bilateral carotid body tumors. Ann Vasc Surg. 2019;57:187–93. https://doi.org/10.1016/j.avsg.2018.10.019.

    Article  PubMed  Google Scholar 

  26. Arya S, Rao V, Juvekar S, Dcruz AK. Carotid body tumors: objective criteria to predict the Shamblin group on MR imaging. AJNR Am J Neuroradiol. 2008;29(7):1349–54. https://doi.org/10.3174/ajnr.A1092.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Gad A, Sayed A, Elwan H, et al. Carotid body tumors: a review of 25 years experience in diagnosis and management of 56 tumors. Ann Vasc Dis. 2014;7(3):292–9. https://doi.org/10.3400/avd.oa.13-00116.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Ma D, Liu M, Yang H, Ma X, Zhang C. Diagnosis and surgical treatment of carotid body tumor: a report of 18 cases. J Cardiovasc Dis Res. 2010;1(3):122–4. https://doi.org/10.4103/0975-3583.70905.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Li J, Wang S, Zee C, et al. Preoperative angiography and transarterial embolization in the management of carotid body tumor: a single-center, 10-year experience. Neurosurgery. 2010;67(4):941–8.; discussion 948. https://doi.org/10.1227/NEU.0b013e3181eda61d.

    Article  PubMed  Google Scholar 

  30. Liu J, Li Y, Yang L, Cai H. Surgical resection of carotid body tumors with versus without preoperative embolization: retrospective case-control study. Head Neck. 2018;40(12):2590–5. https://doi.org/10.1002/hed.25387.

    Article  PubMed  Google Scholar 

  31. Maxwell JG, Jones SW, Wilson E, et al. Carotid body tumor excisions: adverse outcomes of adding carotid endarterectomy. J Am Coll Surg. 2004;198(1):36–41. https://doi.org/10.1016/j.jamcollsurg.2003.08.024.

    Article  PubMed  Google Scholar 

  32. Westerband A, Hunter GC, Cintora I, et al. Current trends in the detection and management of carotid body tumors. J Vasc Surg. 1998;28(1):83–4.

    Article  Google Scholar 

  33. Netterville JL, Reilly KM, Robertson D, Reiber ME, Armstrong WB, Childs P. Carotid body tumors: a review of 30 patients with 46 tumors. Laryngoscope. 1995;105(2):115–26. https://doi.org/10.1288/00005537-199502000-00002.

    Article  CAS  PubMed  Google Scholar 

  34. Economopoulos KP, Tzani A, Reifsnyder T. Adjunct endovascular interventions in carotid body tumors. J Vasc Surg. 2015;61(4):1081–91.e2. https://doi.org/10.1016/j.jvs.2015.01.035.

    Article  PubMed  Google Scholar 

  35. Borges LF, Heros RC, DeBrun G. Carotid body tumors managed with preoperative embolization. Report of two cases. J Neurosurg. 1983;59(5):867–70. https://doi.org/10.3171/jns.1983.59.5.0867.

    Article  CAS  PubMed  Google Scholar 

  36. Dare AO, Gibbons KJ, Gillihan MD, Guterman LR, Loree TR, Hicks WLJ. Hypotensive endovascular test occlusion of the carotid artery in head and neck cancer. Neurosurg Focus. 2003;14(3):e5.

    Article  PubMed  Google Scholar 

  37. Origitano TC, al-Mefty O, Leonetti JP, DeMonte F, Reichman OH. Vascular considerations and complications in cranial base surgery. Neurosurgery. 1994;35(3):351–3. https://doi.org/10.1227/00006123-199409000-00001.

    Article  CAS  PubMed  Google Scholar 

  38. McIvor NP, Willinsky RA, TerBrugge KG, Rutka JA, Freeman JL. Validity of test occlusion studies prior to internal carotid artery sacrifice. Head Neck. 1994;16(1):11–6.

    Article  CAS  PubMed  Google Scholar 

  39. Global Neuroendovascular Coils Market 2017–2021.

    Google Scholar 

  40. Avgerinos ED, Moulakakis K, Brountzos E, et al. Advances in assessment and management of carotid body tumors. Vascular. 2011;19(5):250–6. https://doi.org/10.1258/vasc.2011.oa0291.

    Article  PubMed  Google Scholar 

  41. Alaraj A, Pytynia K, Carlson AP, et al. Combined preoperative onyx embolization and protective internal carotid artery covered stent placement for treatment of glomus vagale tumor: review of literature and illustrative case. Neurol Res. 2012;34(6):523–9. https://doi.org/10.1179/1743132812Y.0000000036.

    Article  PubMed  Google Scholar 

  42. Hennessy O, Jamieson CW, Allison DJ. Pre-operative embolisation of a chemodectoma. Br J Radiol. 1984;57(682):845–6. https://doi.org/10.1259/0007-1285-57-681-845.

    Article  CAS  PubMed  Google Scholar 

  43. Yang T-H, Ou C-H, Yang M-S, Lee Y-C, Yeh L-R. Preoperative embolization of carotid body tumor by direct percutaneous intratumoral injection of N-butyl cyanoacrylate glue assisted with balloon protection technique. J Chin Med Assoc. 2011;74(2):91–4. https://doi.org/10.1016/j.jcma.2011.01.018.

    Article  PubMed  Google Scholar 

  44. Horowitz M, Whisnant RE, Jungreis C, Snyderman C, Levy EI, Kassam A. Temporary balloon occlusion and ethanol injection for preoperative embolization of carotid-body tumor. Ear Nose Throat J. 2002;81(8):536–8, 540, 542 passim.

    Article  PubMed  Google Scholar 

  45. Yilmaz S, Sindel T, Luleci E, Tuncar R. Preoperative embolization of carotid body tumors with microsphere particles. Ann Vasc Surg. 2003;17(6):697–8.. author reply 698

    Article  PubMed  Google Scholar 

  46. Abud DG, Mounayer C, Benndorf G, Piotin M, Spelle L, Moret J. Intratumoral injection of cyanoacrylate glue in head and neck paragangliomas. AJNR Am J Neuroradiol. 2004;25(9):1457–62.

    PubMed  PubMed Central  Google Scholar 

  47. Krishnamoorthy T, Gupta AK, Rajan JE, Thomas B. Stroke from delayed embolization of polymerized glue following percutaneous direct injection of a carotid body tumor. Korean J Radiol. 2007;8(3):249–53. https://doi.org/10.3348/kjr.2007.8.3.249.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Wanke I, Jackel MC, Goericke S, Panagiotopoulos V, Dietrich U, Forsting M. Percutaneous embolization of carotid paragangliomas using solely Onyx. AJNR Am J Neuroradiol. 2009;30(8):1594–7. https://doi.org/10.3174/ajnr.A1601.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Wiegand S, Kureck I, Chapot R, Sesterhenn AM, Bien S, Werner JA. Early side effects after embolization of a carotid body tumor using Onyx. J Vasc Surg. 2010;52(3):742–5. https://doi.org/10.1016/j.jvs.2010.04.026.

    Article  PubMed  Google Scholar 

  50. Elhammady MSA, Farhat H, Ziayee H, Aziz-Sultan MA. Direct percutaneous embolization of a carotid body tumor with Onyx. J Neurosurg. 2009;110(1):124–7. https://doi.org/10.3171/2008.4.17513.

    Article  PubMed  Google Scholar 

  51. Schick PM, Hieshima GB, White RA, et al. Arterial catheter embolization followed by surgery for large chemodectoma. Surgery. 1980;87(4):459–64.

    CAS  PubMed  Google Scholar 

  52. LaMuraglia GM, Fabian RL, Brewster DC, et al. The current surgical management of carotid body paragangliomas. J Vasc Surg. 1992;15(6):1035–8.

    Article  Google Scholar 

  53. Lim J-Y, Kim J, Kim SH, et al. Surgical treatment of carotid body paragangliomas: outcomes and complications according to the shamblin classification. Clin Exp Otorhinolaryngol. 2010;3(2):91–5. https://doi.org/10.3342/ceo.2010.3.2.91.

    Article  PubMed  PubMed Central  Google Scholar 

  54. Fruhmann J, Geigl JB, Konstantiniuk P, Cohnert TU. Paraganglioma of the carotid body: treatment strategy and SDH-gene mutations. Eur J Vasc Endovasc Surg. 2013;45(5):431–6. https://doi.org/10.1016/j.ejvs.2013.01.018.

    Article  CAS  PubMed  Google Scholar 

  55. Streeter GL. The development of the venous sinuses of the dura mater in the human embryo. Am J Anat. 1915;18(2):145–78.

    Article  Google Scholar 

  56. Litle VR, Reilly LM, Ramos TK. Preoperative embolization of carotid body tumors: when is it appropriate? Ann Vasc Surg. 1996;10(5):464–8. https://doi.org/10.1007/BF02000594.

    Article  CAS  PubMed  Google Scholar 

  57. Sahin MA, Jahollari A, Guler A, et al. Results of combined preoperative direct percutaneous embolization and surgical excision in treatment of carotid body tumors. Vasa. 2011;40(6):461–6. https://doi.org/10.1024/0301-1526/a000149.

    Article  CAS  PubMed  Google Scholar 

  58. Vogel TR, Mousa AY, Dombrovskiy VY, Haser PB, Graham AM. Carotid body tumor surgery: management and outcomes in the nation. Vasc Endovasc Surg. 2009;43(5):457–61. https://doi.org/10.1177/1538574409335274.

    Article  Google Scholar 

  59. Gwon JG, Kwon T-W, Kim H, Cho Y-P. Risk factors for stroke during surgery for carotid body tumors. World J Surg. 2011;35(9):2154–8. https://doi.org/10.1007/s00268-011-1167-7.

    Article  PubMed  Google Scholar 

  60. Power AH, Bower TC, Kasperbauer J, et al. Impact of preoperative embolization on outcomes of carotid body tumor resections. J Vasc Surg. 2012;56(4):979–89. https://doi.org/10.1016/j.jvs.2012.03.037.

    Article  PubMed  Google Scholar 

  61. Nazari I, Aarabi Moghaddam F, Zamani MM, Salimi J. Clinical characteristics and remedies in 45 Iranians with carotid body tumors. Acta Med Iran. 2012;50(5):339–43.

    PubMed  Google Scholar 

  62. Zeitler DM, Glick J, Har-El G. Preoperative embolization in carotid body tumor surgery: is it required? Ann Otol Rhinol Laryngol. 2010;119(5):279–83.

    Article  PubMed  Google Scholar 

  63. Dardik A, Eisele DW, Williams GM, Perler BA. A contemporary assessment of carotid body tumor surgery. Vasc Endovasc Surg. 2002;36(4):277–83. https://doi.org/10.1177/153857440203600405.

    Article  Google Scholar 

  64. Ozay B, Kurc E, Orhan G, et al. Surgery of carotid body tumour: 14 cases in 7 years. Acta Chir Belg. 2008;108(1):107–11.

    Article  CAS  PubMed  Google Scholar 

  65. Bercin S, Muderris T, Sevil E, Gul F, Kilicarslan A, Kiris M. Efficiency of preoperative embolization of carotid body tumor. Auris Nasus Larynx. 2015;42(3):226–30. https://doi.org/10.1016/j.anl.2014.10.013.

    Article  PubMed  Google Scholar 

  66. Fruhwirth J, Koch G, Hauser H, Gutschi S, Beham A, Kainz J. Paragangliomas of the carotid bifurcation: oncological aspects of vascular surgery. Eur J Surg Oncol. 1996;22(1):88–92.

    Article  CAS  PubMed  Google Scholar 

  67. Zhang T, Jiang W, Li Y, Li B, Yamakawa T. Perioperative approach in the surgical management of carotid body tumors. Ann Vasc Surg. 2012;26(6):775–82. https://doi.org/10.1016/j.avsg.2012.01.020.

    Article  PubMed  Google Scholar 

  68. Zhang J, Fan X, Zhen Y, et al. Impact of preoperative transarterial embolization of carotid body tumor: a single center retrospective cohort experience. Int J Surg. 2018;54(Pt A):48–52. https://doi.org/10.1016/j.ijsu.2018.04.032.

    Article  PubMed  Google Scholar 

  69. Ward PH, Liu C, Vinuela F, Bentson JR. Embolization: an adjunctive measure for removal of carotid body tumors. Laryngoscope. 1988;98(12):1287–91. https://doi.org/10.1288/00005537-198812000-00002.

    Article  CAS  PubMed  Google Scholar 

  70. Tikkakoski T, Luotonen J, Leinonen S, et al. Preoperative embolization in the management of neck paragangliomas. Laryngoscope. 1997;107(6):821–6.

    Article  CAS  PubMed  Google Scholar 

  71. Liapis CD, Evangelidakis EL, Papavassiliou VG, et al. Role of malignancy and preoperative embolization in the management of carotid body tumors. World J Surg. 2000;24(12):1526–30.

    Article  CAS  PubMed  Google Scholar 

  72. Kasper GC, Welling RE, Wladis AR, et al. A multidisciplinary approach to carotid paragangliomas. Vasc Endovasc Surg. 2006;40(6):467–74. https://doi.org/10.1177/1538574406290254.

    Article  Google Scholar 

  73. Liu D, Ma X, Li B, Zhang J. Clinical study of preoperative angiography and embolization of hypervascular neoplasms in the oral and maxillofacial region. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101(1):102–9. https://doi.org/10.1016/j.tripleo.2005.05.062.

    Article  PubMed  Google Scholar 

  74. Ikeda A, Shiga K, Katagiri K, et al. Multi-institutional survey of carotid body tumors in Japan. Oncol Lett. 2018;15(4):5318–24. https://doi.org/10.3892/ol.2018.7925.

    Article  PubMed  PubMed Central  Google Scholar 

  75. Texakalidis P, Charisis N, Giannopoulos S, et al. Role of preoperative embolization in carotid body tumor surgery: a systematic review and meta-analysis. In: World Neurosurg, vol. 129; 2019. p. 503–513.e2. https://doi.org/10.1016/j.wneu.2019.05.209.

    Chapter  Google Scholar 

  76. Jackson RS, Myhill JA, Padhya TA, McCaffrey JC, McCaffrey TV, Mhaskar RS. The effects of preoperative embolization on carotid body Paraganglioma surgery: a systematic review and meta-analysis. Otolaryngol Head Neck Surg. 2015;153(6):943–50. https://doi.org/10.1177/0194599815605323.

    Article  PubMed  Google Scholar 

  77. Abu-Ghanem S, Yehuda M, Carmel NN, Abergel A, Fliss DM. Impact of preoperative embolization on the outcomes of carotid body tumor surgery: a meta-analysis and review of the literature. Head Neck. 2016;38(Suppl 1):E2386–94. https://doi.org/10.1002/hed.24381.

    Article  PubMed  Google Scholar 

  78. Casasco A, Herbreteau D, Houdart E, et al. Devascularization of craniofacial tumors by percutaneous tumor puncture. AJNR Am J Neuroradiol. 1994;15(7):1233–9.

    CAS  PubMed  PubMed Central  Google Scholar 

  79. Chaloupka JC, Mangla S, Huddle DC, et al. Evolving experience with direct puncture therapeutic embolization for adjunctive and palliative management of head and neck hypervascular neoplasms. Laryngoscope. 1999;109(11):1864–72. https://doi.org/10.1097/00005537-199911000-00028.

    Article  CAS  PubMed  Google Scholar 

  80. Harman M, Etlik O, Unal O. Direct percutaneous embolization of a carotid body tumor with n-butyl cyanoacrylate: an alternative method to endovascular embolization. Acta Radiol. 2004;45(6):646–8.

    Article  CAS  PubMed  Google Scholar 

  81. Ozyer U, Harman A, Yildirim E, Aytekin C, Akay TH, Boyvat F. Devascularization of head and neck paragangliomas by direct percutaneous embolization. Cardiovasc Intervent Radiol. 2010;33(5):967–75. https://doi.org/10.1007/s00270-010-9803-4.

    Article  PubMed  Google Scholar 

  82. Elhammady MS, Peterson EC, Johnson JN, Aziz-Sultan MA. Preoperative onyx embolization of vascular head and neck tumors by direct puncture. World Neurosurg. 2012;77(5–6):725–30. https://doi.org/10.1016/j.wneu.2011.02.033.

    Article  PubMed  Google Scholar 

  83. Shah HM, Gemmete JJ, Chaudhary N, Pandey AS, Ansari SA. Preliminary experience with the percutaneous embolization of paragangliomas at the carotid bifurcation using only ethylene vinyl alcohol copolymer (EVOH) Onyx. J Neurointerv Surg. 2012;4(2):125–9. https://doi.org/10.1136/jnis.2010.003970.

    Article  PubMed  Google Scholar 

  84. Gemmete JJ, Chaudhary N, Pandey A, et al. Usefulness of percutaneously injected ethylene-vinyl alcohol copolymer in conjunction with standard endovascular embolization techniques for preoperative devascularization of hypervascular head and neck tumors: technique, initial experience, and correlation with surgical observations. AJNR Am J Neuroradiol. 2010;31(5):961–6. https://doi.org/10.3174/ajnr.A1936.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  85. Scanlon JM, Lustgarten JJ, Karr SB, Cahan JI. Successful devascularization of carotid body tumors by covered stent placement in the external carotid artery. J Vasc Surg. 2008;48(5):1322–4. https://doi.org/10.1016/j.jvs.2008.05.031.

    Article  PubMed  Google Scholar 

  86. San Norberto EM, Taylor JH, Carrera S, Vaquero C. Intraoperative embolization with poloxamer 407 during surgical resection of a carotid body tumor. J Vasc Surg. 2012;56(6):1782–5. https://doi.org/10.1016/j.jvs.2012.06.106.

    Article  PubMed  Google Scholar 

  87. Lybeert ML, van Andel JG, Eijkenboom WM, de Jong PC, Knegt P. Radiotherapy of paragangliomas. Clin Otolaryngol Allied Sci. 1984;9(2):105–9.

    Article  CAS  PubMed  Google Scholar 

  88. Mitchell DC, Clyne CA. Chemodectomas of the neck: the response to radiotherapy. Br J Surg. 1985;72(11):903–5. https://doi.org/10.1002/bjs.1800721119.

    Article  CAS  PubMed  Google Scholar 

  89. Evenson LJ, Mendenhall WM, Parsons JT, Cassisi NJ. Radiotherapy in the management of chemodectomas of the carotid body and glomus vagale. Head Neck. 1998;20(7):609–13.

    Article  CAS  PubMed  Google Scholar 

  90. Verniers DA, Keus RB, Schouwenburg PF, Bartelink H. Radiation therapy, an important mode of treatment for head and neck chemodectomas. Eur J Cancer. 1992;28A(6–7):1028–33. https://doi.org/10.1016/0959-8049(92)90448-b.

    Article  CAS  PubMed  Google Scholar 

  91. Sheehan JP, Tanaka S, Link MJ, et al. Gamma knife surgery for the management of glomus tumors: a multicenter study. J Neurosurg. 2012;117(2):246–54. https://doi.org/10.3171/2012.4.JNS11214.

    Article  PubMed  Google Scholar 

  92. Tse V, Sillanpaa J, Minn AY, et al. Glomus tumors treated with stereotactic radiosurgery: a retrospective study. J Radiosurg SBRT. 2017;5(1):73–81.

    PubMed  PubMed Central  Google Scholar 

  93. Gottfried ON, Liu JK, Couldwell WT. Comparison of radiosurgery and conventional surgery for the treatment of glomus jugulare tumors. Neurosurg Focus. 2004;17(2):E4.

    Article  PubMed  Google Scholar 

  94. Ivan ME, Sughrue ME, Clark AJ, et al. A meta-analysis of tumor control rates and treatment-related morbidity for patients with glomus jugulare tumors. J Neurosurg. 2011;114(5):1299–305. https://doi.org/10.3171/2010.9.JNS10699.

    Article  PubMed  Google Scholar 

  95. Karaman E, Isildak H, Yilmaz M, et al. Management of paragangliomas in otolaryngology practice: review of a 7-year experience. J Craniofac Surg. 2009;20(4):1294–7. https://doi.org/10.1097/SCS.0b013e3181ae213b.

    Article  PubMed  Google Scholar 

  96. Suarez C, Rodrigo JP, Mendenhall WM, et al. Carotid body paragangliomas: a systematic study on management with surgery and radiotherapy. Eur Arch Otorhinolaryngol. 2014;271(1):23–34. https://doi.org/10.1007/s00405-013-2384-5.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Brigham and Women’s Hospital, Harvard Medical School, Department of Neurosurgery, Boston, MA, USA

    Karen S. Chen, Juan Vicenty-Padilla & M. Ali Aziz-Sultan

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  1. Karen S. Chen
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  2. Juan Vicenty-Padilla
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  3. M. Ali Aziz-Sultan
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Correspondence to Karen S. Chen .

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Editors and Affiliations

  1. Department of Neurosurgery, University of Virginia, Charlottesville, VA, USA

    Min S. Park

  2. Department of Neurosurgery, University of Virginia, Charlottesville, VA, USA

    M. Yashar S. Kalani

  3. Department of Neurology, University of Utah, Salt Lake City, UT, USA

    Adam de Havenon

  4. Department of Radiology, University of Utah, Salt Lake City, UT, USA

    J. Scott McNally

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Chen, K.S., Vicenty-Padilla, J., Aziz-Sultan, M.A. (2020). Carotid Body Tumors: Pre-operative Management and a Review of the Literature. In: Park, M., Kalani, M., de Havenon, A., McNally, J. (eds) Carotid Artery Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-41138-1_17

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  • DOI: https://doi.org/10.1007/978-3-030-41138-1_17

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