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New Therapies to Prevent or Cure Auditory Disorders pp 89–111Cite as

Approaches to Regenerate Hair Cell and Spiral Ganglion Neuron in the Inner Ear

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Abstract

The cochlear hair cells are the primary sensory structures accountable for interpreting the mechanical sound waves by converting into neural impulses. The degeneration of these sensory hair cells is irreversible in mammals and if severe damage occurs to the HCs, the deficit may result in permanent hearing loss. The present hearing rehabilitation approaches, including hearing aids and cochlear implants, partially restore hearing mechanism; however, the quality of perceived sound does not really match with the normal hearing ear. Therefore, much attention has been paid on developing regenerative therapies such as gene therapy and stem cells therapy to treat the damaged organ of Corti. These therapies are promising to stimulate the mechanism of regeneration/development in hair cells and spiral ganglion neuron, thus to recover deafness. This chapter specifically presents these two strategies and comprehensively explain their current applications to regenerate hair cells and spiral ganglion neurons in the mammalian inner ear.

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Abbreviations

AAV:

Adeno-associated virus

Ad:

Adenovirus

BDNF:

Brain-derived neurotrophic factor

GDNF:

Glial-derived neurotrophic factor

HCs:

Hair cells

iPSCs:

Inducible pluripotent stem cells

NT3:

Neurotrophin 3

SCs:

Supporting cells

SGNs:

Spiral ganglion neurons

SNHL:

Sensorineural hearing loss

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Authors and Affiliations

  1. Department of Biotechnology, Federal Urdu University of Arts, Science and Technology, Gulshan-e-Iqbal Campus, Karachi, Pakistan

    Muhammad Waqas

  2. MOE Key Laboratory of Developmental Genes and Human Disease, Institute of Life Sciences, Southeast University, Nanjing, China

    Muhammad Waqas & Renjie Chai

  3. Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, China

    Renjie Chai

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  1. CILcare, Advanced Solution for Drug Development in Hearing Disorder, Montpellier, France

    Sylvie Pucheu

  2. Center for Hearing and Deafness, University at Buffalo, Buffalo, NY, USA

    Kelly E. Radziwon

  3. Center for Hearing and Deafness, University at Buffalo, Buffalo, NY, USA

    Richard Salvi

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Waqas, M., Chai, R. (2020). Approaches to Regenerate Hair Cell and Spiral Ganglion Neuron in the Inner Ear. In: Pucheu, S., Radziwon, K., Salvi, R. (eds) New Therapies to Prevent or Cure Auditory Disorders. Springer, Cham. https://doi.org/10.1007/978-3-030-40413-0_4

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