Abstract
Diabetes mellitus is one of the leading chronic metabolic syndromes, which consists of many complications and risk factors, and the condition of hyperglycaemia leads to other organs to dysfunction. Despite the new modalities available in diabetes management, the effective therapeutic drug delivery is an actual threat faced in the current scenario. There exist many threats in the drug delivery system from powder mixtures to capsules of medicine in the management of diabetes. The drug delivery system is a major target for exaggerated therapeutic approach with lesser toxicity and side effects. In recent days, the breakthrough of advancements in the field of science and technology is refined to the novel drug delivery system with the synthesis of nanoemulsions in maintaining the complexity of diabetes.
The blend of nanotechnology in the drug delivery system with the nanoemulsion (NE) formulations is widely noted as safe on account of its greater advantages such as good stability, bioavailability of drugs, and preventing the hydrolysis of drugs, which in turn acts as a good transporter of the drug particle. With the aforementioned information, this chapter reviews the potent curative drug delivery on various nanoemulsion formulations in managing diabetes mellitus.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Akhtar J, Hussain Siddiqui H, Fareed S, Khalid M, Aqil M (2016) Drug delivery nanoemulsion: for improved oral delivery of repaglinide Nanoemulsion: for improved oral delivery of repaglinide. Drug Deliv 23(6):2026–2034. https://doi.org/10.3109/10717544.2015.1077290
Chellapa P, Mohamed A, Keleb E, Elmahgoubi A, Eid A, Issa Y, Elmarzugi N (2015) Nanoemulsion and nanoemulgel as a topical formulation. IOSR J Pharm 5(10):43–47
Chime SA, Kenechukwu FC, Attama AA (2014) Nanoemulsions — advances in formulation, characterization and applications in drug delivery, Intech Open limited, London.
Deepa V, Sridhar R, Neelakanta Reddy P, Balakrishna MP (2012) Development, characterization, efficacy and repeated dose toxicity of nanoemulsified ethanolic extract of Enicostemma littorale in Streptozotocin-induced diabetes rats. Int J Phytomedicine 4(1):70–89. https://doi.org/10.5138/ijpm.v4i1.511
Fitipaldi H, McCarthy MI, Florez JC, Franks PW (2018) A global overview of precision medicine in type 2 diabetes. Diabetes 67(10):1911–1922. https://doi.org/10.2337/dbi17-0045
Hassan KAM, Mujtaba MA (2017) Oral nano-emulsion of fenugreek oil for treatment of diabetes. Int J Pharm Sci Res 8(7):3151–3154. https://doi.org/10.13040/IJPSR.0975-8232
Hatanaka J, Chikamori H, Sato H, Uchida S, Debari K, Onoue S, Yamada S (2010) Physicochemical and pharmacological characterization of α-tocopherol-loaded nano-emulsion system. Int J Pharm 396(1–2):188–193. https://doi.org/10.1016/j.ijpharm.2010.06.017
Hussein J, El-bana M, Refaat E, El-naggar ME (2017) Synthesis of carvacrol-based nanoemulsion for treating neurodegenerative disorders in experimental diabetes. J Funct Foods 37:441–448. https://doi.org/10.1016/j.jff.2017.08.011
Ibupoto ZH, Khun K, Lu J, Willander M (2013) The synthesis of CuO nanoleaves, structural characterization, and their glucose sensing application. Appl Phys Lett 102(10):103701. https://doi.org/10.1063/1.4795135
IDF Diabetes Atlas (2017) In: Karuranga S, da R. Fernandes J, Huang Y, Malanda B (eds) International Diabetes Federation, 2017, 8th ed. IDF Diabetes Atlas, Brussels. https://doi.org/10.1016/S0140-6736(16)31679-8
Langer R (1990) New methods of drug delivery. Science 249(4976):1527–1533. https://doi.org/10.1126/science.2218494
Ledet G, Pamujula S, Walker V, Simon S, Graves R, Mandal TK (2014) Development and in vitro evaluation of a nanoemulsion for transcutaneous delivery. Drug Dev Ind Pharm 40(3):370–379. https://doi.org/10.3109/03639045.2012.763137
Li CN, Gupta M (2019) Transdermal drug delivery systems in diabetes management: a review. Asian J Pharm Sci. https://doi.org/10.1016/j.ajps.2019.04.006
Li, P., Tan, A., Prestidge, C. A., Nielsen, H. M., & Müllertz, A. (2014). Self-nanoemulsifying drug delivery systems for oral insulin delivery: In vitro and in vivo evaluations of enteric coating and drug loading. International Journal of Pharmaceutics, 477(1), 390–398. https://doi.org/10.1016/j.ijpharm.2014.10.039
Li X, Qi J, Xie Y, Zhang X, Hu S, Xu Y, Wu W (2013) Nanoemulsions coated with alginate/chitosan as oral insulin delivery systems : preparation, characterization, and hypoglycemic effect in rats. Int J Nanomedicine 2013(8):23–32
Lovelyn C, Attama AA (2011) Current state of nanoemulsions in drug delivery. J Biomater Nanobiotechnol 02(05):626–639. https://doi.org/10.4236/jbnb.2011.225075
Mahendran V, Philip J (2014) Non-enzymatic glucose detection using magnetic nanoemulsions. Appl Phys Lett 105(12):110–123. https://doi.org/10.1063/1.4896522
Mostafa DM, El-alim SHA, Asfour MH, Al-okbi SY, Mohamed DA, Awad G (2015) Transdermal nanoemulsions of Foeniculum vulgare Mill. essential oil: preparation, characterization and evaluation of antidiabetic potential. J Drug Delivery Sci Technol 29:99. https://doi.org/10.1016/j.jddst.2015.06.021
Nikam TH, Patil MP, Patil SS, Vadnere GP, Lodhi S (2018) Nanoemulsion: a brief review on development and application in parenteral drug delivery. Adv Pharm J 3(2):43–54. https://doi.org/10.31024/apj.2018.3.2.2
Oliveira C, Bertato M., Wajchenberg, B, Lerario A, Maranhão R (2009) Plasma kinetics of the esterified cholesterol of an ldllike nanoemulsion in patients with type 2 diabetes mellitus. https://doi.org/10.1016/s1567-5688(09)70378-2
Paul D, Dey TK, Mukherjee S, Ghosh M, Dhar P (2014) Comparative prophylactic effects of α-eleostearic acid rich nano and conventional emulsions in induced diabetic rats. J Food Sci Technol 51(9):1724–1736. https://doi.org/10.1007/s13197-014-1257-2
Prasad PS, Imam SS, Aqil M, Sultana Y, Ali A (2016) QbD-based carbopol transgel formulation: characterization, pharmacokinetic assessment and therapeutic efficacy in diabetes. Drug Deliv 23(3):1057–1066. https://doi.org/10.3109/10717544.2014.936536
Prihapsara F (2017) Antidiabetic activity of self nanoemulsifying drug delivery system from bay leaves (Eugenia polyantha Wight) ethyl acetate fraction. In: IOP conference series: Materials science and engineering. IOP Publishing, pp 0–6. https://doi.org/10.1088/1742-6596/755/1/011001
Rai VK, Mishra N, Yadav KS, Yadav NP (2018) Nanoemulsion as pharmaceutical carrier for dermal and transdermal drug delivery: formulation development, stability issues, basic considerations and applications. J Control Release. Elsevier B.V. https://doi.org/10.1016/j.jconrel.2017.11.049
Ranganathan N, Mahalingam G (2019) 2,4,6-Triphenylaniline nanoemulsion formulation, optimization, and its application in type 2 diabetes mellitus. J Cell Physiol:1–12. https://doi.org/10.1002/jcp.28814
Rodrigues FVS, Diniz LS, Sousa RMG, Honorato TD, Simão DO, Araújo CRM, Siqueira-Moura MP (2018) Preparation and characterization of nanoemulsion containing a natural naphthoquinone. Quimica Nova 41(7):756–761. https://doi.org/10.21577/0100-4042.20170247
Sarker D (2005) Engineering of nanoemulsions for drug delivery. Curr Drug Deliv 2(4):297–310. https://doi.org/10.2174/156720105774370267
Savardekar P, Bajaj A (2016) Nanoemulsions-a review. Int J Res Pharm Chem 6(2):312–322
Simonazzi A, Cid AG, Villegas M, Romero AI, Palma SD, Bermúdez JM (2018) Nanotechnology applications in drug controlled release. In: Drug targeting and stimuli sensitive drug delivery systems. https://doi.org/10.1016/b978-0-12-813689-8.00003-3
Singh Y, Meher JG, Raval K, Khan FA, Chaurasia M, Jain NK, Chourasia MK (2017) Nanoemulsion: concepts, development and applications in drug delivery. J Control Release 252:28–49. https://doi.org/10.1016/j.jconrel.2017.03.008
Tiwari P (2015) Recent trends in therapeutic approaches for diabetes management: a comprehensive update. J Diabetes Res 2015:1. https://doi.org/10.1155/2015/340838
Tiwari G, Tiwari R, Sriwastawa B, Bhati L, Pandey S, Pandey P, Bannerjee SK (2012) Drug delivery systems: an updated review. Int J Pharm Investig 2(1):2–11. https://doi.org/10.4103/2230-973X.96920
Veiseh O, Tang BC, Whitehead KA, Anderson DG, Langer R (2015) Managing diabetes with nanomedicine: challenges and opportunities HHS Public Access. Nat Rev Drug Discov 14(1):45–57. https://doi.org/10.1038/nrd4477
WHO 2016 (2016) Global report on diabetes. World Health Organization (58). https://doi.org/10.1128/AAC.03728-14
Woldu MA, Lenjisa JL (2017) Nanoparticles and the new era in diabetes management. Int J Basic Clin Pharmacol 3(2):277–284. https://doi.org/10.5455/2319-2003.ijbcp20140405
Yu J, Zhang Y, Bomba H, Gu Z (2016) Stimuli-responsive delivery of therapeutics for diabetes treatment. Bioeng Transl Med 1(3):323–337. https://doi.org/10.1002/btm2.10036
Acknowledgement
The authors are thankful to the Chancellor of Vellore Institute of Technology, Tamil Nadu, India, for providing the required expertise to carry out the present research work.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Devaraj, A., Mahalingam, G. (2020). Nanoemulsion Formulation as an Effective Therapeutic Drug Delivery System in Diabetes Mellitus. In: Patra, J., Fraceto, L., Das, G., Campos, E. (eds) Green Nanoparticles. Nanotechnology in the Life Sciences. Springer, Cham. https://doi.org/10.1007/978-3-030-39246-8_16
Download citation
DOI: https://doi.org/10.1007/978-3-030-39246-8_16
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-39245-1
Online ISBN: 978-3-030-39246-8
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)