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Fertility Considerations for Gender Diverse Youth

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Pediatric Gender Identity

Abstract

Hormonal interventions for transgender and gender-diverse (TGD) youth may have a negative impact on fertility. Reversible gonadotropin-releasing hormone analogs do not appear to have significant effects on fertility. Partially irreversible hormonal interventions like estrogen and testosterone may or may not impair fertility. Guidelines published by the World Professional Association for Transgender Health and the Endocrine Society state that counseling about potential risks and fertility preservation options should occur prior to initiating these therapies. This chapter will characterize what is known regarding infertility risk associated with gonadotropin-releasing hormone agonists, testosterone, and estrogen; outline fertility preservation options for birth-assigned males and females; describe research on fertility-related attitudes and psychosocial considerations among TGD adults and youth; and highlight ethical and financial considerations.

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References

  1. Spack NP, Edwards-Leeper L, Feldman HA, Leibowitz S, Mandel F, Diamond DA, et al. Children and adolescents with gender identity disorder referred to a pediatric medical center. Pediatrics. 2012;129(3):418–25.

    Article  PubMed  Google Scholar 

  2. Aitken M, Steensma TD, Blanchard R, VanderLaan DP, Wood H, Fuentes A, et al. Evidence for an altered sex ratio in clinic-referred adolescents with gender dysphoria. J Sex Med. 2015;12(3):756–63.

    Article  PubMed  Google Scholar 

  3. Hudson MM, Ness KK, Gurney JG, Mulrooney DA, Chemaitilly W, Krull KR, et al. Clinical ascertainment of health outcomes among adults treated for childhood cancer. JAMA. 2013;309(22):2371–81.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Chow EJ, Stratton KL, Leisenring WM, Oeffinger KC, Sklar CA, Donaldson SS, et al. Pregnancy after chemotherapy in male and female survivors of childhood cancer treated between 1970 and 1999: a report from the childhood cancer survivor study cohort. Lancet Oncol. 2016;17(5):567–76.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Johnson EK, Finlayson C, Rowell EE, Gosiengfiao Y, Pavone ME, Lockart B, et al. Fertility preservation for pediatric patients: current state and future possibilities. J Urol. 2017;198:186.

    Article  PubMed  Google Scholar 

  6. Nahata L, Quinn GP, Tishelman AC, Section On E. Counseling in pediatric populations at risk for infertility and/or sexual function concerns. Pediatrics. 2018;142(2):pii: e20181435.

    Article  Google Scholar 

  7. Stein DM, Victorson DE, Choy JT, Waimey KE, Pearman TP, Smith K, et al. Fertility preservation preferences and perspectives among adult male survivors of pediatric cancer and their parents. J Adolesc Young Adult Oncol. 2014;3(2):75–82.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Armuand GM, Wettergren L, Rodriguez-Wallberg KA, Lampic C. Desire for children, difficulties achieving a pregnancy, and infertility distress 3 to 7 years after cancer diagnosis. Support Care Cancer. 2014;22(10):2805–12.

    Article  PubMed  PubMed Central  Google Scholar 

  9. De Sutter P, Kira K, Verschoor A, Hotimsky A. The desire to have children and the 101 preservation of fertility in transsexual women: a survey. Int J Transgenderism. 2002;6(3):97–03.

    Google Scholar 

  10. Wierckx K, Van Caenegem E, Pennings G, Elaut E, Dedecker D, Van de Peer F, et al. Reproductive wish in transsexual men. Hum Reprod. 2012;27(2):483–7.

    Article  PubMed  Google Scholar 

  11. Tornello SL, Bos H. Parenting intentions among transgender individuals. LGBT Health. 2017;4(2):115–20.

    Article  PubMed  Google Scholar 

  12. von Doussa H, Power J, Riggs D. Imagining parenthood: the possibilities and experiences of parenthood among transgender people. Cult Health Sex. 2015;17(9):1119–31.

    Article  Google Scholar 

  13. Auer MK, Fuss J, Nieder TO, Briken P, Biedermann SV, Stalla GK, et al. Desire to have children among transgender people in Germany: a cross-sectional multi-center study. J Sex Med. 2018;15(5):757–67.

    Article  PubMed  Google Scholar 

  14. Coleman E, Bockting W, Botzer M, Cohen-Kettenis P, DeCuypere G, Feldman J, et al. Standards of care for the health of transsexual, transgender, and gender-nonconforming people, version 7. Int J Transgenderism. 2012;13(4):165–232.

    Article  Google Scholar 

  15. Hembree WC, Cohen-Kettenis PT, Gooren L, Hannema SE, Meyer WJ, Murad MH, et al. Endocrine treatment of gender-dysphoric/gender-incongruent persons: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2017;102(11):3869–903.

    Article  PubMed  Google Scholar 

  16. Ethics Committee of the American Society for Reproductive M. Access to fertility services by transgender persons: an ethics committee opinion. Fertil Steril. 2015;104(5):1111–5.

    Article  Google Scholar 

  17. Chen M, Eugster EA. Central precocious puberty: update on diagnosis and treatment. Pediatr Drugs. 2015;17(4):273–81.

    Article  Google Scholar 

  18. Neely EK, Lee PA, Bloch CA, Larsen L, Yang D, Mattia-Goldberg C, et al. Leuprolide acetate 1-month depot for central precocious puberty: hormonal suppression and recovery. Int J Pediatr Endocrinol. 2011;2010(1):398639.

    Article  PubMed Central  Google Scholar 

  19. Schagen SE, Cohen-Kettenis PT, Delemarre-van de Waal HA, Hannema SE. Efficacy and safety of gonadotropin-releasing hormone agonist treatment to suppress puberty in gender dysphoric adolescents. J Sex Med. 2016;13(7):1125–32.

    Article  PubMed  Google Scholar 

  20. De Roo C, Lierman S, Tilleman K, Peynshaert K, Braeckmans K, Caanen M, et al. Ovarian tissue cryopreservation in female-to-male transgender people: insights into ovarian histology and physiology after prolonged androgen treatment. Reprod Biomed Online. 2017;34(6):557–66.

    Article  PubMed  Google Scholar 

  21. Spinder T, Spijkstra JJ, van den Tweel JG, Burger CW, van Kessel H, Hompes PG, et al. The effects of long term testosterone administration on pulsatile luteinizing hormone secretion and on ovarian histology in eugonadal female to male transsexual subjects. J Clin Endocrinol Metab. 1989;69(1):151–7.

    Article  CAS  PubMed  Google Scholar 

  22. Ikeda K, Baba T, Noguchi H, Nagasawa K, Endo T, Kiya T, et al. Excessive androgen exposure in female-to-male transsexual persons of reproductive age induces hyperplasia of the ovarian cortex and stroma but not polycystic ovary morphology. Hum Reprod. 2013;28(2):453–61.

    Article  CAS  PubMed  Google Scholar 

  23. Baba T, Endo T, Honnma H, Kitajima Y, Hayashi T, Ikeda H, et al. Association between polycystic ovary syndrome and female-to-male transsexuality. Hum Reprod. 2007;22(4):1011–6.

    Article  PubMed  Google Scholar 

  24. Hunter MH, Sterrett JJ. Polycystic ovary syndrome: it’s not just infertility. Am Fam Physician. 2000;62(5):1079–88.

    CAS  PubMed  Google Scholar 

  25. Light AD, Obedin-Maliver J, Sevelius JM, Kerns JL. Transgender men who experienced pregnancy after female-to-male gender transitioning. Obstet Gynecol. 2014;124(6):1120–7.

    Article  CAS  PubMed  Google Scholar 

  26. Finer LB, Zolna MR. Declines in unintended pregnancy in the United States, 2008–2011. N Engl J Med. 2016;374(9):843–52.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Gabrilove JL, Nicolis GL, Mitty HA, Sohval AR. Feminizing interstitial cell tumor of the testis: personal observations and a review of the literature. Cancer. 1975;35(4):1184–202.

    Article  CAS  PubMed  Google Scholar 

  28. Oshima H, Sarada T, Ochiai K, Tamaoki B. Effects of a synthetic estrogen upon steroid bioconversion in vitro in testes of patients with prostatic cancer. Investig Urol. 1974;12(1):43–9.

    CAS  Google Scholar 

  29. Schneider F, Kliesch S, Schlatt S, Neuhaus N. Andrology of male-to-female transsexuals: influence of cross-sex hormone therapy on testicular function. Andrology. 2017;5(5):873–80.

    Article  CAS  PubMed  Google Scholar 

  30. Schulze C. Response of the human testis to long-term estrogen treatment: morphology of sertoli cells, leydig cells and spermatogonial stem cells. Cell Tissue Res. 1988;251(1):31–43.

    Article  CAS  PubMed  Google Scholar 

  31. Thiagaraj D, Gunasegaram R, Loganath A, Peh KL, Kottegoda SR, Ratnam SS. Histopathology of the testes from male transsexuals on oestrogen therapy. Ann Acad Med Singap. 1987;16(2):347–8.

    CAS  PubMed  Google Scholar 

  32. Leavy M, Trottmann M, Liedl B, Reese S, Stief C, Freitag B, et al. Effects of elevated beta-estradiol levels on the functional morphology of the testis – new insights. Sci Rep. 2017;7:39931.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Schneider F, Neuhaus N, Wistuba J, Zitzmann M, Hess J, Mahler D, et al. Testicular functions and clinical characterization of patients with gender dysphoria (GD) undergoing sex reassignment surgery (SRS). J Sex Med. 2015;12(11):2190–200.

    Article  CAS  PubMed  Google Scholar 

  34. Ethics Committee of American Society for Reproductive Medicine. Fertility preservation and reproduction in patients facing gonadotoxic therapies: a committee opinion. Fertil Steril. 2013;100(5):1224–31.

    Article  Google Scholar 

  35. Oktay K, Bedoschi G. Oocyte cryopreservation for fertility preservation in postpubertal female children at risk for premature ovarian failure due to accelerated follicle loss in turner syndrome or cancer treatments. J Pediatr Adolesc Gynecol. 2014;27(6):342–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Practice Committees of American Society for Reproductive M, Society for Assisted Reproductive T. Mature oocyte cryopreservation: a guideline. Fertil Steril. 2013;99(1):37–43.

    Article  Google Scholar 

  37. Practice Committee of American Society for Reproductive M. Ovarian tissue cryopreservation: a committee opinion. Fertil Steril. 2014;101(5):1237–43.

    Article  Google Scholar 

  38. McCracken K, Nahata L. Fertility preservation in children and adolescents: current options and considerations. Curr Opin Obstet Gynecol. 2017;29:283.

    Article  PubMed  Google Scholar 

  39. Nahata L, Chen D, Moravek MB, Quinn GP, Sutter ME, Taylor J, Tishelman AC, Gomez-Lobo V. Understudied and under-reported: fertility issues in transgender youth—a narrative review. J Pediatr. 2019;205:265–71.

    Google Scholar 

  40. Donnez J, Dolmans MM. Ovarian cortex transplantation: 60 reported live births brings the success and worldwide expansion of the technique towards routine clinical practice. J Assist Reprod Genet. 2015;32(8):1167–70.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Jensen AK, Macklon KT, Fedder J, Ernst E, Humaidan P, Andersen CY. 86 successful births and 9 ongoing pregnancies worldwide in women transplanted with frozen-thawed ovarian tissue: focus on birth and perinatal outcome in 40 of these children. J Assist Reprod Genet. 2017;34(3):325–36.

    Article  PubMed  Google Scholar 

  42. Donnelly L. Woman gives birth to baby using ovary frozen in her childhood in ‘world first’. The Telegraph. 2016.

    Google Scholar 

  43. Oktay K, Harvey BE, Partridge AH, Quinn GP, Reinecke J, Taylor HS, et al. Fertility preservation in patients with cancer: ASCO clinical practice guideline update. J Clin Oncol. 2018;36:1994–2001. https://doi.org/10.1200/JCO.2018.78.1914.

    Article  PubMed  Google Scholar 

  44. Demeestere I, Simon P, Dedeken L, Moffa F, Tsépélidis S, Brachet C, et al. Live birth after autograft of ovarian tissue cryopreserved during childhood. Hum Reprod. 2015;30(9):2107–9.

    Article  PubMed  Google Scholar 

  45. Ladanyi C, Mor A, Christianson MS, Dhillon N, Segars JH. Recent advances in the field of ovarian tissue cryopreservation and opportunities for research. J Assist Reprod Genet. 2017;34(6):709–22.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Vadaparampil S, Quinn G, King L, Wilson C, Nieder M. Barriers to fertility preservation among pediatric oncologists. Patient Educ Couns. 2008;72(3):402–10.

    Article  PubMed  Google Scholar 

  47. Chapple A, Salinas M, Ziebland S, McPherson A, Macfarlane A. Fertility issues: the perceptions and experiences of young men recently diagnosed and treated for cancer. J Adolesc Health. 2007;40(1):69–75.

    Article  PubMed  Google Scholar 

  48. Crawshaw MA, Glaser AW, Hale JP, Sloper P. Young males’ experiences of sperm banking following a cancer diagnosis – a qualitative study. Hum Fertil. 2008;11(4):238–45.

    Article  Google Scholar 

  49. Crawshaw MA, Glaser AW, Pacey AA. The use of pornographic materials by adolescent male cancer patients when banking sperm in the UK: legal and ethical dilemmas. Hum Fertil. 2007;10(3):159–63.

    Article  Google Scholar 

  50. Klosky JL, Wang F, Russell KM, Zhang H, Flynn JS, Huang L, et al. Prevalence and predictors of sperm banking in adolescents newly diagnosed with cancer: examination of adolescent, parent, and provider factors influencing fertility preservation outcomes. J Clin Oncol. 2017;35:3830–6. https://doi.org/10.1200/JCO.2016.70.4767.

    Article  PubMed  PubMed Central  Google Scholar 

  51. Adank MC, van Dorp W, Smit M, van Casteren NJ, Laven JS, Pieters R, et al. Electroejaculation as a method of fertility preservation in boys diagnosed with cancer: a single-center experience and review of the literature. Fertil Steril. 2014;102(1):199–205.e1.

    Article  PubMed  Google Scholar 

  52. Moss JL, Choi AW, Fitzgerald Keeter MK, Brannigan RE. Male adolescent fertility preservation. Fertil Steril. 2016;105(2):267–73.

    Article  PubMed  Google Scholar 

  53. Keene DJ, Sajjad Y, Makin G, Cervellione RM. Sperm banking in the United Kingdom is feasible in patients 13 years old or older with cancer. J Urol. 2012;188(2):594–7.

    Article  PubMed  Google Scholar 

  54. Hagenas I, Jorgensen N, Rechnitzer C, Sommer P, Holm M, Schmiegelow K, et al. Clinical and biochemical correlates of successful semen collection for cryopreservation from 12-18-year-old patients: a single-center study of 86 adolescents. Hum Reprod. 2010;25(8):2031–8.

    Article  PubMed  Google Scholar 

  55. Wyns C, Collienne C, Shenfield F, Robert A, Laurent P, Roegiers L, et al. Fertility preservation in the male pediatric population: factors influencing the decision of parents and children. Hum Reprod. 2015;30(9):2022–30.

    Article  CAS  PubMed  Google Scholar 

  56. Wyns C, Curaba M, Vanabelle B, Van Langendonckt A, Donnez J. Options for fertility preservation in prepubertal boys. Hum Reprod Update. 2010;16(3):312–28.

    Article  PubMed  Google Scholar 

  57. Gassei K, Orwig KE. Experimental methods to preserve male fertility and treat male factor infertility. Fertil Steril. 2016;105(2):256–66.

    Article  PubMed  Google Scholar 

  58. M Russell A, Galvin KM, Harper MM, Clayman ML. A comparison of heterosexual and LGBTQ cancer survivors’ outlooks on relationships, family building, possible infertility, and patient-doctor fertility risk communication. J Cancer Surviv. 2016;10(5):935–42.

    Article  PubMed  Google Scholar 

  59. Riggs DW, Power J, von Doussa H. Parenting and Australian trans and gender diverse people: an exploratory survey. Int J Transgenderism. 2016;17(2):59–65.

    Article  Google Scholar 

  60. Chen D, Matson M, Macapagal K, Johnson EK, Rosoklija I, Finlayson C, et al. Attitudes toward fertility and reproductive health among transgender and gender-nonconforming adolescents. J Adolesc Health. 2018;63:62.

    Article  PubMed  PubMed Central  Google Scholar 

  61. Strang JF, Jarin J, Call D, Clark B, Wallace GL, Anthony LG, et al. Transgender youth fertility attitudes questionnaire: measure development in nonautistic and autistic transgender youth and their parents. J Adolesc Health. 2018;62:128–35.

    Article  PubMed  Google Scholar 

  62. Nahata L, Tishelman AC, Caltabellotta NM, Quinn GP. Low fertility preservation utilization among transgender youth. J Adolesc Health. 2017;61:40.

    Article  PubMed  Google Scholar 

  63. Chen D, Simons L, Johnson EK, Lockart BA, Finlayson C. Fertility preservation for transgender adolescents. J Adolesc Health. 2017;61:120.

    Article  PubMed  PubMed Central  Google Scholar 

  64. Reisner SL, Vetters R, Leclerc M, Zaslow S, Wolfrum S, Shumer D, et al. Mental health of transgender youth in care at an adolescent urban community health center: a matched retrospective cohort study. J Adolesc Health. 2015;56(3):274–9.

    Article  PubMed  PubMed Central  Google Scholar 

  65. Nahata L, Quinn GP, Caltabellotta NM, Tishelman AC. Mental health concerns and insurance denials among transgender adolescents. LGBT Health. 2017;4:188–93.

    Article  PubMed  Google Scholar 

  66. de Vries AL, McGuire JK, Steensma TD, Wagenaar EC, Doreleijers TA, Cohen-Kettenis PT. Young adult psychological outcome after puberty suppression and gender reassignment. Pediatrics. 2014;134(4):696–704.

    Article  PubMed  Google Scholar 

  67. Hudson J, Nahata L, Dietz E, Quinn GP. Fertility counseling for transgender AYAs. Clin Pract Pediatr Psychol. 2018;6(1):84–92.

    Article  PubMed  Google Scholar 

  68. Chen D, Simons L. Ethical considerations in fertility preservation for transgender youth: a case illustration. Clin Pract Pediatr Psychol. 2018;6(1):93–100.

    Article  PubMed  PubMed Central  Google Scholar 

  69. Nahata L, Campo-Engelstein LT, Tishelman A, Quinn GP, Lantos JD. Fertility preservation for a transgender teenager. Pediatrics. 2018;142:pii: e20173142.

    Article  Google Scholar 

  70. Steinberg L, Cauffman E. Maturity of judgment in adolescence: psychosocial factors in adolescent decision making. Law Hum Behav. 1996;20(3):249–72.

    Article  Google Scholar 

  71. Cauffman E, Steinberg L. (Im)maturity of judgment in adolescence: why adolescents may be less culpable than adults. Behav Sci Law. 2000;18(6):741–60.

    Article  CAS  PubMed  Google Scholar 

  72. Marcell AV, Burstein GR, Committee OA. Sexual and reproductive health care services in the pediatric setting. Pediatrics. 2017;140(5):e20172858.

    Article  PubMed  Google Scholar 

  73. Katz AL, Webb SA, Committee OB. Informed consent in decision-making in pediatric practice. Pediatrics. 2016;138(2):pii: e20161485.

    Article  Google Scholar 

  74. Shumer DE, Reisner SL, Edwards-Leeper L, Tishelman A. Evaluation of asperger syndrome in youth presenting to a gender dysphoria clinic. LGBT Health. 2016;3(5):387–90.

    Article  PubMed  PubMed Central  Google Scholar 

  75. Mersereau JE, Goodman LR, Deal AM, Gorman JR, Whitcomb BW, Su HI. To preserve or not to preserve: how difficult is the decision about fertility preservation? Cancer. 2013;119(22):4044–50.

    Article  PubMed  Google Scholar 

  76. Cardozo ER, Huber WJ, Stuckey AR, Alvero RJ. Mandating coverage for fertility preservation – a step in the right direction. N Engl J Med. 2017;377(17):1607–9.

    Article  PubMed  Google Scholar 

  77. Levine J, Stern CJ. Fertility preservation in adolescents and young adults with cancer. J Clin Oncol. 2010;28(32):4831–41.

    Article  PubMed  Google Scholar 

  78. Kelvin JF, Thom B, Benedict C, Carter J, Corcoran S, Dickler MN, et al. Cancer and fertility program improves patient satisfaction with information received. J Clin Oncol. 2016;34(15):1780–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  79. Alliance for Fertility Preservation [cited 2017]. Available from: http://www.allianceforfertilitypreservation.org/advocacy/state-legislation.

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Nahata, L., Valentine, A., Tishelman, A.C. (2020). Fertility Considerations for Gender Diverse Youth. In: Forcier, M., Van Schalkwyk, G., Turban, J. (eds) Pediatric Gender Identity. Springer, Cham. https://doi.org/10.1007/978-3-030-38909-3_15

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