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Total Marrow and Lymphoid Irradiation in Haploidentical Hematopoietic Cell Transplant

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Total Marrow Irradiation

Abstract

Allogeneic hematopoietic cell transplant (HCT) is the only available option for potential cure of high-risk hematological malignancies. Only about half of the candidates for HCT would have a human leukocyte antigen (HLA)-matched sibling donor (MSD) or an HLA-matched unrelated donor (MUD) available for transplant. Haploidentical donors (HAPLO) have been used for transplantation with safe and comparable outcome to matched donor HCT. Haploidentical HCT (HaploHCT) has extended availability of transplant to patients with lower chances of finding matched donor including minorities. Further optimization is needed to improve upon potential risks of relapse. In this chapter, we review the use of total marrow and lymphoid irradiation (TMLI) in the setting of HaploHCT.

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Authors and Affiliations

  1. Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA, USA

    Shukaib Arslan & Monzr M. AlMalki

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  1. Shukaib Arslan
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  2. Monzr M. AlMalki
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Correspondence to Monzr M. AlMalki .

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Editors and Affiliations

  1. Department of Radiation Oncology, City Of Hope National Medical Center, Duarte, CA, USA

    Jeffrey Y. C. Wong

  2. Department of Radiation Oncology, City Of Hope National Medical Center, Duarte, CA, USA

    Susanta K. Hui

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Arslan, S., AlMalki, M.M. (2020). Total Marrow and Lymphoid Irradiation in Haploidentical Hematopoietic Cell Transplant. In: Wong, J., Hui, S. (eds) Total Marrow Irradiation. Springer, Cham. https://doi.org/10.1007/978-3-030-38692-4_8

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  • DOI: https://doi.org/10.1007/978-3-030-38692-4_8

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-38691-7

  • Online ISBN: 978-3-030-38692-4

  • eBook Packages: MedicineMedicine (R0)

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