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Splenic Marginal Zone Lymphoma and Other Small B-Cell Lymphomas

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Diagnostic Pathology of Hematopoietic Disorders of Spleen and Liver

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Abstract

Most splenic small B-cell lymphomas represent secondary involvement by systemic lymphomas. Primary splenic small B-cell lymphoma is rare. Splenic marginal zone lymphoma (SMZL) is primarily located in the spleen and invariably involves the bone marrow. SMZL in the spleen is characterized by white pulp expansion with lymphoid nodules showing a biphasic pattern, red pulp infiltrate, and intrasinusoidal/intravascular infiltrate in the bone marrow. The other small B-cell lymphomas in the spleen show similar morphologic and phenotypic features of nodal/systemic diseases. The diagnosis of these small B-cell lymphomas is based on integration of clinical presentation, morphology, immunophenotype and genetic findings.

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  1. Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA

    Haipeng Shao

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    Haipeng Shao

  3. Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, CA, USA

    Serhan Alkan

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Shao, H. (2020). Splenic Marginal Zone Lymphoma and Other Small B-Cell Lymphomas. In: Zhang, L., Shao, H., Alkan, S. (eds) Diagnostic Pathology of Hematopoietic Disorders of Spleen and Liver. Springer, Cham. https://doi.org/10.1007/978-3-030-37708-3_5

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