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Oligodendrocyte Progenitor Cells in the Tumor Microenvironment

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Tumor Microenvironment

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1234))

Abstract

Glioblastoma (GBM) develops from adult brain white matter and is the most common and lethal primary brain tumor, characterized by rapid growth and invasion. GBM tumors frequently spread into the contralateral hemisphere, including in the beginning of tumor development. However, after complete resection of the tumor mass and chemo-radiotherapy, GBM commonly recurs around the tumor removal site, suggesting that the microenvironment at the tumor border provides therapeutic resistance to GBM cells. To improve patient prognosis, understanding the microenvironment at the tumor border is critical. Several microRNAs (miRNAs) show higher expression at the tumor border, with the top three involved in oligodendrocyte differentiation. Oligodendrocyte progenitor cells (OPCs) may induce stemness and chemo-radioresistance in GBM cells, providing a supportive function to promote GBM. This review describes important features of OPCs and insights into the “border niche,” a unique microenvironment that allows GBM cells to survive and recur at the tumor border.

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Authors and Affiliations

  1. Department of Neurosurgery, Kitasato University School of Medicine, Kanagawa, Japan

    Takuichiro Hide

  2. Department of Cell Pathology, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan

    Yoshihiro Komohara

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  1. Takuichiro Hide
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Correspondence to Takuichiro Hide .

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  1. Department of Radiology, Columbia University Medical Center, New York, NY, USA, Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Alexander Birbrair

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Hide, T., Komohara, Y. (2020). Oligodendrocyte Progenitor Cells in the Tumor Microenvironment. In: Birbrair, A. (eds) Tumor Microenvironment. Advances in Experimental Medicine and Biology, vol 1234. Springer, Cham. https://doi.org/10.1007/978-3-030-37184-5_8

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