Abstract
The examination of eye movements, and in particular the examination of saccades, is a critical part of the movement disorders examination. Saccadic slowing may be the first sign of an atypical parkinsonian state or of Huntington’s disease, and other eye movement disorders such as ocular flutter or opsoclonus may affect management acutely.
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References
Termsarasab P, Thammongkolchai T, Rucker JC, Frucht SJ. The diagnostic value of saccades in movement disorder patients: a practical guide and review. J Clin Mov Disord. 2015;2:14. https://doi.org/10.1186/s40734-015-0025-4.
Patel SS, Jankovic J, Hood AJ, Jeter CB, Sereno AB. Reflexive and volitional saccades: biomarkers of Huntington disease severity and progression. J Neurol Sci. 2012;313(1–2):35–41. https://doi.org/10.1016/j.jns.2011.09.035.
Leigh RJ, Zee DS. The neurology of eye movements. 5th ed. New York: Oxford University Press; 2015.
Aicardi J, Barbosa C, Andermann E, Andermann F, Morcos R, Ghanem Q, et al. Ataxia-ocular motor apraxia: a syndrome mimicking ataxia-telangiectasia. Ann Neurol. 1988;24(4):497–502. https://doi.org/10.1002/ana.410240404.
Gascon GG, Abdo N, Sigut D, Hemidan A, Hannan MA. Ataxia-oculomotor apraxia syndrome. J Child Neurol. 1995;10(2):118–22.
Criscuolo C, Chessa L, Di Giandomenico S, Mancini P, Sacca F, Grieco GS, et al. Ataxia with oculomotor apraxia type 2: a clinical, pathologic, and genetic study. Neurology. 2006;66(8):1207–10. https://doi.org/10.1212/01.wnl.0000208402.10512.4a.
Le Ber I, Moreira MC, Rivaud-Pechoux S, Chamayou C, Ochsner F, Kuntzer T, et al. Cerebellar ataxia with oculomotor apraxia type 1: clinical and genetic studies. Brain. 2003;126(Pt 12):2761–72. https://doi.org/10.1093/brain/awg283.
Pearson TS. More than Ataxia: hyperkinetic movement disorders in childhood autosomal recessive Ataxia syndromes. Tremor Other Hyperkinet Mov (N Y). 2016;6:368. https://doi.org/10.7916/D8H70FSS.
Steele JC, Richardson JC, Olszewski J. Progressive supranuclear palsy. A heterogeneous degeneration involving the brain stem, basal ganglia and cerebellum with vertical gaze and pseudobulbar palsy, nuchal dystonia and dementia. Arch Neurol. 1964;10:333–59. https://doi.org/10.1001/archneur.1964.00460160003001.
Bhidayasiri R, Riley DE, Somers JT, Lerner AJ, Buttner-Ennever JA, Leigh RJ. Pathophysiology of slow vertical saccades in progressive supranuclear palsy. Neurology. 2001;57(11):2070–7.
Shiozawa M, Fukutani Y, Sasaki K, Isaki K, Hamano T, Hirayama M, et al. Corticobasal degeneration: an autopsy case clinically diagnosed as progressive supranuclear palsy. Clin Neuropathol. 2000;19(4):192–9.
Rusina R, Kovacs GG, Fiala J, Hort J, Ridzon P, Holmerova I, et al. FTLD-TDP with motor neuron disease, visuospatial impairment and a progressive supranuclear palsy-like syndrome: broadening the clinical phenotype of TDP-43 proteinopathies. A report of three cases. BMC Neurol. 2011;11:50. https://doi.org/10.1186/1471-2377-11-50.
Huber FM, Bour F, Sazdovitch V, Hauw JJ, Heinemann U, Zanini F et al. Creutzfeldt-Jakob disease with slow progression. A mimickry of progressive supranuclear palsy. Bulletin de la Societe des sciences medicales du Grand-Duche de Luxembourg. 2007(2):125–30.
Petrovic IN, Martin-Bastida A, Massey L, Ling H, O’Sullivan SS, Williams DR, et al. MM2 subtype of sporadic Creutzfeldt-Jakob disease may underlie the clinical presentation of progressive supranuclear palsy. J Neurol. 2013;260(4):1031–6. https://doi.org/10.1007/s00415-012-6752-7.
Prasad S, Ko MW, Lee EB, Gonatas NK, Stern MB, Galetta S. Supranuclear vertical gaze abnormalities in sporadic Creutzfeldt-Jakob disease. J Neurol Sci. 2007;253(1–2):69–72. https://doi.org/10.1016/j.jns.2006.11.010.
Di Fonzo A, Chien HF, Socal M, Giraudo S, Tassorelli C, Iliceto G, et al. ATP13A2 missense mutations in juvenile parkinsonism and young onset Parkinson disease. Neurology. 2007;68(19):1557–62. https://doi.org/10.1212/01.wnl.0000260963.08711.08.
Newsway V, Fish M, Rohrer JD, Majounie E, Williams N, Hack M, et al. Perry syndrome due to the DCTN1 G71R mutation: a distinctive levodopa responsive disorder with behavioral syndrome, vertical gaze palsy, and respiratory failure. Mov Disord. 2010;25(6):767–70. https://doi.org/10.1002/mds.22950.
Fenollar F, Puechal X, Raoult D. Whipple’s disease. N Engl J Med. 2007;356(1):55–66. https://doi.org/10.1056/NEJMra062477.
Salsano E, Umeh C, Rufa A, Pareyson D, Zee DS. Vertical supranuclear gaze palsy in Niemann-Pick type C disease. Neurol Sci. 2012;33(6):1225–32. https://doi.org/10.1007/s10072-012-1155-1.
Wadia NH, Swami RK. A new form of heredo-familial spinocerebellar degeneration with slow eye movements (nine families). Brain. 1971;94(2):359–74.
Benko W, Ries M, Wiggs EA, Brady RO, Schiffmann R, Fitzgibbon EJ. The saccadic and neurological deficits in type 3 Gaucher disease. PLoS One. 2011;6(7):e22410. https://doi.org/10.1371/journal.pone.0022410.
Quinn N. The “round the houses” sign in progressive supranuclear palsy. Ann Neurol. 1996;40(6):951. https://doi.org/10.1002/ana.410400630.
Briand KA, Strallow D, Hening W, Poizner H, Sereno AB. Control of voluntary and reflexive saccades in Parkinson’s disease. Exp Brain Res. 1999;129(1):38–48.
Rottach KG, Riley DE, DiScenna AO, Zivotofsky AZ, Leigh RJ. Dynamic properties of horizontal and vertical eye movements in parkinsonian syndromes. Ann Neurol. 1996;39(3):368–77. https://doi.org/10.1002/ana.410390314.
White OB, Saint-Cyr JA, Tomlinson RD, Sharpe JA. Ocular motor deficits in Parkinson’s disease. II. Control of the saccadic and smooth pursuit systems. Brain. 1983;106(Pt 3):571–87.
Anderson T, Luxon L, Quinn N, Daniel S, Marsden CD, Bronstein A. Oculomotor function in multiple system atrophy: clinical and laboratory features in 30 patients. Mov Disord. 2008;23(7):977–84. https://doi.org/10.1002/mds.21999.
Hasegawa S, Matsushige T, Kajimoto M, Inoue H, Momonaka H, Oka M, et al. A nationwide survey of opsoclonus-myoclonus syndrome in Japanese children. Brain Dev. 2014;37:656. https://doi.org/10.1016/j.braindev.2014.10.010.
Morita A, Ishihara M, Kamei S, Ishikawa H. Opsoclonus-myoclonus syndrome following influenza a infection. Intern Med. 2012;51(17):2429–31.
Sheth RD, Horwitz SJ, Aronoff S, Gingold M, Bodensteiner JB. Opsoclonus myoclonus syndrome secondary to Epstein-Barr virus infection. J Child Neurol. 1995;10(4):297–9.
Brissaud HE, Beauvais P. Opsoclonus and neuroblastoma. N Engl J Med. 1969;280(22):1242.
Laroumagne S, Elharrar X, Coiffard B, Plojoux J, Dutau H, Breen D, et al. “Dancing eye syndrome” secondary to opsoclonus-myoclonus syndrome in small-cell lung cancer. Case Rep Med. 2014;2014:545490. https://doi.org/10.1155/2014/545490.
Rossor AM, Perry F, Botha A, Norwood F. Opsoclonus myoclonus syndrome due to squamous cell carcinoma of the oesophagus. BMJ Case Rep. 2014;2014 https://doi.org/10.1136/bcr-2013-202849.
Sandok BA, Kranz H. Opsoclonus as the initial manifestation of occult neuroblastoma. Arch Ophthalmol. 1971;86(2):235–6.
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This Chapter reviews the important role that eye movements play in the evaluation of the movement disorders patient. The video is divided into eight segments: saccades in PSP; asaccadia after aortic aneurysm repair; saccades in HD; saccades in choreic neurodegenerative disorders; eye movements in multiple system atrophy; macrosaccadic oscillations in Friedreich’s ataxia; eye movement abnormalities in genetic ataxias; and assorted saccadic disorders (MP4 1913752 kb)
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Frucht, S.J., Termsarasab, P. (2020). “The Eyes Have It”: Saccades and Fixation Defects in Movement Disorders. In: Movement Disorders Phenomenology. Springer, Cham. https://doi.org/10.1007/978-3-030-36975-0_12
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DOI: https://doi.org/10.1007/978-3-030-36975-0_12
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