Abstract
In this chapter, we will present monocytes and macrophages as the key players in acute and chronic inflammation. Macrophages react stimulus- and tissue-specifically and either develop from monocytes that are circulating in the blood or from self-renewing embryonal cell populations. M1-type macrophages are key cells in the initiation of the acute inflammatory response, while M2-type macrophages are resolving inflammation and coordinate tissue repair. Tissue inflammation is not only caused by bacterial infection or tissue injury but also derives from changes in the concentration of nutrients and metabolites. We will provide examples of metabolic stress, such as disturbance of reverse cholesterol transport and ER stress. The latter is, in contrast to infectious or traumatic stress, often caused by lipid overload in the blood and in adipose tissue. Thus, the immune system is implicated in the regulation of metabolic homeostasis, while perturbations in this immune-metabolic network are often the basis of the different features of the metabolic syndrome.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Additional Readings
Franceschi C, Garagnani P, Parini P, Giuliani C, Santoro A (2018) Inflammaging: a new immune-metabolic viewpoint for age-related diseases. Nat Rev. Endocrinol 14:576–590
Galluzzi L, Yamazaki T, Kroemer G (2018) Linking cellular stress responses to systemic homeostasis. Nat Rev. Mol Cell Biol 19:731–745
Tall AR, Yvan-Charvet L (2015) Cholesterol, inflammation and innate immunity. Nat Rev. Immunol 15:104–116
Wang A, Luan HH, Medzhitov R (2019) An evolutionary perspective on immunometabolism. Science 363
Zmora N, Bashiardes S, Levy M, Elinav E (2017) The role of the immune system in metabolic health and disease. Cell Metab 25:506–521
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Carlberg, C., Ulven, S.M., Molnár, F. (2020). Chronic Inflammation and Metabolic Stress. In: Nutrigenomics: How Science Works. Springer, Cham. https://doi.org/10.1007/978-3-030-36948-4_7
Download citation
DOI: https://doi.org/10.1007/978-3-030-36948-4_7
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-36947-7
Online ISBN: 978-3-030-36948-4
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)