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Thyroid and Cardiovascular Risk

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Thyroid and Heart

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Abstract

Here we present data on the clinical effects of abnormalities in thyroid hormone levels on cardiovascular risk, focusing on the risks associated with subclinical thyroid dysfunction. Some observational studies and randomized clinical trials have suggested that subclinical hypothyroidism causes reversible alterations in surrogate markers of cardiovascular disease such as lipid levels and carotid intima media thickness. RCTs and meta-analyses to date have not shown effects of levothyroxine treatment for patients with subclinical hypothyroidism on clinical and cardiovascular outcomes, but were underpowered to detect effects on cardiac events and mortality. Observational data strongly support the treatment of subclinical hyperthyroidism to prevent atrial fibrillation and heart failure, but the degree to which the cardiovascular risk is reversible is unknown since prospective, randomized controlled trials of treatment of subclinical hyperthyroidism are not available.

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Authors and Affiliations

  1. Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, The Netherlands

    Wendy P. J. den Elzen & Bart E. P. B. Ballieux

  2. Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands

    Simon P. Mooijaart & Jacobijn Gussekloo

  3. The Institute for Evidence-based Medicine in Old Age, Leiden, The Netherlands

    Simon P. Mooijaart

  4. Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA

    Anne R. Cappola

  5. Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands

    Jacobijn Gussekloo

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  1. Wendy P. J. den Elzen
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  3. Bart E. P. B. Ballieux
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  4. Anne R. Cappola
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  5. Jacobijn Gussekloo
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Correspondence to Wendy P. J. den Elzen .

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Editors and Affiliations

  1. Institute of Clinical Physiology (IFC) National Research Council (CNR), Pisa, Italy

    Giorgio Iervasi

  2. Institute of Clinical Physiology (IFC) National Research Council (CNR), Pisa, Italy

    Alessandro Pingitore

  3. NYITCOM College of Osteopathic Medicine Biomedical Sciences Department, Old Westbury, NY, USA

    A.Martin Gerdes

  4. Institute of Clinical and Translational Medicine, Newcastle University/Queen Elizabeth Hospital, Newcastle upon Tyne, UK

    Salman Razvi

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den Elzen, W.P.J., Mooijaart, S.P., Ballieux, B.E.P.B., Cappola, A.R., Gussekloo, J. (2020). Thyroid and Cardiovascular Risk. In: Iervasi, G., Pingitore, A., Gerdes, A., Razvi, S. (eds) Thyroid and Heart . Springer, Cham. https://doi.org/10.1007/978-3-030-36871-5_16

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