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Therapeutic Hypothermia in Neurocritical Care

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Neurointensive Care Unit

Part of the book series: Current Clinical Neurology ((CCNEU))

Abstract

The neuroprotective benefits of therapeutic hypothermia (TH) have been known for several decades but have become conventional in clinical practice only over the last decade, after large randomized clinical trials (RCT) affirmed the benefits of TH in preventing neurologic injury, predominantly in cardiac arrest survivors. In neurocritical care, the applications of TH have been extended to several critical neurologic illnesses including refractory elevation in intracranial pressure (ICP), status epilepticus, ischemic stroke, and traumatic brain injury among others. The appropriate clinical use of TH requires understanding the postulated pathophysiologic mechanisms behind TH-induced neuroprotection, associated wanted and unwanted physiologic effects of TH, methods of inducing TH, and clinical care of patients during TH. All of these aspects will be addressed in this chapter.

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Authors and Affiliations

  1. Department of Neurology and Neurosurgery, University of Arkansas for Medical Sciences, Little Rock, AR, USA

    Vishank Arun Shah

  2. Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Romergryko G. Geocadin

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  1. Vishank Arun Shah
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  2. Romergryko G. Geocadin
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Correspondence to Vishank Arun Shah .

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  1. Johns Hopkins University, Baltimore, MD, USA

    Sarah E. Nelson

  2. Johns Hopkins University, Baltimore, MD, USA

    Paul A. Nyquist

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Shah, V.A., Geocadin, R.G. (2020). Therapeutic Hypothermia in Neurocritical Care. In: Nelson, S., Nyquist, P. (eds) Neurointensive Care Unit. Current Clinical Neurology. Humana, Cham. https://doi.org/10.1007/978-3-030-36548-6_5

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  • DOI: https://doi.org/10.1007/978-3-030-36548-6_5

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