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Cancer Stem Cell Niche and Immune-Active Tumor Microenvironment in Testicular Germ Cell Tumors

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Tumor Microenvironments in Organs

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1226))

Abstract

Testicular germ cell tumors (TGCTs) represent the most common neoplasia among young men. Management of TGCTs is an excellent example of curative outcomes in clinical oncology. The unique sensitivity to cisplatin-based chemotherapy regimens has led to establishing TGCTs as a “model of cancer cure.” However, mechanisms and factors underlying pervasive growth of TGCTs are still poorly understood. It is suggested that unique cancer stem cell (CSC) niche exists in the testicular tumor microenvironment. CSC niche potentially contributes to the progression of germ cell tumors. Furthermore, rich infiltration of TGCTs with immune cells indicates involvement of immune system in biology of this cancer type. This review summarizes current knowledge regarding specific cancer microenvironment in TGCTs and discusses the role of cancer stem cells as well as immune mechanisms in these tumors.

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Authors and Affiliations

  1. Translational Research Unit, Faculty of Medicine, Comenius University and National Cancer Institute, Bratislava, Slovakia

    Katarina Kalavska & Michal Mego

  2. Department of Molecular Oncology, Cancer Research Institute, Biomedical Research Center, University Science Park for Biomedicine, Slovak Academy of Sciences, Bratislava, Slovakia

    Katarina Kalavska, Lucia Kucerova, Silvia Schmidtova & Michal Mego

  3. Faculty of Medicine, 2nd Department of Oncology, Comenius University and National Cancer Institute, Bratislava, Slovakia

    Michal Chovanec & Michal Mego

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  1. Katarina Kalavska
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  2. Lucia Kucerova
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  3. Silvia Schmidtova
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  4. Michal Chovanec
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  5. Michal Mego
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  1. Columbia University Medical Center, Department of Radiology, New York, NY, USA, Federal University of Minas Gerais, Department of Pathology, Belo Horizonte, Minas Gerais, Brazil

    Alexander Birbrair

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Kalavska, K., Kucerova, L., Schmidtova, S., Chovanec, M., Mego, M. (2020). Cancer Stem Cell Niche and Immune-Active Tumor Microenvironment in Testicular Germ Cell Tumors. In: Birbrair, A. (eds) Tumor Microenvironments in Organs. Advances in Experimental Medicine and Biology, vol 1226. Springer, Cham. https://doi.org/10.1007/978-3-030-36214-0_9

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