Abstract
This chapter concludes the book with a discussion of current and future directions in research and their potential to guide innovation in prevention and treatment of self-injury. We focus on three areas of potential promise. The first is primary and secondary prevention of the development and maintenance of chronic self-injurious behavior by early intervention in childhood. The second is identification of cross-syndrome processes in the neurobiology of genetic syndromes associated with self-injury. Particular emphasis is placed on impairments in inhibitory processes, with research examining both functional connectivity in relevant networks and synaptic development and functioning in inhibitory cortical and hippocampal interneurons. The third is the potential for basic and translational research in learning processes to increase the effectiveness and robustness of behavioral interventions, with particular emphasis on the utility of behavioral momentum theory in understanding the basic behavioral processes, including behavioral reinstatement, renewal, and resurgence, which underlie relapse following successful intervention.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Arron, K., Oliver, C., Moss, J., Berg, K., & Burbidge, C. (2011). The prevalence and phenomenology of self-injurious and aggressive behaviour in genetic syndromes. Journal of Intellectual Disability Research, 55(2), 109–120. https://doi.org/10.1111/j.1365-2788.2010.01337
Baghdadli, A., Picot, M. C., Pry, R., Michelon, C., Burzstejn, C., Lazartigues, A., & Aussilloux, C. (2008). What factors are related to a negative outcome of self-injurious behaviour during childhood in pervasive developmental disorders? Journal of Applied Research in Intellectual Disabilities, 21(2), 142–149. https://doi.org/10.1111/j.1468-3148.2007.00389.x
Benke, D., & Möhler, H. (2018). Impact on GABA systems in monogenetic developmental CNS disorders: Clues to symptomatic treatment. Neuropharmacology, 136(Part A), 46–55. https://doi.org/10.1016/j.neuropharm.2017.07.030
Berg, K. L., Shiu, C. S., Acharya, K., Stolbach, B. C., & Msall, M. E. (2016). Disparities in adversity among children with autism spectrum disorder: A population-based study. Developmental Medicine and Child Neurology, 58(11), 1124–1131. https://doi.org/10.1111/dmcn.13161
Bernal-Gamboa, R., Nieto, J., & Uengoer, M. (2017). Effects of extinction in multiple contexts on renewal of instrumental responses. Behavioural Processes, 142, 64–69. https://doi.org/10.1016/j.beproc.2017.06.003
Bouton, M. E. (2019). Extinction of instrumental (operant) learning: Interference, varieties of context, and mechanisms of contextual control. Psychopharmacology, 236(1), 7–19. https://doi.org/10.1007/s00213-018-5076-4
Braat, S., & Kooy, R. F. (2015). The GABAA receptor as a therapeutic target for neurodevelopmental disorders. Neuron, 86(5), 1119–1130. https://doi.org/10.1016/j.neuron.2015.03.042
Brondino, N., Fusar-Poli, L., Panisi, C., Damiani, S., Barale, F., & Politi, P. (2016). Pharmacological modulation of GABA function in autism spectrum disorders: A systematic review of human studies. Journal of Autism and Developmental Disorders, 46(3), 825–839. https://doi.org/10.1007/s10803-015-2619-y
Browning, K. O., & Shahan, T. A. (2018). Renewal of extinguished operant behavior following changes in social context. Journal of the Experimental Analysis of Behavior, 110(3), 430–439. https://doi.org/10.1002/jeab.472
Chadwick, O., Kusel, Y., & Cuddy, M. (2008). Factors associated with the risk of behaviour problems in adolescents with severe intellectual disabilities. Journal of Intellectual Disability Research, 52(10), 864–876. https://doi.org/10.1111/j.1365-2788.2008.01102.x
Chaney, S. (2013). Self-mutilation and psychiatry: Impulse, identity and the unconscious in British explanations of self-inflicted injury, c. 1864 – 1914 (Ph.D. thesis). London: University College London. Retrieved from http://discovery.ucl.ac.uk/view/theses/UCL_Thesis/
Chao, H. T., Chen, H., Samaco, R. C., Xue, M., Chahrour, M., Yoo, J., … Zoghbi, H. Y. (2010). Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes. Nature, 468(7321), 263–269. https://doi.org/10.1038/nature09582
Cohenour, J. M., Volkert, V. M., & Allen, K. D. (2018). An experimental demonstration of AAB renewal in children with autism spectrum disorder. Journal of the Experimental Analysis of Behavior, 110(1), 63–73. https://doi.org/10.1002/jeab.443
Collacott, R. A., Cooper, S.-A., Branford, D., & McGrother, C. (1998). Epidemiology of self-injurious behaviour in adults with learning disabilities. British Journal of Psychiatry, 173(5), 428–432. https://doi.org/10.1192/bjp.173.5.428
Cooper, S.-A., Smiley, E., Allan, L. M., Jackson, A., Finlayson, J., Mantry, D., & Morrison, J. (2009). Adults with intellectual disabilities: Prevalence, incidence and remission of self-injurious behaviour, and related factors. Journal of Intellectual Disability Research, 53(3), 200–216. https://doi.org/10.1111/j.1365-2788.2008.01060.x
Craig, A. R., Cunningham, P. J., Sweeney, M. M., Shahan, T. A., & Nevin, J. A. (2018). Delivering alternative reinforcement in a distinct context reduces its counter-therapeutic effects on relapse. Journal of the Experimental Analysis of Behavior, 109(3), 492–505. https://doi.org/10.1002/jeab.431
Cuthbert, B. N. (2015). Research domain criteria: Toward future psychiatric nosologies. Dialogues in Clinical Neuroscience, 17(1), 89–97. Retrieved from https://www.dialogues-cns.org/contents17-1/
Cuthbert, B. N. (2019). The PRISM project: Social withdrawal from an RDoC perspective. Neuroscience and Biobehavioral Reviews, 97, 34–37. https://doi.org/10.1016/j.neubiorev.2018.08.006
Davies, L. E., & Oliver, C. (2016). Self-injury, aggression and destruction in children with severe intellectual disability: Incidence, persistence and novel, predictive behavioural risk markers. Research in Developmental Disabilities, 49–50, 291–301. https://doi.org/10.1016/j.ridd.2015.12.003
DeLeon, I. G., Gregory, M. K., & St. Peter, C. C. (2013). Recent developments in behavioral intervention informed by basic research. International Review of Research in Developmental Disabilities, 44, 213–244. https://doi.org/10.1016/B978-0-12-401662-0.00007-5
Dimian, A. F., Botteron, K. N., Dager, S. R., Elison, J. T., Estes, A. M., Pruett, J. R., … Wolff, J. J. (2017). Potential risk factors for the development of self-injurious behavior among infants at risk for autism spectrum disorder. Journal of Autism and Developmental Disorders, 47(5), 1403–1415. https://doi.org/10.1007/s10803-017-3057-9
Fisher, W. W., Greer, B. D., Craig, A. R., Retzlaff, B. J., Fuhrman, A. M., Lichtblau, K. R., & Saini, V. (2018). On the predictive validity of behavioral momentum theory for mitigating resurgence of problem behavior. Journal of the Experimental Analysis of Behavior, 109(1), 281–290. https://doi.org/10.1002/jeab.303
Fisher, W. W., Saini, V., Greer, B. D., Sullivan, W. E., Roane, H. S., Fuhrman, A. M., … Kimball, R. T. (2019). Baseline reinforcement rate and resurgence of destructive behavior. Journal of the Experimental Analysis of Behavior, 111(1), 75–93. https://doi.org/10.1002/jeab.488
Fodstad, J. C., Kirsch, A., Faidley, M., & Bauer, N. (2018). Demonstration of parent training to address early self-injury in young children with intellectual and developmental delays. Journal of Autism and Developmental Disorders, 48(11), 3846–3857. https://doi.org/10.1007/s10803-018-3651-5
Golden, C. E., Buxbaum, J. D., & De Rubeis, S. (2018). Disrupted circuits in mouse models of autism spectrum disorder and intellectual disability. Current Opinion in Neurobiology, 48, 106–112. https://doi.org/10.1016/j.conb.2017.11.006
Greer, B. D., & Shahan, T. A. (2019). Resurgence as choice: Implications for promoting durable behavior change. Journal of Applied Behavior Analysis, 52(3), 816–846. https://doi.org/10.1002/jaba.573
Hanley, G. P., Jin, C. S., Vanselow, N. R., & Hanratty, L. A. (2014). Producing meaningful improvements in problem behavior of children with autism via synthesized analyses and treatments. Journal of Applied Behavior Analysis, 47(1), 16–36. https://doi.org/10.1002/jaba.106
Ito-Ishida, A., Ure, K., Chen, H., Swann, J. W., & Zoghbi, H. Y. (2015). Loss of MeCP2 in parvalbumin-and somatostatin-expressing neurons in mice leads to distinct Rett syndrome-like phenotypes. Neuron, 88(4), 651–658. https://doi.org/10.1016/j.neuron.2015.10.029
Jessel, J., Hanley, G. P., Ghaemmaghami, M., & Metras, R. (2019). An evaluation of the single-session interview-informed synthesized contingency analysis. Behavioral Interventions, 34(1), 62–78. https://doi.org/10.1002/bin.1650
Jessel, J., Ingvarsson, E. T., Metras, R., Kirk, H., & Whipple, R. (2018). Achieving socially significant reductions in problem behavior following the interview-informed synthesized contingency analysis: A summary of 25 outpatient applications. Journal of Applied Behavior Analysis, 51(1), 130–157. https://doi.org/10.1002/jaba.436
Kas, M. J., Penninx, B., Sommer, B., Serretti, A., Arango, C., & Marston, H. (2019). A quantitative approach to neuropsychiatry: The why and the how. Neuroscience and Biobehavioral Reviews, 97, 3–9. https://doi.org/10.1016/j.neubiorev.2017.12.008
Katz, D. M., Bird, A., Coenraads, M., Gray, S. J., Menon, D. U., Philpot, B. D., & Tarquinio, D. C. (2016). Rett syndrome: Crossing the threshold to clinical translation. Trends in Neurosciences, 39(2), 100–113. https://doi.org/10.1016/j.tins.2015.12.008
Krisch, K. A., Bandarian-Balooch, S., & Neumann, D. L. (2018). Effects of extended extinction and multiple extinction contexts on ABA renewal. Learning and Motivation, 63, 1–10. https://doi.org/10.1016/j.lmot.2017.11.001
Kuroda, T., Mizutani, Y., Cançado, C. R. X., & Podlesnik, C. A. (2017). Operant models of relapse in zebrafish (Danio rerio): Resurgence, renewal, and reinstatement. Behavioural Brain Research, 335, 215–222. https://doi.org/10.1016/j.bbr.2017.08.023
Liggett, A. P., Nastri, R., & Podlesnik, C. A. (2018). Assessing the combined effects of resurgence and reinstatement in children diagnosed with autism spectrum disorder. Journal of the Experimental Analysis of Behavior, 109(2), 408–421. https://doi.org/10.1002/jeab.315
Ligsay, A., Van Dijck, A., Nguyen, D. V., Lozano, R., Chen, Y., Bickel, E. S., … Hagerman, R. J. (2017). A randomized double-blind, placebo-controlled trial of ganaxolone in children and adolescents with fragile X syndrome. Journal of Neurodevelopmental Disorders, 9(1). https://doi.org/10.1186/s11689-017-9207-8
Lucyshyn, J. M., Fossett, B., Bakeman, R., Cheremshynski, C., Miller, L., Lohrmann, S., … Irvin, L. K. (2015). Transforming Parent–Child interaction in family routines: Longitudinal analysis with families of children with developmental disabilities. Journal of Child and Family Studies, 24(12), 3526–3541. https://doi.org/10.1007/s10826-015-0154-2
Lucyshyn, J. M., Miller, L. D., Cheremshynski, C., Lohrmann, S., & Zumbo, B. D. (2018). Transforming coercive processes in family routines: Family functioning outcomes for families of children with developmental disabilities. Journal of Child and Family Studies, 27(9), 2844–2861. https://doi.org/10.1007/s10826-018-1113-5
McKinnon, C. J., Eggebrecht, A. T., Todorov, A., Wolff, J. J., Elison, J. T., Adams, C. M., … Pruett, J. R. (2019). Restricted and repetitive behavior and brain functional connectivity in infants at risk for developing autism spectrum disorder. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 4(1), 50–61. https://doi.org/10.1016/j.bpsc.2018.09.008
Midouhas, E., Yogaratnam, A., Flouri, E., & Charman, T. (2013). Psychopathology trajectories of children with autism spectrum disorder: The role of family poverty and parenting. Journal of the American Academy of Child and Adolescent Psychiatry, 52(10), 1057–1065.e1. https://doi.org/10.1016/j.jaac.2013.07.011
Minshawi, N. F., Hurwitz, S., Morriss, D., & McDougle, C. J. (2015). Multidisciplinary assessment and treatment of self-injurious behavior in autism spectrum disorder and intellectual disability: Integration of psychological and biological theory and approach. Journal of Autism and Developmental Disorders, 45(6), 1541–1568. https://doi.org/10.1007/s10803-014-2307-3
Nevin, J. A., Craig, A. R., Cunningham, P. J., Podlesnik, C. A., Shahan, T. A., & Sweeney, M. M. (2017). Quantitative models of persistence and relapse from the perspective of behavioral momentum theory: Fits and misfits. Behavioural Processes, 141(Part 1), 92–99. https://doi.org/10.1016/j.beproc.2017.04.016
Nutt, D., Robbins, T., & Hayes, A. (2018). THuNDRous news for human dopamine researchers: A selective dopamine D1 receptor antagonist will soon be available for clinical research. Journal of Psychopharmacology, 32(11), 1153–1154. https://doi.org/10.1177/0269881118799380
Olatunji, B. O., Tomarken, A., Wentworth, B., & Fritzsche, L. (2017). Effects of exposure in single and multiple contexts on fear renewal: The moderating role of threat-specific and nonspecific emotionality. Journal of Behavior Therapy and Experimental Psychiatry, 54, 270–277. https://doi.org/10.1016/j.jbtep.2016.09.004
Oliver, C., Licence, L., & Richards, C. (2017). Self-injurious behaviour in people with intellectual disability and autism spectrum disorder. Current Opinion in Psychiatry, 30(2), 97–101. https://doi.org/10.1097/YCO.0000000000000313
Pijl, M. K. J., Bussu, G., Charman, T., Johnson, M. H., Jones, E. J. H., Pasco, G., … Buitelaar, J. K. (2019). Temperament as an early risk marker for autism spectrum disorders? A longitudinal study of high-risk and low-risk infants. Journal of Autism and Developmental Disorders, 49(5), 1825–1836. https://doi.org/10.1007/s10803-018-3855-8
Podlesnik, C. A., Kuroda, T., Jimenez-Gomez, C., Abreu-Rodrigues, J., Cançado, C. R. X., Blackman, A. L., … Teixeira, I. S. C. (2019). Resurgence is greater following a return to the training context than remaining in the extinction context. Journal of the Experimental Analysis of Behavior, 111(3), 416–435. https://doi.org/10.1002/jeab.505
Podlesnik, C. A., & Shahan, T. A. (2009). Behavioral momentum and relapse of extinguished operant responding. Learning and Behavior, 37(4), 357–364. https://doi.org/10.3758/LB.37.4.357
Rattaz, C., Michelon, C., & Baghdadli, A. (2015). Symptom severity as a risk factor for self-injurious behaviours in adolescents with autism spectrum disorders. Journal of Intellectual Disability Research, 59(8), 730–740. https://doi.org/10.1111/jir.12177
Richman, D. M., Barnard-Brak, L., Bosch, A., Thompson, S., Grubb, L., & Abby, L. (2013). Predictors of self-injurious behaviour exhibited by individuals with autism spectrum disorder. Journal of Intellectual Disability Research, 57(5), 429–439. https://doi.org/10.1111/j.1365-2788.2012.01628.x
Rodriguez, R. A., Joya, C., & Hines, R. M. (2018). Common ribs of inhibitory synaptic dysfunction in the umbrella of neurodevelopmental disorders. Frontiers in Molecular Neuroscience, 11, 132. https://doi.org/10.3389/fnmol.2018.00132
Rojahn, J., Matson, J. L., Naglieri, J. A., & Mayville, E. (2004). Relationships between psychiatric conditions and behavior problems among adults with mental retardation. American Journal on Mental Retardation, 109(1), 21–33 + 77. https://doi.org/10.1352/0895-8017(2004)109<21:RBPCAB>2.0.CO;2
Rubenstein, J. L. R., & Merzenich, M. M. (2003). Model of autism: Increased ratio of excitation/inhibition in key neural systems. Genes, Brain and Behavior, 2(5), 255–267. https://doi.org/10.1034/j.1601-183X.2003.00037.x
Shirley, M. D., Frelin, L., López, J. S., Jedlicka, A., Dziedzic, A., Frank-Crawford, M. A., … Pevsner, J. (2016). Copy number variants associated with 14 cases of self-injurious behavior. PLoS One, 11(3), e0149646. https://doi.org/10.1371/journal.pone.0149646
Singewald, N., & Holmes, A. (2019). Rodent models of impaired fear extinction. Psychopharmacology, 236(1), 21–32. https://doi.org/10.1007/s00213-018-5054-x
Soke, G. N., Rosenberg, S. A., Hamman, R. F., Fingerlin, T., Rosenberg, C. R., Carpenter, L., … DiGuiseppi, C. (2017). Factors associated with self-injurious behaviors in children with autism spectrum disorder: Findings from two large national samples. Journal of Autism and Developmental Disorders, 47(2), 285–296. https://doi.org/10.1007/s10803-016-2951-x
Soke, G. N., Rosenberg, S. A., Rosenberg, C. R., Vasa, R. A., Lee, L. C., & DiGuiseppi, C. (2018). Self-injurious behaviors in children with autism spectrum disorder enrolled in the study to explore early development. Autism, 22(5), 625–635. https://doi.org/10.1177/1362361316689330
Tsiouris, J. A., Kim, S. Y., Brown, W. T., & Cohen, I. L. (2011). Association of aggressive behaviours with psychiatric disorders, age, sex and degree of intellectual disability: A large-scale survey. Journal of Intellectual Disability Research, 55(7), 636–649. https://doi.org/10.1111/j.1365-2788.2011.01418.x
Voorhies, W., Dajani, D. R., Vij, S. G., Shankar, S., Turan, T. O., & Uddin, L. Q. (2018). Aberrant functional connectivity of inhibitory control networks in children with autism spectrum disorder. Autism Research, 11(11), 1468–1478. https://doi.org/10.1002/aur.2014
Willoughby, M. T., Gottfredson, N. C., & Stifter, C. A. (2017). Observed temperament from ages 6 to 36 months predicts parent- and teacher-reported attention-deficit/hyperactivity disorder symptoms in first grade. Development and Psychopathology, 29(1), 107–120. https://doi.org/10.1017/S0954579415001236
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Furniss, F., Biswas, A.B. (2020). Current Developments and Future Prospects for Prevention and Treatment of Self-Injurious Behavior. In: Self-Injurious Behavior in Individuals with Neurodevelopmental Conditions . Autism and Child Psychopathology Series. Springer, Cham. https://doi.org/10.1007/978-3-030-36016-0_9
Download citation
DOI: https://doi.org/10.1007/978-3-030-36016-0_9
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-36015-3
Online ISBN: 978-3-030-36016-0
eBook Packages: Behavioral Science and PsychologyBehavioral Science and Psychology (R0)