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Engineered Nanomaterial Interaction with Epithelial and Immune Cells upon Mucosal Drug Delivery

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Mucosal Delivery of Drugs and Biologics in Nanoparticles

Part of the book series: AAPS Advances in the Pharmaceutical Sciences Series ((AAPS,volume 41))

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Abstract

The mucosal membranes (i.e. oral, and nasal cavities, gut and female reproductive tract) throughout the body are ideal locations for drug delivery as they result in rapid uptake of the pharmaceutical into the blood system; however, these membranes are protected by the mucosal immune system (MIS). This intricate network of epithelial cells, microbiota, immune cells and mucus present a unique challenge for drug delivery due to their barrier functions and responses to foreign pathogens. There is a constant need to improve drug delivery methods, particularly in regard to mucosal drug delivery. The application of engineered nanomaterials (ENM), due to their unique physicochemical properties, have significant potential to improve mucosal drug delivery. This chapter will discuss key physicochemical properties (i.e. size, shape, surface functionalization, and solubility) and how modification of these properties can alter the biological impact of ENMs. Finally, a brief overview of the normal function of key MIS cells (i.e. epithelial cells, goblet cells, Paneth cells, dendritic cells, macrophages, T and B lymphocytes, mast cells, and endothelial cells) and how ENM exposure alters their function will be presented.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO, USA

    Valerie C. Minarchick & Jared M. Brown

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  1. Valerie C. Minarchick
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  2. Jared M. Brown
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Correspondence to Jared M. Brown .

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Editors and Affiliations

  1. Department of Pharmaceutical Sciences, College Pharmacy, University of New Mexico, Albuquerque, NM, USA

    Pavan Muttil

  2. Department of Pharmaceutical Sciences College of Pharmacy and Health Sciences, St. John’s University, Jamaica, NY, USA

    Nitesh K. Kunda

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Minarchick, V.C., Brown, J.M. (2020). Engineered Nanomaterial Interaction with Epithelial and Immune Cells upon Mucosal Drug Delivery. In: Muttil, P., Kunda, N. (eds) Mucosal Delivery of Drugs and Biologics in Nanoparticles. AAPS Advances in the Pharmaceutical Sciences Series, vol 41. Springer, Cham. https://doi.org/10.1007/978-3-030-35910-2_9

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