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Tumor Microenvironment pp 1–20Cite as

Neutrophils in the Tumor Microenvironment

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1224))

Abstract

Neutrophils are the first responders to inflammation, infection, and injury. As one of the most abundant leukocytes in the immune system, neutrophils play an essential role in cancer progression, through multiple mechanisms, including promoting angiogenesis, immunosuppression, and cancer metastasis. Recent studies demonstrating elevated neutrophil to lymphocyte ratios suggest neutrophil as a potential therapeutic target and biomarker for disease status in cancer. This chapter will discuss the phenotypic and functional changes in the neutrophil in the tumor microenvironment, the underlying mechanism(s) of neutrophil facilitated cancer metastasis, and clinical potential of neutrophils as a prognostic/diagnostic marker and therapeutic target.

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Acknowledgments

This work was supported in part by grants R01CA228524 and Cancer Center Support Grant (P30CA036727) from the National Cancer Institute, National Institutes of Health. Lingyun Wu, as a graduate student, was supported by a scholarship from the Chinese Scholarship Council and a predoctoral fellowship from the University of Nebraska Medical Center. We thank Ms. Alea Hall, UNMC writing center consultant, for the assistance in editing the manuscript.

Conflict of Interest: The authors declare no potential conflicts of interest.

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  1. Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA

    Lingyun Wu, Sugandha Saxena & Rakesh K. Singh

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  1. Lingyun Wu
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Correspondence to Rakesh K. Singh .

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  1. Columbia University Medical Center, Department of Radiology, New York, NY, USA, Federal University of Minas Gerais, Department of Pathology, Belo Horizonte, Minas Gerais, Brazil

    Alexander Birbrair

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Wu, L., Saxena, S., Singh, R.K. (2020). Neutrophils in the Tumor Microenvironment. In: Birbrair, A. (eds) Tumor Microenvironment. Advances in Experimental Medicine and Biology, vol 1224. Springer, Cham. https://doi.org/10.1007/978-3-030-35723-8_1

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