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HIV Infection in Children and Adolescents pp 89–102Cite as

HIV Related CNS Disorders in Children

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Abstract

HIV infection associated central nervous diseases and developmental disabilities in perinatally infected children contribute to a major burden of morbidity and mortality, especially in sub-Sahara Africa. HIV infection associated CNS disease comprises of neurocognitive, motor, behavioural, language and communication impairments. In 2017, only 52% of children aged 0–14 years living with HIV, had access to antiretroviral treatment. The majority of these children with limited access to ART live in sub- Sahara Africa. Where access to ART is available, the number of surviving HIV infected children and adolescents has increased; many of these children and adolescents display HIV associated CNS morbidity.

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References

  1. UNAIDS Data 2018. https://www.unaids.org/en/resources/documents/2018/unaids-data-2018.

  2. Mwaba, et al. The effect of HIV on developmental milestones in children. J AIDS Clin Res. 2016;6(7):1–7.

    Google Scholar 

  3. Lobato MN, et al. Encephalopathy in children with perinatally acquired HIV infection. J Pediatr. 1995;126:710–5.

    Article  CAS  PubMed  Google Scholar 

  4. Laughton B, et al. Early antiretroviral therapy improves neurodevelopmental outcomes in infants. AIDS. 2012;26(13):1859–90.

    Article  CAS  Google Scholar 

  5. Banks L, et al. The relationship between HIV and prevalence of disabilities in the sub-Saharan Africa: systematic review. Tropical Med Int Health. 2015;20(4):411–29.

    Article  Google Scholar 

  6. Mpango RS, et al. Prevalence, correlates for early neurological disorders and association with functioning among children and adolescents with HIV/AIDS in Uganda. BMC Psychiatry. 2019;19(34):1–7.

    Google Scholar 

  7. Charoudi A, Wagner TA, Persaud D. CNS persistence of HIV-1 in children: the untapped reservoir. Curr HIV/AIDS Rep. 2018;15:382–7.

    Article  Google Scholar 

  8. Dianconou, et al. Diagnosing HIV associated cerebral diseases—the importance of neuropathology in understanding HIV. Rom J Morph Embryol. 2016;57(2):740–7.

    Google Scholar 

  9. French MA. IRIS-reappraisal. Clin Infect Dis. 2009;48(1):101–7.

    Article  PubMed  Google Scholar 

  10. Budka H, Wiley CA, Kleihues P, et al. HIV associated disease of the nervous system: review of nomenclature and proposal for neuropathology-based terminology. Brain Pathol. 1991;1:143–52.

    Article  CAS  PubMed  Google Scholar 

  11. Seihean D, et al. HIV-1 associate/motor complex: absence of neuronal loss on the cerebral neocortex. Neurology. 1993;43:1492–9.

    Article  Google Scholar 

  12. Johan R, et al. Neuroimaging findings in children perinatally infected with HIV. Pediatric Infection Dis J. 1998;17(8):753–4.

    Article  Google Scholar 

  13. Brouwers P. Neuropsychological function in children with symptomatic HIV disease. Arch Neurol. 1995;52(1):39–44.

    Article  CAS  PubMed  Google Scholar 

  14. Husson RN, et al. Cerebral artery aneurysms in children infected with HIV. J Paediatr. 1992;121:927–30.

    Article  CAS  Google Scholar 

  15. Schiefflein JS. Central nervous system vasculopathy in HIV-infected children enrolled in the pediatric AIDS Clinical Trials Group 219/219c study. J Pediat Infect Dis. 2013;2(1):50–6.

    Article  Google Scholar 

  16. Dalakas MM, et al. Mitochondrial myopathy caused by long-term Zidovudine therapy. NEJM. 1990;322(4):1098–105.

    Article  CAS  PubMed  Google Scholar 

  17. Van Rie A, et al. Neurologic and neurodevelopmental manifestations of pediatric HIV/AIDS: a global perspective. Eur J Paediatr Neurol. 2007;11:1–9.

    PubMed  Google Scholar 

  18. Woulters P, et al. CNS involvement: manifestations, evaluation and pathogenesis. In: Wilfort PC, editor. Pediatric AIDS. The challenge of HIV Infection in Infants, children and Adolescents. Lippincott: Wilkins Williams; 1988.

    Google Scholar 

  19. Wolters P, Brouwers P, Civitello L. Receptive and expressive language function of children with symptomatic HIV infection and relationship with disease parameters: a longitudinal 24-month follow-up study. AIDS. 1997;11(9):1135–44.

    Article  CAS  PubMed  Google Scholar 

  20. CDC. 1994 Revised classification system for HIV infection in children less than 13 years old. MMWR. 1994;43(RR-12)

    Google Scholar 

  21. Mann T, et al. HIV encephalopathy with bilateral lower limb spasticity: upper limb motor function and level of activity and participation. Develop Med Child Neurol. 2017;59:412–9.

    Article  PubMed  Google Scholar 

  22. Rowland L. HIV related neuromuscular diseases: nemaline myopathy, amyotrophic latera sclerosis and bibrachial amyotrophic diplegia. Acta Myol. 2011;30:29–31.

    CAS  PubMed  PubMed Central  Google Scholar 

  23. Schutz SG. HIV- related neuropathy: current perspectives. HIV/AIDS-research and. Palliat Care. 2013;5(1):243–51.

    Google Scholar 

  24. Peters RP, et al. Clinical assessment of peripheral neuropathy in HIV infected children on antiretroviral therapy in South Africa. Curr Opin HIV AIDS. 2014;9(1):521–6.

    Google Scholar 

  25. Maritz J, et al. HIV neuropathy in south Africans: frequency, characteristics and risk factors. Muscle Nerve. 2010;41(5):599–606.

    PubMed  Google Scholar 

  26. Herzberg U, Sagen J. Peripheral nerve exposure to HIV viral envelope gp120 induces neuropathic pain and spinal gliosis. J Neuroimmunol. 2001;116(1):29–39.

    Article  CAS  PubMed  Google Scholar 

  27. Brouwers P, et al. Relation between stage of disease and neurobehavioral measures in children with symptomatic HIV disease. AIDS. 1999;9(7):713–20.

    Article  Google Scholar 

  28. Phillips N, et al. HIV-associated cognitive impairment in perinatally infected children: a meta-analysis. Pediatrics. 2016;138:1–11.

    Article  Google Scholar 

  29. Smith R. Impact of HIV severity on cognitive and adaptive functioning during childhood and adolescence. Pediatr Infect Dis J. 2012;31(6):1–11.

    Article  Google Scholar 

  30. Kalembo FW, Kendall M, Chimwaza AF. Prevalence and factors associated with emotional and behavioural difficulties among children living with HIV in Malawi: a cross-sectional study. BMC Psychiatry. 2019;19(60):1–14.

    Google Scholar 

  31. Redmond S. Longitudinal evaluation of language impairment in youth with perinatally acquired HIV and youth with perinatal HIV exposure. J Paed Infect Dis. 2016;5:s33–40.

    Article  Google Scholar 

  32. Davis-McFarland E. Language and oral-motor development and disorders in young infants and young toddler’s wit human immunodeficiency virus. Semin Speech Lang. 2000;21(1):19–36.

    Article  CAS  PubMed  Google Scholar 

  33. Ensink RJH, Kuper H. Is hearing impairment associated with HIV? A systematic review of data from low- and middle-income countries. Trop Med Int Health. 2017;22(12):1493–504.

    Article  PubMed  Google Scholar 

  34. Layton TL, Davids-McFarland E. Pediatric human immunodeficiency and AIDS: an overview. Semin Speech Lang. 2000;21(1):7–17.

    Article  CAS  PubMed  Google Scholar 

  35. Bearden D, Steinhoff A, Dlugos AP. Early antiretroviral therapy is protective against epilepsy in children with HIV infection in Botswana. J Acquir Def Syndr. 2015;69(2):193–9.

    Article  CAS  Google Scholar 

  36. Samia P, et al. Prevalence of seizures in children with HIV. J Child Neurol. 2013;28(3):297–302.

    Article  PubMed  Google Scholar 

  37. Madhi SA, et al. Impact of HIV-type 1 infection on the epidemiology and outcome of bacterial meningitis in south African children. Int J infect Dis. 2001;5:119–25.

    Article  CAS  PubMed  Google Scholar 

  38. Pormohammad A, et al. Human immunodeficiency virus in patients with tuberculous meningitis: systematic review and meta-analysis. Trop Med Int Health. 2018;23(6):589–95.

    Article  PubMed  Google Scholar 

  39. Rowe J, et al. Diagnosis and Management of Tuberculous Meningitis in HIV-Infected Pedaitric Patients. Pediatric Infect Dis J. 2009;28(2):147–8.

    Article  PubMed  Google Scholar 

  40. Mofenson LM, et al. Guidelines for the prevention and treatment of opportunistic infections among HIV-exposed and HIV-infected children: recommendations from CDC, the National Institutes of Health, the HIV Medicine Association of the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the American Academy of Pediatrics. MMWR Recomm Rep. 2009;58(RR-11):1.

    PubMed  Google Scholar 

  41. Hoare J, et al. Systematic review of neuroimaging studies in vertically transmitted HIV positive children and adolescents. Metab Brain/dis. 2014;29:221–9.

    Article  Google Scholar 

  42. Gottumukkala RV, et al. Imaging of the brain in patients with HIV infection. Top Magn Reson Imaging. 2014;23(5):275–91.

    Article  PubMed  Google Scholar 

  43. Ackermann C, Van Toorn R, Androiuku S. Human immunodeficiency virus-related cerebral white matter disease in children. Pediatr Radiol. 2019;49(5):652–62.

    Article  PubMed  Google Scholar 

  44. Weiss ZF. Posterior reversible encephalopathy syndrome in a patient with HIV/AIDS and immune reconstitution syndrome: case study and literature review. Oxford Med Rep. 2018;8:264–7.

    Google Scholar 

  45. Boivin MJ, Rusienor-Escudero H, Familiar-Lopez I. CNS impact of perinatal HIV infection and early treatment: the need for behavioral rehabilitative interventions along with medical treatment and care. Curr HIV/AIDS Rep. 2017;13(6):318–27.

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Paediatrics and Child Health, Nelson R Mandela School of Medicine, UKZN, Durban, South Africa

    Lawrence Mubaiwa

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  1. Lawrence Mubaiwa
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Correspondence to Lawrence Mubaiwa .

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Editors and Affiliations

  1. Department of Paediatrics and Child Health, University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa

    Raziya Bobat

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Mubaiwa, L. (2020). HIV Related CNS Disorders in Children. In: Bobat, R. (eds) HIV Infection in Children and Adolescents. Springer, Cham. https://doi.org/10.1007/978-3-030-35433-6_8

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