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Burn Scar Treatment

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Handbook of Burns Volume 2

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Abstract

Scar formation is considered as an integrative part of the complex and dynamic process of normal physiological wound healing to restore skin integrity following injury and is referred to as the maturation phase. This phase is dominated by fibroblasts. The pivotal feature of this process is the synthesis, deposition, and remodeling of collagen, the major structural substance of connective tissue. The collagen deposition in normal wound healing peaks by the third week after injury. Collagen remodeling is characterized by a (balanced) continuous synthesis and degradation of collagen and is observed already early during the wound healing process. The degradation of wound collagen is controlled by a variety of enzymes such as collagenases (e.g., MMP-1) derived from granulocytes, macrophages, keratinocytes, and fibroblasts. On the other hand, the expression and activity of collagenases is tightly controlled by cytokines.

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Authors and Affiliations

  1. Burns Unit, Wound Healing Unit, Lapeyronie Hospital, Montpellier University Hospital, Montpellier Cedex, France

    Luc Teot, Sami Otman, Antonio Brancati & Rainer Mittermayr

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  1. Luc Teot
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  2. Sami Otman
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  3. Antonio Brancati
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  4. Rainer Mittermayr
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Editors and Affiliations

  1. Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University of Graz, Graz, Austria

    Lars-Peter Kamolz

  2. Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

    Marc G. Jeschke

  3. Department of Plastic and Hand Surgery, University Hospital of Erlangen, Friedrich-Alexander University of Erlangen-Nürnberg, Erlangen, Germany

    Raymund E. Horch

  4. Department of Plastic and Hand Surgery, Evangelische Elisabeth Klinik Krankenhau, Berlin, Germany

    Markus Küntscher

  5. Department of Burns & Reconstructive Surgery, Masaryk University, Brno, Czech Republic

    Pavel Brychta

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Teot, L., Otman, S., Brancati, A., Mittermayr, R. (2020). Burn Scar Treatment. In: Kamolz, LP., Jeschke, M.G., Horch, R.E., Küntscher, M., Brychta, P. (eds) Handbook of Burns Volume 2. Springer, Cham. https://doi.org/10.1007/978-3-030-34511-2_6

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