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Perspectives on Biomaterial-Associated Infection: Pathogenesis and Current Clinical Demands

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Racing for the Surface

Abstract

In this chapter, an overview of current medical implant devices and infection problems associated with implantation is provided, bridging the gap between material engineering and clinical practice. The pathogenesis, common pathogens, and infection sites are listed, alongside the details of up-to-date strategies and guidelines for diagnosis and treatment of biomaterials-associated infections. Through the combined understanding of microbial pathogenicity, drug resistance, patients’ immune response processes, and current clinical practices, we can tackle the problem of biomaterials-associated infection via multidisciplinary approaches. To meet the clinical demands and challenges in future, strategic design of intelligent biomaterials is in need to reduce implantation device-caused infections, improving the patient’s quality of life.

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Acknowledgments

This work was financially supported by the National Key R&D Program of China (2018YFC1105402 and 2017YFA0207202), the National Natural Science Foundation of China (21875189 and 81601553), Key R&D Program of Jiangsu Province (BE2017740), the Natural Science Foundation of Zhejiang Province (LGF19H200005), and the Fundamental Research Funds for the Central Universities.

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Authors and Affiliations

  1. Xi’an Institute of Flexible Electronics (IFE) and Xi’an Institute of Biomedical Materials and Engineering (IBME), Northwestern Polytechnical University (NPU), Xi’an, Shaanxi, People’s Republic of China

    Dan Bai, Jingjie Chen, Peng Li & Wei Huang

Authors
  1. Dan Bai
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  2. Jingjie Chen
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  3. Peng Li
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  4. Wei Huang
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Corresponding author

Correspondence to Peng Li .

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Editors and Affiliations

  1. Department of Orthopaedics, West Virginia University, Morgantown, WV, USA

    Bingyun Li

  2. Microbiology Lab, AO Research Institute Davos, Davos Platz, Graubünden, Switzerland

    Thomas Fintan Moriarty

  3. Department of Chemical Engineering, Northeastern University, Boston, MA, USA

    Thomas Webster

  4. Engineering and Medicine, University of Manitoba, Winnipeg, MB, Canada

    Malcolm Xing

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Bai, D., Chen, J., Li, P., Huang, W. (2020). Perspectives on Biomaterial-Associated Infection: Pathogenesis and Current Clinical Demands. In: Li, B., Moriarty, T., Webster, T., Xing, M. (eds) Racing for the Surface. Springer, Cham. https://doi.org/10.1007/978-3-030-34475-7_4

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