Engineering Approaches to Create Antibacterial Surfaces on Biomedical Implants and Devices



Bacterial adhesion and biofilm formation on biomedical surfaces remain the annoying problems in global public health, causing severe infectious diseases and increasing health care costs. Moreover, the continued increase in the number of multidrug-resistant bacteria and their fast evolution induce a serious concern with the lack of development of new antimicrobials. These problems have initiated numerous research efforts to develop more effective antimicrobial surfaces through different engineering approaches to prohibit bacterial adhesion and subsequent biofilm formation. In this review, we summarize the engineering technologies for constructing antibacterial surfaces from the conventional to the cutting-edge strategies. Most of the traditional methods are based on the antifouling coatings and the release of toxic biocides from the chemically modified substrates. Antimicrobial nanoparticles can actively inhibit biofilm formation or other essential processes in the drug resistance mechanisms of bacteria. Thus, the combined use of bactericidal nanoparticles and antifouling polymers for functionalized organic–inorganic platforms has been investigated to enhance antibacterial performance. In recent years, unique surface topographies of antibacterial, natural surfaces have been discovered and studied with the increased understanding of the interaction between bacteria and substrates. We introduce various natural surfaces and artificial implantable biomaterials, which present the bactericidal surface topographies, along with their bactericidal mechanisms and efficiency. The use of biomimetic, nanotextured surfaces is a promising approach to overcome the current challenges for the treatment of multidrug-resistant bacteria.


Antimicrobial Antifouling Bactericidal Implant Coating Surface engineering Functional surface Nanotechnology Nanostructure 



This work is partially supported by Dr. Jang’s startup funds provided from Department of Chemical Engineering and Herbert Wertheim College of Engineering at the University of Florida. The authors also gratefully acknowledge the helpful comments and suggestions of the reviewers, which have improved the presentation.


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Chemical EngineeringUniversity of FloridaGainesvilleUSA
  2. 2.School of Chemical and Biological Engineering, Seoul National UniversitySeoulRepublic of Korea

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