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Meningeal Lymphatic Pathway of Brain Clearing From the Blood After Haemorrhagic Injuries

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Oxygen Transport to Tissue XLI

Abstract

This seems to be the time to gain new knowledge about the meningeal lymphatic system and a deeper understanding of its anatomy and physiology. Although it is known that the meningeal lymphatics present in the layers of the brain, limited information is available about the role of this system in brain function. Here, for the first time we clearly demonstrate that the meningeal lymphatic pathway is involved in brain clearing from the blood after intracranial hemorrhage associated with hypoxia and forms a connective bridge between interstitial, cerebral spinal fluid and peripheral lymphatics. We also show that the development of methods to stimulate meningeal lymph flow after hemorrhagic evidence in the brain might be a neuroprotective strategy for effective recovery of the brain after a cerebrovascular catastrophe.

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Acknowledgments

This work was supported by grants from the Russian Science Foundation (18-15-00172): Visualization of the meningeal lymphatics, RFBR № 17-02-00358\18: SpO2 recording, grant from the Ministry of Science and Education № 17.1223.2017: Methods for BBB opening.

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Semyachkina-Glushkovskaya, O. et al. (2020). Meningeal Lymphatic Pathway of Brain Clearing From the Blood After Haemorrhagic Injuries. In: Ryu, PD., LaManna, J., Harrison, D., Lee, SS. (eds) Oxygen Transport to Tissue XLI. Advances in Experimental Medicine and Biology, vol 1232. Springer, Cham. https://doi.org/10.1007/978-3-030-34461-0_9

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