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Notch Signaling and Embryonic Development: An Ancient Friend, Revisited

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Notch Signaling in Embryology and Cancer

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1218))

Abstract

The evolutionary highly conserved Notch pathway, which first developed during evolution in metazoans and was first discovered in fruit flies (Drosophila melanogaster), governs many core processes including cell fate decisions during embryonic development. A huge mountain of scientific evidence convincingly demonstrates that Notch signaling represents one of the most important pathways that regulate embryogenesis from sponges, roundworms, Drosophila melanogaster, and mice to humans. In this review, we give a brief introduction on how Notch orchestrates the embryonic development of several selected tissues, summarizing some of the most relevant findings in the central nervous system, skin, kidneys, liver, pancreas, inner ear, eye, skeleton, heart, and vascular system.

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Abbreviations

BMP:

Bone morphogenetic protein

cKO:

Conditional knockout

CNS:

Central nervous system

DG:

Dentate gyrus

Dll:

Delta-like

E:

Embryonic day

FGF:

Fibroblast growth factor

Hes:

Hairy and enhancer of split

Hf:

Hair follicle

IP:

Intermediate progenitor

IPC:

Intermediate progenitor cell

KO:

Knockout

LV:

Lateral ventricle

LW:

Lateral wall

MET:

Mesenchymal-to-epithelial transition

NEPs:

Neuroepithelial cells

NICD:

Notch intracellular domain

NSCs:

Neural stem cells

OB:

Olfactory bulb

P:

Postnatal day

RA:

Retinoic acid

RGC:

Radial glia cell

RMS:

Rostral migratory stream

SGZ:

Subgranular zone

Shh:

Sonic hedgehog

SVZ:

Subventricular zone

VZ:

Ventricular zone

Wnt:

Wingless

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Correspondence to Jörg Reichrath .

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Reichrath, J., Reichrath, S. (2020). Notch Signaling and Embryonic Development: An Ancient Friend, Revisited. In: Reichrath, J., Reichrath, S. (eds) Notch Signaling in Embryology and Cancer. Advances in Experimental Medicine and Biology, vol 1218. Springer, Cham. https://doi.org/10.1007/978-3-030-34436-8_2

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