Abstract
Although a huge number of Green Chemistry metrics are available and more simply applicable with respect to LCA, their intrinsic less comprehensive nature could in some cases represent a limiting factor for a trustworthy evaluation of the environmental and human health impacts assessment associated to that specific chemical. Therefore, all of the chemical processes not specifically based on a chemical reaction (e.g., the extraction of a particular phytochemical compound from plant matrices) are far from being assessed by most of these metrics. LCA methodology-based evaluations for chemical processes are not limited by a mere chemical reaction equation, being also able to account for time and energy contributions together with all of the possible environmental loads associated to a particular process or product. This chapter will first overview the most widely employed Green Chemistry metrics. The possibility to integrate those metrics with the all-encompassing LCA methodology will be also accurately and critically discussed. This chapter will also furnish important recommendations and guidelines on when and at which extent the application of LCA should be highly suggested at a laboratory scale.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
ACS Green Chemistry Institute pharmaceutical roundtable 2018. https://www.acs.org/content/acs/en/greenchemistry/research-innovation/tools-for-green-chemistry.html#process-mass-intensity-calculator. Accessed 17 Apr 2019
Albini A, Protti S (2016) Green metrics, an abridged glossary. In: Paradigms in Green Chemistry and technology, Springer Briefs in Green Chemistry for Sustainability. Springer, p 11
Allen DT, Hwang BJ, Licence P et al (2015) Advancing the use of sustainability metrics. ACS Sustain Chem Eng 3:2359–2360
Anastas PT, Warner JC (1998) Green Chemistry: theory and practice. Oxford University Press, New York
Anastas PT, Zimmerman JB (2003) Design through the 12 principles of green engineering. Environ Sci Technol 37:94A–101A
Andraos J (2005) Unification of reaction metrics for Green Chemistry: application to reaction analysis. Org Process Res Dev 9:149–163
Andraos J (2009) Global Green Chemistry metrics analysis algorithm and spreadsheets: evaluation of the material efficiency performances of synthesis plans for oseltamivir phosphate (Tamiflu) as a test case. Org Process Res Dev 13:161–185
Andraos J (2016) Critical evaluation of published algorithms for determining material efficiency green metrics of chemical reactions and synthesis plans. ACS Sustain Chem Eng 4:1917–1933
Andraos J, Mastronardi ML, Hoch LB et al (2016) Critical evaluation of published algorithms for determining environmental and hazard impact green metrics of chemical reactions and synthesis plans. ACS Sustain Chem Eng 4:1934–1945
Armenta S, Garrigues S, de la Guardia M (2008) Green analytical chemistry. TrAC Trends Anal Chem 27:497–511
Baldi G, Bitossi M, Barzanti A (2008) US Patent 0317959 A1
Becker H (2001) Organikum: organisch-chemisches Grundpraktikum. Wiley-VCH, Weinheim
Bianchini R, Corsi M, Bonanni M (2014) WO Patent 2014177528A1
Caramazana P, Dunne P, Gimeno-Fabra M et al (2017) Assessing the life cycle environmental impacts of titania nanoparticle production by continuous flow solvo/hydrothermal syntheses. Green Chem 19:1536–1547
Caramazana P, Dunne P, Gimeno-Fabra M et al (2018) A review of the environmental impact of nanomaterial synthesis using continuous flow hydrothermal synthesis. Curr Opin Green Sustain Chem 12:57–62
Cespi D, Passarini F, Vassura I et al (2016) Butadiene from biomass, a life cycle perspective to address sustainability in the chemical industry. Green Chem 18:1625–1638
Chemat F, Vian MA, Cravotto G (2012) Green extraction of natural products: concept and principles. Int J Mol Sci 13:8615–8627
Dallinger D, Kappe CO (2017) Why flow means green—evaluating the merits of continuous processing in the context of sustainability. Curr Opin Green Sustain Chem 7:6–12
Do JL, Friscic T (2017) Mechanochemistry: a force of synthesis. ACS Cent Sci 3:13–19
Duarte RC, Ribeiro MGTC, Machado AASC (2015) Using green star metrics to optimize the greenness of literature protocols for syntheses. J Chem Educ 92:1024–1034
Ecoscale calculator website (2006) http://ecoscale.cheminfo.org/calculator. Accessed 17 Apr 2019
Eissen M, Metzger JO (2001) EATOS user manual website: http://www.metzger.chemie.uni-oldenburg.de/eatos/eatosmanual.pdf. Accessed 18 Apr 2001
Eissen M, Metzger JO (2002) Environmental performance metrics for daily use in synthetic chemistry. Chem Eur J 8:3581–3585
Eissen M, Metzger JO (2019) EATOS, environmental assessment tool for organic syntheses, Software website: http://www.metzger.chemie.uni-oldenburg.de/eatos/english.htm. Accessed 18 Apr 2019
Ferrari E, Pignedoli F, Imbriano C et al (2011) Newly synthesized curcumin derivatives: crosstalk between chemico–physical properties and biological activity. J Med Chem 54:8066–8077
Ferrari AM, Volpi L, Pini M et al (2019) Building a sustainability benchmarking framework of ceramic tiles based on Life Cycle Sustainability Assessment (LCSA). Resources 8:11
Freese U, Heinrich F, Rößner F (1999) Acylation of aromatic compounds on H-Beta zeolites. Catal Today 49:237–244
Hudlicky T, Frey DA, Koroniak L et al (1999) Toward a “reagent-free” synthesis. Green Chem 1:57–59
Hünig S, Märkl G, Sauer J (1979) Integriertes organisches praktikum. Verl Chemie, Weinheim
Leonelli C, Mason TJ (2010) Microwave and ultrasonic processing: now a realistic option for industry. Chem Eng Proc 49:885–900
Life+ Ecodefatting project website: http://www.life-ecodefatting.com. Accessed 19 Apr 2019
NOP (2019) Website: https://www.oc-praktikum.de/nop/en-article-why. Accessed 17 Apr 2019
Pabon HJJ (1964) A synthesis of curcumin and related compounds. Recl Trav Chim Pays-Bas 83:379–386
Pini M, Rosa R, Neri P et al (2015) Environmental assessment of a bottom-up hydrolytic synthesis of TiO2 nanoparticles. Green Chem 17:518–531
Ravelli D, Dondi D, Fagnoni M et al (2010) Titanium dioxide photocatalysis: an assessment of the of the environmental compatibility for the case of the functionalization of heterocyclics. Appl Catal B 99:442–447
Ravelli D, Protti S, Neri P et al (2011) Photochemical technologies assessed: the case of rose oxide. Green Chem 13:1876–1884
Ribeiro MGTC, Machado AASC (2013) Greenness of chemical reactions—limitations of mass metrics. Green Chem Lett Rev 6:1–18
Ribeiro MGTC, Costa DA, Machado AASC (2010) “Green Star”: a holistic Green Chemistry metric for evaluation of teaching laboratory experiments. Green Chem Lett Rev 3:149–159
Rosa R, Pini M, Neri P et al (2017) Environmental sustainability assessment of a new degreasing formulation for the tanning cycle within leather manufacturing. Green Chem 19:4571–4582
Rosa R, Ferrari E, Veronesi P (2018) From field to shelf: how microwave-assisted extraction techniques foster an integrated green approach. In: You KY (ed) Emerging microwave technologies in industrial, agricultural, medical and food processing. IntechOpen, London, pp 179–203
Sheldon RA (1992) Organic synthesis; past, present and future. Chem Ind (London): 903–904
Sheldon RA (1994) Consider the environmental quotient. ChemTech 24:38–47
Sheldon RA (2007) The E factor: fifteen years on. Green Chem 9:1273–1283
Sheldon RA (2018) Metrics of green chemistry and sustainability: past, present, and future. ACS Sustain Chem Eng 6:32–48
Stankiewicz A, Moulijn JA (2000) Process intensification: transforming chemical engineering. Chem Eng Prog 96:22–34
Vaccaro L, Lanari D, Marrocchi A et al (2014) Flow approaches towards sustainability. Green Chem 16:3680–3704
Van Aken K, Strekowski L, Patiny L (2006) EcoScale, a semi-quantitative tool to select an organic preparation based on economical and ecological parameters. Beilstein J Org Chem 2. https://doi.org/10.1186/1860-5397-2-3
Vogel AI (1978) Vogel’s textbook of practical organic chemistry: including qualitative organic analysis. Longman, London
Zerazion E, Rosa R, Ferrari E et al (2016) Phytochemical compounds or their synthetic counterparts? A detailed comparison of the quantitative environmental assessment for the synthesis and extraction of curcumin. Green Chem 18:1807–1818
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Pini, M., Rosa, R., Neri, P., Ferrari, A.M. (2020). LCA Application to Chemical Synthesis at Laboratory Scale. In: Maranghi, S., Brondi, C. (eds) Life Cycle Assessment in the Chemical Product Chain. Springer, Cham. https://doi.org/10.1007/978-3-030-34424-5_5
Download citation
DOI: https://doi.org/10.1007/978-3-030-34424-5_5
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-34423-8
Online ISBN: 978-3-030-34424-5
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)
