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Mast Cells and Nanomaterials

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Interaction of Nanomaterials with the Immune System

Part of the book series: Molecular and Integrative Toxicology ((MOLECUL))

Abstract

Mast cells are an essential cell type within the immune system, playing a prominent role in a variety of cell functions—both adaptive and innate immune system as well as others. This central role throughout many systems means that any inappropriate modulation of mast cell activation can, and does, contribute to many pathologies, including lung disease, autoimmune disorders, and cancer as examples. There are many exogenous compounds that can lead to activation of mast cells and potentially cause irregular function, one of which are engineered nanomaterials (ENMs). The human population is ubiquitously exposed to a range of ENM at a high rate through exposure mechanisms associated with high mast cell number, making these nanoparticles suspect when considering mast cell dysfunction. Research looking into ENM-induced mast cell pathologies is underwhelming; however; current research on the topic shows a clear ability for ENM to change mast cell activity and must be further explored.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, Skaggs School of Pharmacy, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA

    Ryan P. Mendoza & Jared M. Brown

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  1. Ryan P. Mendoza
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  2. Jared M. Brown
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Correspondence to Jared M. Brown .

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  1. Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA

    James C. Bonner

  2. Department of Pharmaceutical Sciences Skaggs School of Pharmacy, University of Colorado, Aurora, CO, USA

    Jared M. Brown

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Mendoza, R.P., Brown, J.M. (2020). Mast Cells and Nanomaterials. In: Bonner, J., Brown, J. (eds) Interaction of Nanomaterials with the Immune System. Molecular and Integrative Toxicology. Springer, Cham. https://doi.org/10.1007/978-3-030-33962-3_4

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