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Genetics of Hypertension: The Human and Veterinary Perspectives

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Hypertension in the Dog and Cat

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Abstract

The health burden associated with hypertension in the world is very large. Current estimates suggest that there are over 1 billion individuals with hypertension worldwide with the World Health Organisation estimating that this will increase to 1.5 billion by 2025. Between 35% and 45% of individuals over 25 years demonstrate hypertension with prevalence varying with geographical location and socioeconomic status. In humans, a continuous and incremental risk exists between blood pressure (BP) and cardiovascular disease, stroke and kidney disease. The significant health and economic impact of hypertension has, therefore, driven the requirement for a better understanding of factors, including genetic factors, that may contribute to the development of hypertension. An understanding of these genetic associations might not only improve individual and population risk prediction but, more importantly, may identify novel pathophysiological pathways that are involved in BP regulation and which may also act as pathway targets for new anti-hypertensive drug development assisting with personalisation of anti-hypertensive therapy.

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Notes

  1. 1.

    http://www.who.int/cardiovascular_diseases/publications/global_brief_hypertension/en/

  2. 2.

    https://www.omim.org

  3. 3.

    1000 Genome project; http://www.internationalgenome.org/about/

  4. 4.

    ENCODE; https://www.genome.gov/10005107/the-encode-project-encyclopedia-of-dna-elements/

  5. 5.

    99 Lives Cat Genome Sequencing Initiative: http://felinegenetics.missouri.edu/99lives

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Authors and Affiliations

  1. Department of Clinical Sciences and Services, Royal Veterinary College, University of London, Hertfordshire, UK

    Rosanne E. Jepson

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  1. Rosanne E. Jepson
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Correspondence to Rosanne E. Jepson .

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  1. Department of Comparative Biomedical Sciences, Royal Veterinary College University of London, London, UK

    Jonathan Elliott

  2. Department of Clinical Sciences and Services, Royal Veterinary College University of London, Hertfordshire, UK

    Harriet M. Syme

  3. Department of Clinical Sciences and Services, Royal Veterinary College University of London, Hertfordshire, UK

    Rosanne E. Jepson

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Jepson, R.E. (2020). Genetics of Hypertension: The Human and Veterinary Perspectives. In: Elliott, J., Syme, H., Jepson, R. (eds) Hypertension in the Dog and Cat. Springer, Cham. https://doi.org/10.1007/978-3-030-33020-0_6

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