Abstract
The presence of drusen is the main hallmark of early/intermediate age-related macular degeneration (AMD). Therefore, automated drusen segmentation is an important step in image-guided management of AMD. There are two common approaches to drusen segmentation. In the first, the drusen are segmented directly as a binary classification task. In the second approach, the surrounding retinal layers (outer boundary retinal pigment epithelium (OBRPE) and Bruch’s membrane (BM)) are segmented and the remaining space between these two layers is extracted as drusen. In this work, we extend the standard U-Net architecture with spatial pyramid pooling components to introduce global feature context. We apply the model to the task of segmenting drusen together with BM and OBRPE. The proposed network was trained and evaluated on a longitudinal OCT dataset of 425 scans from 38 patients with early/intermediate AMD. This preliminary study showed that the proposed network consistently outperformed the standard U-net model.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Wong, W.L., et al.: Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Glob. health 2(2), e106–e116 (2014)
Schlanitz, F.G., et al.: Drusen volume development over time and its relevance to the course of age-related macular degeneration. Br. J. Ophthalmol. 101(2), 198–203 (2017)
Gorgi Zadeh, S., et al.: CNNs enable accurate and fast segmentation of drusen in optical coherence tomography. In: Cardoso, M.J., et al. (eds.) DLMIA/ML-CDS -2017. LNCS, vol. 10553, pp. 65–73. Springer, Cham (2017). https://doi.org/10.1007/978-3-319-67558-9_8
Khalid, S., Akram, M.U., Hassan, T., Jameel, A., Khalil, T.: Automated segmentation and quantification of Drusen in Fundus and optical coherence tomography images for detection of ARMD. J. Digit. Imaging 31(4), 464–476 (2018). https://doi.org/10.1007/s10278-017-0038-7
Novosel, J., Vermeer, K.A., de Jong, J.H., Wang, Z., van Vliet, L.J.: Joint segmentation of retinal layers and focal lesions in 3-D OCT data of topologically disrupted retinas. IEEE Trans. Med. Imaging 36(6), 1276–1286 (2017)
Fang, L., et al.: Automatic segmentation of nine retinal layer boundaries in OCT images of non-exudative AMD patients using deep learning and graph search. Biomed. Opt. Express 8(5), 2732–2744 (2017)
Shah, A., et al.: Multiple surface segmentation using convolution neural nets: application to retinal layer segmentation in OCT images. Biomedical Optics Express 9(9), 4509–4526 (2018)
Zhao, H., Shi, J., Qi, X., Wang, X., Jia, J.: Pyramid scene parsing network. In: CVPR (2017)
He, K., Zhang, X., Ren, S., Sun, J.: Spatial pyramid pooling in deep convolutional networks for visual recognition. CoRR abs/1406.4729 (2014)
Yu, F., Koltun, V.: Multi-scale context aggregation by dilated convolutions. arXiv preprint arXiv:1511.07122 (2015)
Gu, Z., et al.: DeepDisc: optic disc segmentation based on atrous convolution and spatial pyramid pooling. In: Stoyanov, D., et al. (eds.) OMIA/COMPAY -2018. LNCS, vol. 11039, pp. 253–260. Springer, Cham (2018). https://doi.org/10.1007/978-3-030-00949-6_30
Zhao, R., et al.: Automated Drusen detection in dry age-related macular degeneration by multiple-depth, en face optical coherence tomography. Biomed. Opt. Express 8(11), 5049 (2017)
Ronneberger, O., Fischer, P., Brox, T.: U-Net: convolutional networks for biomedical image segmentation. In: Navab, N., Hornegger, J., Wells, W., Frangi, A. (eds.) MICCAI 2015. LNCS, vol. 9351, pp. 234–241. Springer, Cham (2015). https://doi.org/10.1007/978-3-319-24574-4_28
Crum, W.R., Camara, O., Hill, D.L.G.: Generalized overlap measures for evaluation and validation in medical image analysis. IEEE Trans. Med. Imaging 25(11), 1451–1461 (2006). Nov
Chen, X., Niemeijer, M., Zhang, L., Lee, K., Abràmoff, M.D., Sonka, M.: Three-dimensional segmentation of fluid-associated abnormalities in retinal OCT: probability constrained graph-search-graph-cut. IEEE-TMI 31(8), 1521–1531 (2012)
Acknowledgment
This work was funded by the Christian Doppler Research Association, the Austrian Federal Ministry for Digital and Economic Affairs and the National Foundation for Research, Technology and Development. We thank the NVIDIA corporation for a GPU donation.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this paper
Cite this paper
Asgari, R., Waldstein, S., Schlanitz, F., Baratsits, M., Schmidt-Erfurth, U., Bogunović, H. (2019). U-Net with Spatial Pyramid Pooling for Drusen Segmentation in Optical Coherence Tomography. In: Fu, H., Garvin, M., MacGillivray, T., Xu, Y., Zheng, Y. (eds) Ophthalmic Medical Image Analysis. OMIA 2019. Lecture Notes in Computer Science(), vol 11855. Springer, Cham. https://doi.org/10.1007/978-3-030-32956-3_10
Download citation
DOI: https://doi.org/10.1007/978-3-030-32956-3_10
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-32955-6
Online ISBN: 978-3-030-32956-3
eBook Packages: Computer ScienceComputer Science (R0)