Abstract
Automated skin lesion analysis is very crucial in clinical practice, as skin cancer is among the most common human malignancy. Existing approaches with deep learning have achieved remarkable performance on this challenging task, however, heavily relying on large-scale labelled datasets. In this paper, we present a novel active learning framework for cost-effective skin lesion analysis. The goal is to effectively select and utilize much fewer labelled samples, while the network can still achieve state-of-the-art performance. Our sample selection criteria complementarily consider both informativeness and representativeness, derived from decoupled aspects of measuring model certainty and covering sample diversity. To make wise use of the selected samples, we further design a simple yet effective strategy to aggregate intra-class images in pixel space, as a new form of data augmentation. We validate our proposed method on data of ISIC 2017 Skin Lesion Classification Challenge for two tasks. Using only up to 50% of samples, our approach can achieve state-of-the-art performances on both tasks, which are comparable or exceeding the accuracies with full-data training, and outperform other well-known active learning methods by a large margin.
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References
Codella, N.C., et al.: Skin lesion analysis toward melanoma detection: a challenge at the 2017 international symposium on biomedical imaging (ISBI), hosted by the international skin imaging collaboration (ISIC). In: ISBI, pp. 168–172 (2018)
Diaz, I.G.: DermaKNet: incorporating the knowledge of dermatologists to convolutional neural networks for skin lesion diagnosis. IEEE J. Biomed. Health Inf. 23, 547–559 (2018)
Esteva, A., et al.: Dermatologist-level classification of skin cancer with deep neural networks. Nature 542(7639), 115 (2017)
Huang, S.J., Jin, R., Zhou, Z.H.: Active learning by querying informative and representative examples. In: NIPS, pp. 892–900 (2010)
Lei, B., Jinman, K., Euijoon, A., Dagan, F.: Automatic skin lesion analysis using large-scale dermoscopy image and deep residual networks. arXiv:1703.04197 (2017)
Mahapatra, D., Bozorgtabar, B., Thiran, J.-P., Reyes, M.: Efficient active learning for image classification and segmentation using a sample selection and conditional generative adversarial network. In: Frangi, A.F., Schnabel, J.A., Davatzikos, C., Alberola-López, C., Fichtinger, G. (eds.) MICCAI 2018. LNCS, vol. 11071, pp. 580–588. Springer, Cham (2018). https://doi.org/10.1007/978-3-030-00934-2_65
Settles, B.: Active learning literature survey. Computer Sciences Technical Report 1648, University of Wisconsin-Madison (2009)
Xue, C., Dou, Q., Shi, X., Chen, H., Heng, P.A.: Robust learning at noisy labeled medical images: applied to skin lesion classification. ISBI (2019)
Yang, L., Zhang, Y., Chen, J., Zhang, S., Chen, D.Z.: Suggestive annotation: a deep active learning framework for biomedical image segmentation. In: Descoteaux, M., Maier-Hein, L., Franz, A., Jannin, P., Collins, D.L., Duchesne, S. (eds.) MICCAI 2017. LNCS, vol. 10435, pp. 399–407. Springer, Cham (2017). https://doi.org/10.1007/978-3-319-66179-7_46
Zhang, H., Cisse, M., Dauphin, Y.N., Lopez-Paz, D.: mixup: beyond empirical risk minimization. In: ICLR (2017)
Zhang, J., Xie, Y., Wu, Q., Xia, Y.: Skin lesion classification in dermoscopy images using synergic deep learning. In: Frangi, A.F., Schnabel, J.A., Davatzikos, C., Alberola-López, C., Fichtinger, G. (eds.) MICCAI 2018. LNCS, vol. 11071, pp. 12–20. Springer, Cham (2018). https://doi.org/10.1007/978-3-030-00934-2_2
Zheng, H., et al.: Biomedical image segmentation via representative annotation. In: AAAI (2019)
Zhou, Z., Shin, J.Y., Zhang, L., Gurudu, S.R., Gotway, M.B., Liang, J.: Fine-tuning convolutional neural networks for biomedical image analysis: Actively and incrementally. In: CVPR, pp. 4761–4772 (2017)
Acknowledgments
The work described in this paper was supported by the 973 Program with Project No. 2015CB351706, the National Natural Science Foundation of China with Project No. U1613219 and the Hong Kong Innovation and Technology Commission through the ITF ITSP Tier 2 Platform Scheme under Project ITS/426/17FP.
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Shi, X., Dou, Q., Xue, C., Qin, J., Chen, H., Heng, PA. (2019). An Active Learning Approach for Reducing Annotation Cost in Skin Lesion Analysis. In: Suk, HI., Liu, M., Yan, P., Lian, C. (eds) Machine Learning in Medical Imaging. MLMI 2019. Lecture Notes in Computer Science(), vol 11861. Springer, Cham. https://doi.org/10.1007/978-3-030-32692-0_72
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