Abstract
Accurate analysis of the fibrosis stage plays very important roles in follow-up of patients with chronic hepatitis B infection. In this paper, a deep learning framework is presented for automatically liver fibrosis prediction. On contrary of previous works, our approach can take use of the information provided by multiple ultrasound images. An indicator-guided learning mechanism is further proposed to ease the training of the proposed model. This follows the workflow of clinical diagnosis and make the prediction procedure interpretable. To support the training, a dataset is well-collected which contains the ultrasound videos/images, indicators and labels of 229 patients. As demonstrated in the experimental results, our proposed model shows its effectiveness by achieving the state-of-the-art performance, specifically, the accuracy is 65.6% (20% higher than previous best).
J. Liu and W. Wang—Equal contribution.
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Schweitzer, A., Horn, J., Mikolajczyk, R.T., Krause, G., Ott, J.J.: Estimations of worldwide prevalence of chronic hepatitis B virus infection: a systematic review of data published between 1965 and 2013. The Lancet 386(10003), 1546–1555 (2015)
Stanaway, J.D., et al.: The global burden of viral hepatitis from 1990 to 2013: findings from the global burden of disease study 2013. The Lancet 388(10049), 1081–1088 (2016)
Denzer, U., Arnoldy, A., Kanzler, S., Galle, P.R., Dienes, H.P., Lohse, A.W.: Prospective randomized comparison of minilaparoscopy and percutaneous liver biopsy: diagnosis of cirrhosis and complications. J. Clin. Gastroenterol. 41(1), 103–110 (2007)
Wong, J.B., Koff, R.S.: Watchful waiting with periodic liver biopsy versus immediate empirical therapy for histologically mild chronic hepatitis C: a cost-effectiveness analysis. Ann. Intern. Med. 133(9), 665–675 (2000)
Dohan, A., Guerrache, Y., Boudiaf, M., Gavini, J.-P., Kaci, R., Soyer, P.: Transjugular liver biopsy: indications, technique and results. Diagn. Intervent. Imaging 95(1), 11–15 (2014)
Mojsilovic, A., Popovic, M., Markovic, S., Krstic, M.: Characterization of visually similar diffuse diseases from B-scan liver images using nonseparable wavelet transform. IEEE Trans. Med. Imaging 17(4), 541–549 (1998)
Yeh, W.-C., Huang, S.-W., Li, P.-C.: Liver fibrosis grade classification with B-mode ultrasound. Ultrasound Med. Biol. 29(9), 1229–1235 (2003)
Simonyan, K., Zisserman, A.: Very deep convolutional networks for large-scale image recognition. arXiv preprint arXiv:1409.1556 (2014)
Esteva, A., et al.: Dermatologist-level classification of skin cancer with deep neural networks. Nature 542(7639), 115 (2017)
Meng, D., Zhang, L., Cao, G., Cao, W., Zhang, G., Bing, H.: Liver fibrosis classification based on transfer learning and fcnet for ultrasound images. IEEE Access 5, 5804–5810 (2017)
Crespo, G., et al.: ARFI, FibroScan® elf, and their combinations in the assessment of liver fibrosis: a prospective study. J. Hepatol. 57(2), 281–287 (2012)
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Liu, J., Wang, W., Guan, T., Zhao, N., Han, X., Li, Z. (2019). Ultrasound Liver Fibrosis Diagnosis Using Multi-indicator Guided Deep Neural Networks. In: Suk, HI., Liu, M., Yan, P., Lian, C. (eds) Machine Learning in Medical Imaging. MLMI 2019. Lecture Notes in Computer Science(), vol 11861. Springer, Cham. https://doi.org/10.1007/978-3-030-32692-0_27
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DOI: https://doi.org/10.1007/978-3-030-32692-0_27
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