Skip to main content
Book cover

Reference Materials in Measurement and Technology

RMMT 2018: Reference Materials in Measurement and Technology pp 11–25Cite as

Metrological Assurance of Dioxin Measurements. A Certified Reference Material for Measuring the Dioxin Mass Fraction in Animal Fat

  • 189 Accesses

Abstract

This article presents information on the development of a new type of certified reference material (CRM) of the mass fraction of dioxins in animal fat, assured with metrological traceability. A procedure for preparing and certifying the CRM is provided. GC-LRMS in combination with isotopic dilution was used as an analytical method for establishing certified characteristics. The uncertainties induced by the CRM inhomogeneity and instability were estimated in order to account for their contribution to the combined uncertainty of the obtained certified values. In addition, the results of interlaboratory comparisons (ILC) studies for an experimental batch of the developed CRM are presented. Measurement results provided by ILC participants are shown to be in good agreement with the certified characteristics of the CRM. The certified values of the mass fractions of dioxins (PCDF group) in the CRM are established to vary from 1 to 1000 ng/kg, with the relative expanded uncertainty ranging from 10 to 20%.

Keywords

  • Certified reference materials
  • Dioxin
  • Certified value
  • Uncertainty
  • Traceability
  • Mass balance method
  • Inhomogeneity
  • Stability

This is a preview of subscription content, access via your institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • DOI: 10.1007/978-3-030-32534-3_2
  • Chapter length: 15 pages
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
eBook
USD   109.00
Price excludes VAT (USA)
  • ISBN: 978-3-030-32534-3
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD   149.99
Price excludes VAT (USA)
Hardcover Book
USD   199.99
Price excludes VAT (USA)
Learn about institutional subscriptions
Fig. 1
Fig. 2
Fig. 3

Abbreviations

HpCDD:

Heptachlorodibenzo-p-dioxins

HpCDF:

Heptachlorodibenzofurans

HxCDF:

Hexachlorodibenzofurans

HxCDD:

Hexachlorodibenzo-p-dioxins

OCDD:

Octachlorodibenzo-p-dioxin

OCDF:

Octachlorodibenzofuran

PeCDD:

Pentachlorodibenzo-p-dioxins

PeCDF:

Pentachlorodibenzofurans

TCDD:

Tetrachlorodibenzo-p-dioxins

TCDF:

Tetrachlorodibenzofurans

References

  1. The effects of herbicides in South Vietnam. Part A. Summary and conclusion (1974) National Academy of Sciences, Washington

    Google Scholar 

  2. Ambient water quality criteria 2,3,7,8-tetrachlorodibenzo-p-dioxin: report EPA-400/5-84/007 (1984) Office of water regulations and standards, Washington

    Google Scholar 

  3. Vysochin VI (1989) Dioxin and related compounds: analytical review. GPNTB SO AN SSSR, Novosibirsk (in Russ.)

    Google Scholar 

  4. Gough M (1986) Dioxin, agent orange: the facts. Plenum press, NY

    CrossRef  Google Scholar 

  5. Fedorov LA (1993) Dioxins as an environmental hazard: a retrospective and prospects. Nauka, Moscow (in Russ.)

    Google Scholar 

  6. Maistrenko VN, Klyuev NA (2004) Ecological and analytical monitoring of persistent organic pollutants. BINOM. Laboratoriya znanii, Moscow (in Russ.)

    Google Scholar 

  7. Drugov YS, Rodin AA (4th eds) (2006) Gas chromatographic analysis of polluted air: a practical guide. BINOM. Laboratoriya znanii, Moscow (in Russ.)

    Google Scholar 

  8. Registries of dioxins and furans. National and regional PCDD/PCDF emissions (1999) United Nations Environment Program, Geneva

    Google Scholar 

  9. Stockholm Convention on Persistent Organic Pollutants (2001) Stockholm

    Google Scholar 

  10. Pozdnyakov SP, Rumak VS, Sofronov GA, Umanova NV (2006) Dioxins and human health. Nauka, Saint Petersburg

    Google Scholar 

  11. TR CU 021/2011 Technical Regulations of the Customs Union “On food safety” (2018). Available via Eurasian Economic Union. https://docs.eaeunion.org/pd/ru-ru/0102880/pd_16052018. Accessed 20 Sept 2018

  12. Commission Regulation (EC) No 1881/2006 Setting maximum levels for certain contaminants in foodstuffs. Official J Eur Union 49 (L 364)

    Google Scholar 

  13. GOST 31792-2012 (2014) Fish, marine invertebrates and their products. Determination of dioxins and dioxin-like polychlorinated biphenyls by the chromatographic mass-spectrometric method. Standartinform, Moscow (in Russ.)

    Google Scholar 

  14. PND F 13.2: 3.64—08 (2014) Methods of measuring the mass concentration of polychlorinated dibenzo-n-dioxins and dibenzofurans in the atmospheric air of the working area using chromatography and mass spectrometry. Moscow (in Russ.)

    Google Scholar 

  15. Method 1613 Rev. B (1994) Tetra-through octa-chlorinated dioxins and furans by isotope dilution HRGC/HRMS, U.S. Environmental protection agency office of water engineering and analysis division, Washington, p 89

    Google Scholar 

  16. ISO 18073:2004 (2013) Water quality—determination of tetra- to octa-chlorinated dioxins and furans—method using isotope dilution HRGC/HRMS. ISO

    Google Scholar 

  17. EN 1948-2 (2006) Stationary source emissions—determination of the mass concentration of PCDDs/PCDFs and dioxin-like PCBs—part 2: extraction and clean-up of PCDDs/PCDFs

    Google Scholar 

  18. EN 1948-3 (2006) Stationary source emissions—determination of the mass concentration of PCDDs/PCDFs and dioxin-like PCBs—part 3: identification and quantification of PCDDs/PCDFs

    Google Scholar 

  19. JIS K 0311-1999 (1999) Method for determination of tetra-through octa-chlorodibenzo-p-dioxins, tetra-through octa-chlorodibenzofurans and coplanar polychlorobiphenyls in stationary source emissions, Japanese Standards Association

    Google Scholar 

  20. Mutual recognition of national measurement standards and calibration and measurement certificates issued by national metrological institutes. CIPM MRA Agreement of 14.10.1999 (1999). Available via ROSSTANDART Federal Information Foundation for ensuring the uniformity of measurements. https://fgis.gost.ru/fundmetrology/registry/7. Accessed 20 Sept 2018 (in Russ.)

  21. RMG 55-2003 GSI (2004) Standard samples of the composition of pure organic substances. Methods of testing. Main principles. Izdatel’stvo standartov, Moscow (in Russ.)

    Google Scholar 

  22. Duewer DL, Parris RM, White E, May WE, Elbaum H (2004) An approach to the metrologically sound traceable assessment of the chemical purity of organic reference materials. Special Publication NIST SP, 1012

    Google Scholar 

  23. Certified Reference Materials catalogue (2018) Joint Research Centre—Institute for Reference Materials and Measurements (JRC-IRMM). https://ec.europa.eu/jrc/en/reference-materials/catalogue. Accessed 20 Sept 2018

  24. Approved types of reference materials RF (2018) ROSSTANDART Federal Information Foundation for ensuring the uniformity of measurements, Moscow. https://fgis.gost.ru/fundmetrology/registry/19. Accessed 20 Sept 2018

  25. Wellington laboratories current catalogue inc 2016–2018 (2018) Wellington laboratories, Canada. https://well-labs.com/products/catalogue. Accessed 20 Sept 2018

  26. Dioxin and furan method standards, standard mixtures, and reference materials (2018) Cambridge Isotope Laboratories. http://shop.isotope.com/category.aspx?id=10032753. Accessed 20 Sept 2018

  27. Standard reference materials (2018) National Institute of Standards and Technology. https://www.nist.gov/srm

  28. MUK-99 (1999) Guidelines for the identification and isomer-specific determination of polychlorinated dibenzo-p-dioxins and dibenzofurans in meat, poultry, fish, products and by-products from them, as well as in other fat-containing products and feed by chromatography mass spectrometry. Moscow (in Russ.)

    Google Scholar 

  29. De Bièvre P (1993) Isotope dilution mass spectrometry as a primary method of analysis. Anal. Proc. https://doi.org/10.1039/ap9933000328

    CrossRef  Google Scholar 

  30. Milton MJT, Quinn TJ (2001) Metrologia 38:289–296

    CrossRef  CAS  Google Scholar 

  31. ILAC-G12:2000 Guidelines for the Requirements for the competence of reference material producers

    Google Scholar 

  32. Kaarls R (2018) The consultative committee for metrology in chemistry and biology—CCQM. J Chem Metrol 12(1):1–16. https://doi.org/10.25135/jcm.11.17.12.060

    CrossRef  Google Scholar 

  33. GOST ISO Guide 35—2015 (2016) Reference materials—general and statistical principles of certification. Standartinform, Moscow (in Russ.)

    Google Scholar 

  34. RMG 93–2015 (2016) GSI Evaluation of the metrological characteristics of certified reference materials. Standartinform, Moscow (in Russ.)

    Google Scholar 

  35. Budko AG, Mikheeva AYu, Krylov AI (2017) On the accuracy and reliability of the results of measurement of polychlorinated dibenzo-(p)-dioxins and dibenzofurans. The results of interlaboratory comparisons. In: Materials of the III All-Russian Conference “analytical chromatography and capillary electrophoresis”. Kuban State University, Krasnodar, 21–27 May 2017

    Google Scholar 

Download references

Acknowledgements

The authors express their sincere gratitude to the staff of the Scientific Production Association “Typhoon”, Scientific-Technical Centre of Radiation and Chemical Safety and Hygiene of the Federal Medical Biological Agency of Russia (STC RCSH), A. N. Severtsov Institute of Ecology and Evolution, Kuban State Agrarian University and Federal Office of Consumer Protection and Food Safety (BVL), Germany, for their participation in interlaboratory comparisons.

Author Contribution Statement

Budko A. G.: Preparation of the reference material, collection and analysis of experimental data, literature review, preparation of the manuscript draft;

Mikheeva A. Y.: Literature review, revision of the manuscript;

Krylov A. I.: Critical analysis and revision of the manuscript.

Author information

Authors and Affiliations

  1. D.I. Mendeleyev Institute for Metrology (VNIIM), Saint Petersburg, Russia

    Alexandra G. Budko, Alena Y. Mikheeva & Anatoliy I. Krylov

Authors
  1. Alexandra G. Budko
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Alena Y. Mikheeva
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Anatoliy I. Krylov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Alexandra G. Budko .

Editor information

Editors and Affiliations

  1. Ural Scientific Research Institute for Metrology, Ekaterinburg, Russia

    Dr. Sergei V. Medvedevskikh

  2. Ural Scientific Research Institute for Metrology, Ekaterinburg, Russia

    Olga N. Kremleva

  3. A.P. Vinogradov Institute of Geochemistry Siberian Branch, Russian Academy of Sciences, Irkutsk, Russia

    Dr. Irina E. Vasil’eva

  4. Ural Scientific Research Institute for Metrology, Ekaterinburg, Russia

    Dr. Egor P. Sobina

Rights and permissions

Reprints and Permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this paper

Verify currency and authenticity via CrossMark

Cite this paper

Budko, A.G., Mikheeva, A.Y., Krylov, A.I. (2020). Metrological Assurance of Dioxin Measurements. A Certified Reference Material for Measuring the Dioxin Mass Fraction in Animal Fat. In: Medvedevskikh, S., Kremleva, O., Vasil’eva, I., Sobina, E. (eds) Reference Materials in Measurement and Technology. RMMT 2018. Springer, Cham. https://doi.org/10.1007/978-3-030-32534-3_2

Download citation