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Pathology and Molecular Pathology of Hodgkin Lymphoma

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Hodgkin Lymphoma

Part of the book series: Hematologic Malignancies ((HEMATOLOGIC))

Abstract

Hodgkin lymphoma (HL) comprises two distinct disease entities, classical HL (cHL) and nodular lymphocyte-predominant HL (LPHL). They have in common that the tumor cells—Hodgkin and Reed-Sternberg (HRS) cells in cHL and lymphocyte-predominant (LP) cells in LPHL—are typically large, either mononucleated or multinucleated cells that represent at most a few percent of cells in the lymphoma tissue. The two forms of HL differ in numerous aspects of their histological picture, and the morphology of the lymphoma cells, their phenotype, and their genetic features. HRS and LP cells both derive from germinal center B cells, albeit likely from distinct subsets of these mature B cells. HRS cells have lost most of the B cell phenotype and gene expression pattern of their cellular origin. HRS cells show an activation of numerous signaling pathways, and particularly the NF-κB and JAK/STAT pathways are often constitutively activated through genetic lesions. Other genetic lesions contribute to immune evasion of the HRS cells.

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  1. Institute of Pathology, University of Würzburg, Würzburg, Germany

    Andreas Rosenwald

  2. Institute of Cell Biology (Cancer Research), Medical School, University of Duisburg-Essen, Essen, Germany

    Ralf Küppers

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    Andreas Engert

  2. Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Anas Younes

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Rosenwald, A., Küppers, R. (2020). Pathology and Molecular Pathology of Hodgkin Lymphoma. In: Engert, A., Younes, A. (eds) Hodgkin Lymphoma. Hematologic Malignancies. Springer, Cham. https://doi.org/10.1007/978-3-030-32482-7_3

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