Unsupervised Feature Selection via Adaptive Embedding and Sparse Learning for Parkinson’s Disease Diagnosis

  • Zhongwei Huang
  • Haijun Lei
  • Guoliang Chen
  • Shiqi Li
  • Hancong Li
  • Ahmed Elazab
  • Baiying LeiEmail author
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 11848)


Parkinson’s disease (PD) is known as a progressive neurodegenerative disease in elderly people. Apart from decelerating the disease exacerbation, early and accurate diagnosis also alleviates mental and physical sufferings and provides timely and appropriate medication. In this paper, we propose an unsupervised feature selection method via adaptive manifold embedding and sparse learning exploiting longitudinal multimodal neuroimaging data for classification and regression prediction. Specifically, the proposed method simultaneously carries out feature selection and dynamic local structure learning to obtain the structural information inherent in the neuroimaging data. We conduct extensive experiments on the publicly available Parkinson’s progression markers initiative (PPMI) dataset to validate the proposed method. Our proposed method outperforms other state-of-the-art methods in terms of classification and regression prediction performance.


Parkinson’s disease Unsupervised feature selection Adaptive manifold embedding Classification Regression prediction 



This work was supported partly by the Integration Project of Production Teaching and Research by Guangdong Province and Ministry of Education (No. 2012B091100495), Shenzhen Key Basic Research Project (No. JCYJ20170302153337765), Guangdong Pre-national Project (No. 2014GKXM054), and Guangdong Province Key Laboratory of Popular High Performance Computers (No. 2017B030314073).


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Zhongwei Huang
    • 1
  • Haijun Lei
    • 1
  • Guoliang Chen
    • 1
  • Shiqi Li
    • 1
  • Hancong Li
    • 1
  • Ahmed Elazab
    • 2
  • Baiying Lei
    • 2
    Email author
  1. 1.Key Laboratory of Service Computing and Applications, Guangdong Province Key Laboratory of Popular High Performance Computers, College of Computer Science and Software EngineeringShenzhen UniversityShenzhenChina
  2. 2.National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science CenterShenzhen UniversityShenzhenChina

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