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Chemoprevention in Oral Cancer

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Textbook of Oral Cancer

Part of the book series: Textbooks in Contemporary Dentistry ((TECD))

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Abstract

Despite a new understanding of the molecular biology of oral cancer and the development of promising new approaches for the treatment of oral cancer, this disease remains a major source of morbidity and mortality worldwide. Prevention of oral cancer, using pharmacologic or immunologic approaches, is a promising strategy to combat the devastating effects associated with the diagnosis of invasive malignancy. An understanding of the early molecular events leading to the development of cancer is critical to the identification of appropriate targets for early intervention. Refinement of clinical trial methodologies to assess efficacy in early-phase cancer prevention clinical trials and appropriate identification of high-risk individuals who are most likely to benefit from interventions are key to making progress. This chapter summarizes the state of knowledge and ongoing efforts in oral cancer prevention.

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Authors and Affiliations

  1. Division of Cancer Prevention, National Cancer Institute, Rockville, MD, USA

    Holli A. Loomans-Kropp & Eva Szabo

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  1. Holli A. Loomans-Kropp
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  2. Eva Szabo
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Correspondence to Eva Szabo .

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Editors and Affiliations

  1. Faculty of Dentistry, Oral & Craniofacial Sciences,, King’s College London, London, UK

    Saman Warnakulasuriya

  2. Department of Orofacial Sciences, Schools of Dentistry and Medicine, University of California San Francisco, San Francisco, CA, USA

    John S. Greenspan

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Loomans-Kropp, H.A., Szabo, E. (2020). Chemoprevention in Oral Cancer. In: Warnakulasuriya, S., Greenspan, J. (eds) Textbook of Oral Cancer. Textbooks in Contemporary Dentistry. Springer, Cham. https://doi.org/10.1007/978-3-030-32316-5_18

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  • DOI: https://doi.org/10.1007/978-3-030-32316-5_18

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