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Early Diagnosis of Oral Cancer

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Textbook of Oral Cancer

Part of the book series: Textbooks in Contemporary Dentistry ((TECD))

Abstract

The subject of detection and diagnosis timing for oral cancer has not been adequately studied and no robust conclusions can be reached with the current evidence. A majority of oral cancers are diagnosed in advanced stages (3 and 4) and have relatively poor prognosis. The reasons for this are not always clear but appear to be associated with low education levels about the disease in both populations at risk and primary care practitioners. Sets of heterogeneous data indicate that early diagnosis followed by swift implementation of therapy has superior outcomes and lower morbidity. Improved educational models may benefit future patients as well as the society at large.

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References

  1. Khunger M, Kumar U, Roy HK, Tiwari AK. Dysplasia and cancer screening in 21st century. APMIS. 2014;122:674–82.

    Article  Google Scholar 

  2. Lydiatt WM, Patel SG, O’Sullivan B, et al. Head and neck cancers-major changes in the American Joint Committee on Cancer. Eighth Edition. CA Cancer J Clin. 2017;67:122–37.

    Article  Google Scholar 

  3. Schiffman JD, Fisher PG, Gibbs P. Am Soc Clin Oncol Educ Book 2015;57–65. https://doi.org/10.14694/EdBook_AM.2015.35.57.

  4. Caverly TJ, Hayward RA, Reamer E, et al. Presentation of benefits and harms in US Cancer Screening and prevention guidelines: systematic review. J Natl Cancer Inst. 2016;108(6):djv436. https://doi.org/10.1093/jnci/djv436.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Guneri P, Epstein JB. Late stage diagnosis of oral cancer: components and possible solutions. Oral Oncol. 2014;50:1131–6.

    Article  Google Scholar 

  6. Weller D, Vedsted P, Rubin G, et al. The Aarhus statement: improving design and reporting of studies on early cancer diagnosis. Br J Cancer. 2012;106:1262–7.

    Article  Google Scholar 

  7. Varela-Centelles P, Lopez-Cedrun JL, Fernandez Sanroman J, et al. Key points and time intervals for early diagnosis in symptomatic oral cancer: a systematic review. Int J Oral Maxillofac Surg. 2017;46:1–10.

    Article  Google Scholar 

  8. Scott SE, Grunfeld EA, McGUrk M. Patient’s delay in oral cancer: a systematic review. Community Dent Oral Epidemiol. 2006;34:337–43.

    Article  Google Scholar 

  9. Noonan B. Understanding the reasons why patients delay seeking treatment for oral cancer symptoms from a primary health care professional: an integrative literature review. Eur J Oncol Nursing. 2014;18:118–24.

    Article  Google Scholar 

  10. Rath H, Shah S, Sharma G, Mishra E. Exploring determinants of care-seeking behavior of oral cancer patients in India: a qualitative content analysis. Cancer Epidemiol. 2018;53:141–8.

    Article  Google Scholar 

  11. Tonchev K, Vladimirov B. Diagnostic delay of oral squamous cell carcinoma in a cohort of Bulgarian patients. J Dent Med Sci. 2017;16:71–6.

    Google Scholar 

  12. Guizard AN, Dejardin OJ, Launay LC, et al. Diagnosis and management of head and neck cancers in a high-incidence area in France: a population-based study. Medicine (Baltimore). 2017;96:e7285.

    Article  Google Scholar 

  13. Scott SE, Grunfeld EA, McGurk M. The idiosyncratic relationship between diagnostic delay and stage of oral squamous cell carcinoma. Oral Oncol. 2005;41:396–403.

    Article  Google Scholar 

  14. Psazuwa-Peters N, Adjei Boakye E, Hussaini AS, et al. Characteristics and predictors of oral cancer knowledge in a predominantly African American community. PLoS One. 2017;12:e0177787.

    Article  Google Scholar 

  15. Reda SF, Reda SM, Thomson WM, Schwendicke F. Inequality in utilization of dental services: a systematic review and meta-analysis. Am J Public Health. 2018;108:e1–7.

    Article  Google Scholar 

  16. Holmes JD, Dierks EJ, Homer LD, Potter BE. Is detection of oral and oropharyngeal cancer by a dental health care provider associated with a lower stage at diagnosis? J Oral Maxillofac Surgf. 2003;61:285–91.

    Article  Google Scholar 

  17. Grant E, Silver K, Bauld L, et al. The experience of young oral cancer patients in Scotland: symptom recognition and delay in seeking professional help. Brit Dent J. 2010;208:465–71.

    Article  Google Scholar 

  18. Llewellyn CD, Johnson NW, Warnakulasuriya S. Factors associated with delay in presentation among younger patients with oral cancer. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;97:707–13.

    Article  Google Scholar 

  19. Warnakulasuriya S, Johnson NW, van der Waal I. Nomenclature and classification of potentially malignant disorders of the oral mucosa. J Oral Pathol Med. 2007;36:575–80.

    Article  Google Scholar 

  20. Ling H, Gadalla S, Israel E, et al. Oral Cancer exams among cigarette smokers in Maryland. Cancer Detect Prev. 2006;30:499–506.

    Article  Google Scholar 

  21. Groome PA, Rohland SL, Hall SF, et al. A population-based study of factors associated with early versus late stage oral cavity cancer diagnoses. Oral Oncol. 2011;47:642–7.

    Article  Google Scholar 

  22. Manski RJ, Brown E, Jr. Dental Procedures, United States, 1999 and 2009. AHRQ data. https://meps.ahrq.gov/data_files/publications/st368/stat368.shtml.

  23. Centers for Disease Control and Prevention, Atlanta, GA. https://www.cdc.gov/nchs/fastats/dental.htm.

  24. Burzynski NJ, Rankin KV, Silverman S Jr, et al. Graduating dental students’ perceptions of oral cancer education: results of an exit survey of seven dental schools. J Cancer Educ. 2002;17:83–4.

    PubMed  Google Scholar 

  25. Reid BC, Warren JL, Rozier G. Comorbidity and early diagnosis of head and neck cancer in a Medicare population. Am J Prev Med. 2004;27:373–8.

    Article  Google Scholar 

  26. Reid BC, Rozier RG. Continuity of care and early diagnosis of head and neck cancer. Oral Oncol. 2006;42:510–6.

    Article  Google Scholar 

  27. Onizawa K, Nishihara K, Yamagata K, et al. Factors associated with diagnostic delay of oral squamous cell carcinoma. Oral Oncol. 2003;39:781–8.

    Article  Google Scholar 

  28. Alho OP, Teppo H, Mäntyselkä P, Kantola S. Head and neck cancer in primary care: presenting symptoms and the effect of delayed diagnosis of cancer cases. CMAJ. 2006;174:779–84.

    Article  Google Scholar 

  29. Peacock ZS, Pogrel MA, Schmidt BL. Exploring the reasons for delay in treatment of oral cancer. J Am Dent Assoc. 2008;139:1346–52.

    Article  Google Scholar 

  30. Macey R, Walsh T, Brocklehurst P, et al. Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident lesions. Cochrane Database Syst Rev. 2015;29:CD010276.

    Google Scholar 

  31. Seoane J, Pablo Alvarez-Novoa P, Gomez I, et al. Early oral cancer diagnosis: The Aarhus Statement perspective. A systematic reviewand meta-analysis. Head Neck. 2016;38:E2182–9.

    Article  Google Scholar 

  32. Mundi N, Theurer J, Warner A, et al. The impact of seasonal operating room closures on wait times for oral cancer surgery. Curr Oncol. 2018;25:67–72.

    Article  Google Scholar 

  33. Polesel J, Furlan C, Birri S, et al. The impact of time to treatment initiation on survival from head and neck cancer in North-Eastern Italy. Oral Oncol. 2017;67:175–82.

    Article  Google Scholar 

  34. Dahlke S, Steinmann D, Christiansen H, et al. Impact of time factors on outcome in patients with head and neck cancer treated with definitive radio(chemo) therapy. In Vivo. 2017;31:949–55.

    PubMed  PubMed Central  Google Scholar 

  35. Ho AS, Kim S, Tighiouart M, et al. Quantitative survival impact of composite treatment delays in head and neck cancer. Cancer. 2018;124:3154.

    Article  Google Scholar 

  36. Epstein JB, Kish RV, Hallajian L, Sciubba JJ. Head and neck, oral and oropharyngeal cancer: a review of medicolegal cases. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015;119:177–86.

    Article  Google Scholar 

  37. Epstein JB, Sciubba JJ, Banasek TE, Hay LJ. Failure to diagnose and delayed diagnosis of cancer: medicolegal issues. J Am Dent Assoc. 2009;140:1494–503.

    Article  Google Scholar 

  38. Silverman S Jr, Kerr AR, Epstein JB. Oral and pharyngeal cancer control and early detection. J Cancer Educ. 2010;25:279–81.

    Article  Google Scholar 

  39. Patel Y, Bahlhom H, Zafar S, et al. Survey of Michigan dentists and radiation oncologists on oral care of patients undergoing head and neck radiation therapy. J Mich Dent Assoc. 2012;94:34–45.

    PubMed  Google Scholar 

  40. Abraham R, Anantharaman D, Gaborieau V, et al. The influence of smoking, age and stage at diagnosis on the survival after larynx, hypopharynx and oral cavity cancers in Europe: the ARCAGE study. Int J Cancer. 2018;143:32. https://doi.org/10.1002/ijc.31294 . (Epub ahead of print).

    Article  Google Scholar 

  41. Rusthoven KE, Raben D, Song JI, et al. Survival and patterns of relapse in patients with oral tongue cancer. J Oral Maxillofac Surg. 2010;68:584–9.

    Article  Google Scholar 

  42. Speight PM, Palmer S, Moles DR, et al. The cost-effectiveness of screening for oral cancer in primary care. Health Thechnol Assess. 2006;10:1–144.. iii–iv

    Google Scholar 

  43. Brocklehurst P, Kujan O, O’Maley LA, et al. Screening programmes for the early detection and prevention of oral cancer. Cochrane Database Syst Rev. 2013;19:CD004150.

    Google Scholar 

  44. Speight PM, Epstein J, Kujan O, et al. Screening for oral cancer – a perspective from the global oral cancer forum. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;123:680–7.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Dental Clinics and Residency Program, Cambridge Health Alliance, Cambridge, MA, USA

    Andrei Barasch

  2. Cedars-Sinai Health System, Los Angeles, CA, USA

    Joel B. Epstein

  3. City of Hope National Medical Center, Duarte, CA, USA

    Joel B. Epstein

Authors
  1. Andrei Barasch
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  2. Joel B. Epstein
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Corresponding author

Correspondence to Joel B. Epstein .

Editor information

Editors and Affiliations

  1. Faculty of Dentistry, Oral & Craniofacial Sciences,, King’s College London, London, UK

    Saman Warnakulasuriya

  2. Department of Orofacial Sciences, Schools of Dentistry and Medicine, University of California San Francisco, San Francisco, CA, USA

    John S. Greenspan

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Barasch, A., Epstein, J.B. (2020). Early Diagnosis of Oral Cancer. In: Warnakulasuriya, S., Greenspan, J. (eds) Textbook of Oral Cancer. Textbooks in Contemporary Dentistry. Springer, Cham. https://doi.org/10.1007/978-3-030-32316-5_15

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  • DOI: https://doi.org/10.1007/978-3-030-32316-5_15

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-32315-8

  • Online ISBN: 978-3-030-32316-5

  • eBook Packages: MedicineMedicine (R0)

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