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Malignant Transformation of Oral Potentially Malignant Disorders

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Textbook of Oral Cancer

Part of the book series: Textbooks in Contemporary Dentistry ((TECD))

Abstract

Prior to noticing any signs and symptoms of an oral squamous cell carcinoma, certain changes may be visible on the oral mucosa that are grouped under the term oral potentially malignant disorders. This concept is based on follow-up studies that have described the natural history of the disease. We present here the evidence that indicates the potentially malignant nature of these disorders.

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References

  1. Warnakulasuriya S, Johnson NW, van der Waal I. Nomenclature and classification of potentially malignant disorders of the oral mucosa. J Oral Pathol Med. 2007;36(10):575–80.

    Article  PubMed  Google Scholar 

  2. Markopoulos AK. Current aspects on oral squamous cell carcinoma. Open Dent J. 2012;6:126–30.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Reichart PA, PhilipsenH P. Oral erythroplakia--a review. Oral Oncol. 2005;41(6):551–61.

    Article  PubMed  Google Scholar 

  4. Arakeri G, Patil SG, Aljabab AS, et al. Oral submucous fibrosis: an update on pathophysiology of malignant transformation. J Oral Pathol Med. 2017;46(6):413–7.

    Article  PubMed  Google Scholar 

  5. Yang PY, Chen YT, Wang YH, Su NY, Yu HC, Chang YC. Malignant transformation of oral submucous fibrosis in Taiwan: a nationwide population-based retrospective cohort study. J Oral Pathol Med. 2017;46(10):1040–5.

    PubMed  Google Scholar 

  6. Warnakulasuriya S, Ariyawardana A. Malignant transformation of oral leukoplakia: a systematic review of observational studies. J Oral Pathol Med. 2016;45(3):155–66.

    Article  PubMed  Google Scholar 

  7. Mehanna HM, Rattay T, Smith J. McConkey. Treatment and follow-up of oral dysplasiada systematic review and meta-analysis. Head Neck. 2009;31:1600–9.

    Article  PubMed  Google Scholar 

  8. Ariyawardana A, Sitheeque MA, Ranasinghe AW, et al. Prevalence of oral cancer and pre-cancer and associated risk factors among tea estate workers in the central Sri Lanka. J Oral Pathol Med. 2007;36(10):581–7.

    Article  PubMed  Google Scholar 

  9. Amarasinghe HK, Usgodaarachchi US, Johnson NW, Lalloo R, Warnakulasuriya S. Betel-quid chewing with or without tobacco is a major risk factor for oral potentially malignant disorders in Sri Lanka: a case-control study. Oral Oncol. 2010;46(4):297–301.

    Article  PubMed  Google Scholar 

  10. Petti S. Pooled estimate of world leukoplakia prevalence: a systematic review. Oral Oncol. 2003;39(8):770–80.

    Article  PubMed  Google Scholar 

  11. World Health Organization. Definition of leukoplakia and related lesions: an aid to studies on oral precancer. Oral Surg Oral Med Oral Pathol. 1978;46(4):518–36.

    Article  Google Scholar 

  12. Axell T, Holmstrup P, Kramer IRH, Pindborg JJ, Shear M. International seminar on oral leukoplakia and associated lesions related to tobacco habits. Community Dent Oral Epidemiol. 1984;12:145–54.

    Article  Google Scholar 

  13. Axell T, Pindborg JJ, Smith CJ, der van Waal I, and an International Collaborative Group on Oral White Lesions. Oral white lesions with special reference to precancerous and tobacco-related lesions: conclusions of an international symposium held in Uppsala, Sweden, May 18–21, 1994. J Oral Pathol Med. 1996;25:49–54.

    Article  PubMed  Google Scholar 

  14. van der Waal I, Schepman KP, van der Meij EH, Smeele L. Oral leukoplakia: a clinicopathological review. Oral Oncol. 1997;33(5):291–301.

    Article  PubMed  Google Scholar 

  15. Napier SS, Speight PM. Natural history of potentially malignant oral lesions and conditions: an overview of the literature. J Oral Pathol Med. 2008;37(1):1–10.

    Article  PubMed  Google Scholar 

  16. Mehta FS, Pindborg JJ, Gupta PC, Daftary DK. Epidemiologic and histologic study of oral cancer and leukoplakia among 50,915 villagers in India. Cancer. 1969;24(4):832–49.

    Article  PubMed  Google Scholar 

  17. Arduino PG, Bagan J, El-Naggar AK, Carrozzo M. Urban legends series: oral leukoplakia. Oral Dis. 2013;19(7):642–59.

    Article  PubMed  Google Scholar 

  18. van der Waal I. Oral potentially malignant disorders: is malignant transformation predictable and preventable? Medicina Oral Patología Oral y CirugiaBucal. 2014;19:e386–90.

    Article  Google Scholar 

  19. Lee JJ, Hong WK, Hotelman WN, Mao L, et al. Predicting cancer development in oral leukoplakia: ten years of translation research. Clin Cancer Res. 2000;7:1702–10.

    Google Scholar 

  20. Einhorn J, Wersall J. Incidence of oral carcinoma in patients with leukoplakia of the oral mucosa. Cancer. 1967;20(12):2189–93.

    Article  PubMed  Google Scholar 

  21. Pindborg JJ, Jolst O, Renstrup G, Roed-Petersen B. Studies in oral leukoplakia: a preliminary report on the period pervalence of malignant transformation in leukoplakia based on a follow-up study of 248 patients. J Am Dent Assoc. 1968;76(4):767–71.

    Article  PubMed  Google Scholar 

  22. Roed-Petersen B. Cancer development in oral leukoplakia follow-up of 331 patients. J Dent Res. 1971;50:711–2.

    Google Scholar 

  23. Holmstrup P, Vedtofte P, Reibel J, Stoltze K. Long-term treatment outcome of oral premalignant lesions. Oral Oncol. 2006;42(5):461–74.

    Article  PubMed  Google Scholar 

  24. Gangadharan P, Paymaster JC. Leukoplakia- an epidemiologicstiudy of 1504 cases observed at the Tata Memorial Hospital, Bombay, India. Br J Cancer. 1971;25(4):657–68.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Silverman S, Bhargava K, Smith LW, Malaowalla AM. Malignant transformation and natural history of oral leukoplakia in 57,518 industrial workers of Gujarat, India. Cancer. 1976;38(4):1790–5.

    Article  PubMed  Google Scholar 

  26. Gupta PC, Mehta FS, Daftary DK, Pindborg JJ, et al. Incidence rates of oral cancer and natural history of oral precancerous lesions in a 10-year follow-up study of Indian villagers. Community Dent Oral Epidemiol. 1980;8(6):283–333.

    Article  PubMed  Google Scholar 

  27. Saito T, Sugiura C, Hirai A, Notani K, et al. High malignant transformation rate of widespread multiple oral leukoplakias. Oral Dis. 1999;5:15–9.

    Article  PubMed  Google Scholar 

  28. Hsue SS, Wang WC, Chen CH, et al. Malignant transformation in 1458 patients with potentially malignant oral mucosal disorders: a follow-up study based in a Taiwanese hospital. J Oral Pathol Med. 2007;36(1):25–9.

    Article  PubMed  Google Scholar 

  29. Yen AM, Chen S, Chang S, Chen TH. The effect of betel quid and cigarette on multistate progression of oral pre-malignancy. J Oral Pathol Med. 2008;37:417–22.

    Article  PubMed  Google Scholar 

  30. Liu W, Shi L-J, Wu L, et al. Oral cancer development in patients with leukoplakiaClinicopathological factors affecting outcome. PLoS One. 2012;7(4):e34773. https://doi.org/10.1371/journal.pone.0034773.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Silverman S Jr, Gorsky M, Lozada F. Oral leukoplakia and malignant transformation. A follow-up study of 257 patients. Cancer. 1984;53(3):563–8.

    Article  PubMed  Google Scholar 

  32. Napier SS, Cowan CG, Gregg TA, Stevenson M, et al. Potentially malignant oral lesions in Northern Ireland: size (extent) matters. Oral Dis. 2003;9(3):129–37.

    Article  PubMed  Google Scholar 

  33. Warnakulasuriya S, Kovacevic T, Madden P, et al. Factors predicting malignant transformation in oral potentially malignant disorders among patients accrued over a 10- year period in South East England. J Oral Pathol Med. 2011;40:677–83.

    Article  PubMed  Google Scholar 

  34. Kramer IR, El-Labban N, Lee KW. The clinical features and risk of malignant transformation in sublingual keratosis. Br Dent J. 1978;144:1721–80.

    Article  Google Scholar 

  35. Pogrel MA. Sublingual keratosis and malignant transformation. J Oral Pathol Med. 1979;8:176–8.

    Article  Google Scholar 

  36. Roch-Berry CSB. Malignant changes in glossal leukoplakia. Clin Radiol. 1981;32:693–4.

    Article  PubMed  Google Scholar 

  37. Ho MW, Risk JM, Woolgar JA, et al. Clinical determinants of malignant transformation in oral epithelial dysplasia. Oral Oncol. 2012;48:969–76.

    Article  PubMed  Google Scholar 

  38. Bánóczy J. Follow-up studies in oral leukoplakia. J Maxillofac Surg. 1977;5:69–75.

    Article  PubMed  Google Scholar 

  39. Lind PO. Malignant transformation in oral leukoplakia. Scand J Dent Res. 1987;95(6):449–55.

    PubMed  Google Scholar 

  40. Hogewind WFC, can der Kwast WAM, van der Wall I. Oral leukoplakia, with emphasis on malignant transformation. J Maxillofac Surg. 1989;17:128–33.

    Google Scholar 

  41. Schepman KP, van der Meij EH, Smeele LE, van der Wall I. Malignant transformation of oral leukoplakia: a follow-up study of a hospital based population of 166 patients with leukoplakia from the Netherlands. Oral Oncol. 1998;34:270–5.

    Article  PubMed  Google Scholar 

  42. Brouns E, Baart J, Karagozoglu K, et al. Malignant transformation of oral leukoplakia in a well-defined cohort of 144 patients. Oral Dis. 2014;20(3):e19–24.

    Article  PubMed  Google Scholar 

  43. Arduino PG, Surace A, Carbone M, et al. Outcome of oral dysplasia: a retrospective hospital-based study of 207 patients with a long follow-up. J Oral Pathol Med. 2009;38:540–4.

    Article  PubMed  Google Scholar 

  44. Brzak BL, Mravak-Stipeti CM, Canjuga I, et al. The frequency and malignanttransformation rate of oral lichen planus and leukoplakia-A retrospective study. Coll Anthropol. 2012;36:373–7.

    Google Scholar 

  45. Lyu MY, Guo YS, Li S, Yang D, Hua H. Hospital-based epidemiological and clinical characterisation of the malignant transformation of oral leukoplakia in a Chinese population. Int Dent J. 2017;67(4):252–9.

    Article  PubMed  Google Scholar 

  46. Castelo-Branco C, Soveral I. The immune system and aging: a review. Gynecol Endocrinol. 2014;30(1):16–22.

    Article  PubMed  Google Scholar 

  47. El Naggar AK, Reichart PA. Proliferative verrucous leukoplakia and precancerous conditions. In: Barnes L, Eveson JW, Reichart P, Sidransky D, editors. Pathology and genetics of head and neck tumours. Lyon: International Agency for Research on Cancer (IARC), IARC Press; 2005.

    Google Scholar 

  48. Bagan J, Scully C, Jimenez Y, Martorell M. Proliferative verrucous leukoplakia: a concise update. Oral Dis. 2010;16(4):328–32.

    Article  PubMed  Google Scholar 

  49. Zakrzewska JM, Lopes V, Speight P, Hopper C. Proliferative verrucous leukoplakia: a report of ten cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996;82(4):396–401.

    Article  PubMed  Google Scholar 

  50. Silverman S Jr, Gorsky M. Proliferative verrucous leukoplakia: a follow-up study of 54 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997;84(2):154–7.

    Article  PubMed  Google Scholar 

  51. Bagan JV, Jimenez-Soriano Y, Diaz-Fernandez JM, et al. Malignant transformation of proliferative verrucous leukoplakia to oral squamous cell carcinoma: a series of 55 cases. Oral Oncol. 2011;47(8):732–5.

    Article  PubMed  Google Scholar 

  52. Capellaa DL, Goncalves JM, Abrantes AAA, Grando LJ, Daniel FI. Proliferative verrucous leukoplakia: diagnosis, management and current advances. Braz J Otorhinolaryngol. 2017;83(5):585–93.

    Article  Google Scholar 

  53. Gale N, Pilch BZ, Sidransky D, Westra WH, Califano J. Epithelial precursor lesions. In: Barnes L, Eveson JW, Reichart P, Sidransky D, editors. World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. Lyon: IARC Press; 2005. p. 140–3.

    Google Scholar 

  54. Villa A, Villa C, Abati S. Oral cancer and oral erythroplakia: an update and implication for clinicians. Aust Dent J. 2011;56(3):253–6.

    Article  PubMed  Google Scholar 

  55. Arakeri G, Brennan PA. Oral submucous fibrosis: an overview of the aetiology, pathogenesis, classification, and principles of management. Br J Oral Maxillofac Surg. 2013;51(7):587–93.

    Article  PubMed  Google Scholar 

  56. Tilakaratne WM, EkanayakaR P, Warnakulasuriya S. Oral submucous fibrosis: a historical perspective and a review on etiology and pathogenesis. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;122(2):178–91.

    Article  PubMed  Google Scholar 

  57. Aziz SR. Oral submucous fibrosis: case report and review of diagnosis and treatment. J Oral Maxillofac Surg. 2008;66(11):2386–9.

    Article  PubMed  Google Scholar 

  58. Sukumar S, ColemanH G, Cox SC. Areca nut chewing in an expatriate population in Sydney: report of two cases. Aust Dent J. 2012;57(3):373–8.

    Article  PubMed  Google Scholar 

  59. Cox SC, WalkerD M. Oral submucous fibrosis. A review. Aust Dent J. 1996;41(5):294–9.

    Article  PubMed  Google Scholar 

  60. Yang S-F, Wang Y-H, Su N-Y, Yu H-C, Yi WC, Yu C-H, Chang Y-C. Changes in prevalence of precancerous oral submucous fibrosis from 1996 to 2013 in Taiwan: a nationwide population-based retrospective study. J Formos Med Assoc. 2017; https://doi.org/10.1016/j.jfma.2017.01.012.

    Article  PubMed  Google Scholar 

  61. Paymaster JC. Cancer of the buccal mucosa; a clinical study of 650 cases in Indian patients. Cancer. 1956;9:431–5.

    Article  PubMed  Google Scholar 

  62. International Agency for Research on Cancer WHO. IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans. Betel-quid and areca-nut chewing and somr areca-nut derived nitrosamines, vol. 85. Lyon: IARC; 2004.

    Google Scholar 

  63. Ariyawardana A, Athukorala AD, Arulanandam A. Effect of betel chewing, tobacco smoking and alcohol consumption on oral submucous fibrosis: a case-control study in Sri Lanka. J Oral Pathol Med. 2006;35(4):197–201.

    Article  PubMed  Google Scholar 

  64. Ho PS, Yang YH, Shieh TY, et al. Consumption of areca quid, cigarettes, and alcohol related to the comorbidity of oral submucous fibrosis and oral cancer. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;104(5):647–52.

    Article  PubMed  Google Scholar 

  65. Pindborg JJ, Murti PR, Bhonsle RB, Gupta PC, Daftary DK, Mehta FS. Oral submucous fibrosis as a precancerous condition. Scand J Dent Res. 1984;92(3):224–9.

    PubMed  Google Scholar 

  66. Murti PR, Bhonsle RB, Pindborg JJ, Daftary DK, Gupta PC, Mehta FS. Malignant transformation rate in oral submucous fibrosis over a 17-year period. Community Dent Oral Epidemiol. 1985;13(6):340–1.

    Article  PubMed  Google Scholar 

  67. Hazarey VK, Erlewad DM, Mundhe KA, Ughade SN. Oral submucous fibrosis: study of 1000 cases from central India. J Oral Pathol Med. 2007;36(1):12–7.

    Article  PubMed  Google Scholar 

  68. Tang JG, Jian XF, Gao ML, Ling TY, Zhang KH. Epidemiological survey of oral submucous fibrosis in Xiangtan City, Hunan Province, China. Community Dent Oral Epidemiol. 1997;25(2):177–80.

    Article  PubMed  Google Scholar 

  69. Wang YY, Tail YH, Wang WC. Malignant transformation in 5071 southern Taiwanese patients with potentially malignant oral mucosal disorders. BMC Oral Health. 2014;14:99.

    Article  PubMed  PubMed Central  Google Scholar 

  70. LianIe B, Tseng YT, Su CC, Tsai KY. Progression of precancerous lesions to oral cancer: results based on the Taiwan National Health Insurance Database. Oral Oncol. 2013;49(5):427–30.

    Article  Google Scholar 

  71. Sinor PN, Gupta PC, Murti PR. A case-control study of oral submucous fibrosis with special reference to the etiologic role of areca nut. J Oral Pathol Med. 1990;19(2):94–8.

    Article  PubMed  Google Scholar 

  72. Shah N, Sharma PP. Role of chewing and smoking habits in the etiology of oral submucous fibrosis (OSF): a case-control study. J Oral Pathol Med. 1998;27(10):475–9.

    Article  PubMed  Google Scholar 

  73. McCartan BE, Healy CM. The reported prevalence of oral lichen planus: a review and critique. J Oral Pathol Med. 2008;37(8):447–53.

    Article  PubMed  Google Scholar 

  74. Gonzalez-Moles MA, Scully C, Gil-Montoya JA. Oral lichen planus: controversies surrounding malignant transformation. Oral Dis. 2008;14(3):229–43.

    Article  PubMed  Google Scholar 

  75. Roopashree MR, Gondhalekar RV, Shashikanth MC, George J, Thippeswamy SH, Shukla A. Pathogenesis of oral lichen planus--a review. J Oral Pathol Med. 2010;39(10):729–34.

    Article  PubMed  Google Scholar 

  76. Otero-Rey EM, Suarez-Alen F, Penamaria-Mallon M, Lopez-Lopez J, Blanco-Carrion A. Malignant transformation of oral lichen planus by a chronic inflammatory process. Use of topical corticosteroids to prevent this progression? Acta Odontol Scand. 2014;72(8):570–7.

    Article  PubMed  Google Scholar 

  77. Krutchkoff DJ, Cutler L, Laskowski S. Oral lichen planus: the evidence regarding potential malignant transformation. J Oral Pathol. 1978;7(1):1–7.

    Article  PubMed  Google Scholar 

  78. van der Meij EH, Schepman KP, Smeele LE, van der Wal JE, Bezemer PD, van der Waal I. A review of the recent literature regarding malignant transformation of oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999;88(3):307–10.

    Article  PubMed  Google Scholar 

  79. Fitzpatrick SG, HirschS A, GordonS C. The malignant transformation of oral lichen planus and oral lichenoid lesions: a systematic review. J Am Dent Assoc. 2014;145(1):45–56.

    Article  PubMed  Google Scholar 

  80. van der Meij EH, Mast H, van der Waal I. The possible premalignant character of oral lichen planus and oral lichenoid lesions: a prospective five-year follow-up study of 192 patients. Oral Oncol. 2007;43(8):742–8.

    Article  PubMed  Google Scholar 

  81. van der Meij EH, van der Waal I. Lack of clinicopathologic correlation in the diagnosis of oral lichen planus based on the presently available diagnostic criteria and suggestions for modifications. J Oral Pathol Med. 2003;32(9):507–12.

    Article  PubMed  Google Scholar 

  82. Aghbari SMH, Abushouk AI, Attia A, et al. Malignant transformation of oral lichen planus and oral lichenoid lesions: a meta-analysis of 20095 patient data. Oral Oncol. 2017;68:92–102.

    Article  PubMed  Google Scholar 

  83. Mignogna MD, Fedele S, Lo Russo L, Mignogna C, de Rosa G, Porter SR. Field cancerization in oral lichen planus. Eur J Surg Oncol. 2007;33(3):383–9.

    Article  PubMed  Google Scholar 

  84. Carrozzo M, Quadri R, Latorre P, et al. Molecular evidence that the hepatitis C virus replicates in the oral mucosa. J Hepatol. 2002;37(3):364–9.

    Article  PubMed  Google Scholar 

  85. Nagao Y, Sata M, Tanikawa K, Itoh K, Kameyama T. High prevalence of hepatitis C virus antibody and RNA in patients with oral cancer. J Oral Pathol Med. 1995;24(8):354–60.

    Article  PubMed  Google Scholar 

  86. Cavalcante AS, AnbinderA L, CarvalhoY R. Actinic cheilitis: clinical and histological features. J Oral Maxillofac Surg. 2008;66(3):498–503.

    Article  PubMed  Google Scholar 

  87. Markopoulos A, Albanidou-Farmaki E, Kayavis I. Actinic cheilitis: clinical and pathologic characteristics in 65 cases. Oral Dis. 2004;10(4):212–6.

    Article  PubMed  Google Scholar 

  88. de Santana Sarmento DJ, da Costa Miguel MC, Queiroz LM, Godoy GP, da Silveira EJ. Actinic cheilitis: clinicopathologic profile and association with degree of dysplasia. Int J Dermatol. 2014;53(4):466–72.

    Article  PubMed  Google Scholar 

  89. Dancyger A, Heard V, Huang B, Suley C, Tang D, Ariyawardana A. Malignant transformation of actinic cheilitis: a systematic review of observational studies. J Clin Invest Dent. 2018. In press

    Google Scholar 

  90. de Oliveira Ribeiro A, da SilvaL C, Martins-Filho PR. Prevalence of and risk factors for actinic cheilitis in Brazilian fishermen and women. Int J Dermatol. 2014;53(11):1370–6.

    Article  PubMed  Google Scholar 

  91. Wood NH, Khammissa R, Meyerov R, Lemmer J, Feller L. Actinic Cheilitis: a case report and a review of the literature. Eur J Dent. 2011;5(1):101–6.

    PubMed  PubMed Central  Google Scholar 

  92. Ortiz GM, PierceA M, Wilson DF. Palatal changes associated with reverse smoking in Filipino women. Oral Dis. 1996;2(3):232–7.

    Article  PubMed  Google Scholar 

  93. Pindborg JJ, Mehta FS, Gupta PC, Daftary DK, Smith CJ. Reverse smoking in Andhra Pradesh, India: a study of palatal lesions among 10,169 villagers. Br J Cancer. 1971;25(1):10–20.

    Article  PubMed  PubMed Central  Google Scholar 

  94. Bharath TS, Kumar NG, Nagaraja A, Saraswathi TR, Babu GS, Raju PR. Palatal changes of reverse smokers in a rural coastal Andhra population with review of literature. J Oral Maxillofac Pathol. 2015;19(2):182–7.

    Article  PubMed  PubMed Central  Google Scholar 

  95. Neville BW, Damm DD, Allen CM, Bouquot JE. Oral and maxillofacial pathology. 4th ed: Elsevier; Saunders; 2016.

    Google Scholar 

  96. van der Eb MM, Leyten EM, Gavarasana S, Vandenbroucke JP, Kahn PM, Cleton FJ. Reverse smoking as a risk factor for palatal cancer: a cross-sectional study in rural Andhra Pradesh, India. Int J Cancer. 1993;54(5):754–8.

    Article  PubMed  Google Scholar 

  97. Morrow RC, Suarez G. Mucosal changes and cancer in intra-oral smoking. Laryngoscope. 1971;81(7):1020–8.

    Article  PubMed  Google Scholar 

  98. Liu W, Shen ZY, Wang LJ, et al. Malignant potential of oral and labial chronic discoid lupus erythematosus: a clinicopathological study of 87 cases. Histopathology. 2011;59(2):292–8.

    Article  PubMed  Google Scholar 

  99. Handlers JP, Abrams AM, Aberle AM, Auyong T, Melrose RJ. Squamous cell carcinoma of the lip developing in discoid lupus erythematosus. Oral Surg Oral Med Oral Pathol. 1985;60(4):382–6.

    Article  PubMed  Google Scholar 

  100. Schiodt M. Oral discoid lupus erythematosus. III. A histopathologic study of sixty-six patients. Oral Surg Oral Med Oral Pathol. 1984;57(3):281–93.

    Article  PubMed  Google Scholar 

  101. Noto Z, Tomihara K, Furukawa K, Noguchi M. Dyskeratosiscongenita associated with leukoplakia of the tongue. Int J Oral Maxillofac Surg. 2016;45(6):760–3.

    Article  PubMed  Google Scholar 

  102. Handley TP, McCaul JA, Ogden GR. Dyskeratosis congenita. Oral Oncol. 2006;42(4):331–6.

    Article  PubMed  Google Scholar 

  103. Pinna R, Cocco F, Cagetti MG, Conti G, Milia E, Sardella A, Campus G. Genetic and developmental disorders of the oral mucosa: epidemiology; molecular mechanisms; diagnostic criteria, management. Periodontol. 2000;2018. in press

    Google Scholar 

  104. Bongiorno M, Rivard S, Hammer D, Kentosh J. Malignant transformation of oral leukoplakia in a patient with dyskeratosis congenita. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;124(4):e239–42.

    Article  PubMed  Google Scholar 

  105. Alter BP, Giri N, Savage SA, Rosenberg PS. Cancer in dyskeratosis congenita. Blood. 2009;113(26):6549–57.

    Article  PubMed  PubMed Central  Google Scholar 

  106. Bandyopadhyay A, Behura SS, Nishat R, Dash KC, Bhuyan L, Ramachandra S. Clinicopathological profile and malignant transformation in oral lichen planus: a retrospective study. J Int Soc Prev Community Dent. 2017;7(3):116–24.

    PubMed  PubMed Central  Google Scholar 

  107. Irani S. Pre-cancerous lesions in the oral and maxillofacial region: a literature review with special focus on etiopathogenesis. Iran J Pathol. 2016;11(4):303–22.

    PubMed  PubMed Central  Google Scholar 

  108. Lauritano D, Arrica M, Lucchese A, et al. Oral lichen planus clinical characteristics in Italian patients: a retrospective analysis. Head Face Med. 2016;12:18.

    Article  PubMed  PubMed Central  Google Scholar 

  109. Varghese SS, George GB, Sarojini SB, et al. Epidemiology of oral lichen planus in a cohort of South Indian population: a retrospective study. J Cancer Prev. 2016;21(1):55–9.

    Article  PubMed  PubMed Central  Google Scholar 

  110. Richter I, Andabak-Rogulj A, Vučićević-Boras V, Budimir J, Brailo V. Oral lichen planus–retrospective study of 563 Croatian patients. Medicina oral, patologia oral y cirugia Bucal. 2014;19(3):e255.

    PubMed  PubMed Central  Google Scholar 

  111. Radochová V, Dřízhal I, Slezák R. A retrospective study of 171 patients with oral lichen planus in the East Bohemia-Czech Republic–single center experience. J Clin Exp Dent. 2014;6(5):e556.

    Article  PubMed  PubMed Central  Google Scholar 

  112. Bardellini E, Amadori F, Flocchini P, Bonadeo S, Majorana A. Clinicopathological features and malignant transformation of oral lichen planus: a 12-years retrospective study. Acta Odontol Scand. 2013;71(3–4):834–40.

    Article  PubMed  Google Scholar 

  113. Gumru B. A retrospective study of 370 patients with oral lichen planus in Turkey. Med Oral Patol Oral Cir Bucal. 2013;18(3):e427–32.

    Article  PubMed  PubMed Central  Google Scholar 

  114. Ilana K, Yael V-S, Gavriel G, Shlomo C, Anavi Y. The dynamics of oral lichen planus: a retrospective clinicopathological study. Head Neck Pathol. 2012;6:178–83.

    Article  Google Scholar 

  115. Shen Zheng Yu LW, Zhu Lai Kuan, Feng Jin Qiu, Tang Guo Yao, Zhou ZT. A retrospective clinicopathological study on oral lichen planus and malignant transformation: analysis of 518 cases. Medicina oral, patologia oral y cirugia Bucal. 2012;17:943–7.

    Article  Google Scholar 

  116. Bombeccari GP, Guzzi G, Tettamanti M, et al. Oral lichen planus and malignant transformation: a longitudinal cohort study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;112(3):328–34.

    Article  PubMed  Google Scholar 

  117. Bermejo-Fenoll A, Sánchez-Siles M, López-Jornet P, Camacho-Alonso F, Salazar-Sánchez N. A retrospective clinicopathological study of 550 patients with oral lichen planus in South-Eastern Spain. J Oral Pathol Med. 2010;39(6):491–6.

    Article  PubMed  Google Scholar 

  118. Torrente-Castells Eulàlia FR, Leonardo B-A, Cosme G-E. Clinical features of oral lichen planus. A retrospective study of 65cases. Med Oral Patol Oral Cir Bucal. 2010;15:e685–90.

    Article  PubMed  Google Scholar 

  119. Carbone M, Arduino PG, Carrozzo M, et al. Course of oral lichen planus: a retrospective study of 808 northern Italian patients. Oral Dis. 2009;15(3):235–43.

    Article  PubMed  Google Scholar 

  120. Xue JL, Fan MW, Wang SZ, Chen XM, Li Y, Wang L. A clinical study of 674 patients with oral lichen planus in China. J Oral Pathol Med. 2005;34(8):467–72.

    Article  PubMed  Google Scholar 

  121. van der Meij, Mast EH, van der Waal I. The possible premalignant character of oral lichen planus and oral lichenoid lesions: a prospective study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;96(2):164–71.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. College of Medicine and Dentistry, Cairns Campus, James Cook University, Cairns, QLD, Australia

    Anura Ariyawardana

  2. Metro South Oral Health, Wooloongabba, QLD, Australia

    Anura Ariyawardana

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  1. Anura Ariyawardana
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Correspondence to Anura Ariyawardana .

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  1. Faculty of Dentistry, Oral & Craniofacial Sciences,, King’s College London, London, UK

    Saman Warnakulasuriya

  2. Department of Orofacial Sciences, Schools of Dentistry and Medicine, University of California San Francisco, San Francisco, CA, USA

    John S. Greenspan

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Ariyawardana, A. (2020). Malignant Transformation of Oral Potentially Malignant Disorders. In: Warnakulasuriya, S., Greenspan, J. (eds) Textbook of Oral Cancer. Textbooks in Contemporary Dentistry. Springer, Cham. https://doi.org/10.1007/978-3-030-32316-5_13

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  • DOI: https://doi.org/10.1007/978-3-030-32316-5_13

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