Abstract
Accurate and automatic analysis of breast MRI plays a vital role in early diagnosis and successful treatment planning for breast cancer. Due to the heterogeneity nature, precise diagnosis of tumors remains a challenging task. In this paper, we propose to identify breast tumor in MRI by Cosine Margin Sigmoid Loss (CMSL) with deep learning (DL) and localize possible cancer lesion by COrrelation Attention Map (COAM) based on the learned features. The CMSL embeds tumor features onto a hyper-sphere and imposes a decision margin through cosine constraints. In this way, the DL model could learn more separable inter-class features and more compact intra-class features in the angular space. Furthermore, we utilize the correlations among feature vectors to generate attention maps that could accurately localize cancer candidates with only image-level labels. We build the largest breast cancer dataset involving 10,290 DCE-MRI scan volumes for developing and evaluating the proposed methods. The model driven by CMSL achieved a classification accuracy of 0.855 and AUC of 0.902 on the testing set, with sensitivity and specificity of 0.857 and 0.852, respectively, outperforming competitive methods overall. In addition, the proposed COAM accomplished more accurate localization of the cancer center compared with other state-of-the-art weakly supervised localization method.
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Acknowledgement
This work was supported by Research Grants Council of Hong Kong Special Administrative Region under Project No. CUHK14225616 and Hong Kong Innovation and Technology Fund under Project No. ITS/426/17FP.
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Luo, L. et al. (2019). Deep Angular Embedding and Feature Correlation Attention for Breast MRI Cancer Analysis. In: Shen, D., et al. Medical Image Computing and Computer Assisted Intervention – MICCAI 2019. MICCAI 2019. Lecture Notes in Computer Science(), vol 11767. Springer, Cham. https://doi.org/10.1007/978-3-030-32251-9_55
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DOI: https://doi.org/10.1007/978-3-030-32251-9_55
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