Abstract
Most existing methods handle cell instance segmentation problems directly without relying on additional detection boxes. These methods generally fails to separate touching cells due to the lack of global understanding of the objects. In contrast, box-based instance segmentation solves this problem by combining object detection with segmentation. However, existing methods typically utilize anchor box-based detectors, which would lead to inferior instance segmentation performance due to the class imbalance issue. In this paper, we propose a new box-based cell instance segmentation method. In particular, we first detect the five pre-defined points of a cell via keypoints detection. Then we group these points according to a keypoint graph and subsequently extract the bounding box for each cell. Finally, cell segmentation is performed on feature maps within the bounding boxes. We validate our method on two cell datasets with distinct object shapes, and empirically demonstrate the superiority of our method compared to other instance segmentation techniques. Code is available at: https://github.com/yijingru/KG_Instance_Segmentation.
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References
Chen, H., Qi, X., Yu, L., Heng, P.A.: DCAN: deep contour-aware networks for accurate gland segmentation. In: CVPR, pp. 2487–2496 (2016)
Everingham, M., Van Gool, L., Williams, C.K., Winn, J., Zisserman, A.: The PASCAL visual object classes (VOC) challenge. IJCV 88(2), 303–338 (2010)
He, K., Gkioxari, G., Dollár, P., Girshick, R.: Mask R-CNN. In: ICCV, pp. 2961–2969 (2017)
He, K., Zhang, X., Ren, S., Sun, J.: Deep residual learning for image recognition. In: CVPR, pp. 770–778 (2016)
Law, H., Deng, J.: CornerNet: detecting objects as paired keypoints. In: Ferrari, V., Hebert, M., Sminchisescu, C., Weiss, Y. (eds.) Computer Vision – ECCV 2018. LNCS, vol. 11218, pp. 765–781. Springer, Cham (2018). https://doi.org/10.1007/978-3-030-01264-9_45
Li, Y., Qi, H., Dai, J., Ji, X., Wei, Y.: Fully convolutional instance-aware semantic segmentation. In: CVPR, pp. 2359–2367 (2017)
Newell, A., Yang, K., Deng, J.: Stacked hourglass networks for human pose estimation. In: Leibe, B., Matas, J., Sebe, N., Welling, M. (eds.) ECCV 2016. LNCS, vol. 9912, pp. 483–499. Springer, Cham (2016). https://doi.org/10.1007/978-3-319-46484-8_29
Papandreou, G., Zhu, T., Chen, L.-C., Gidaris, S., Tompson, J., Murphy, K.: PersonLab: person pose estimation and instance segmentation with a bottom-up, part-based, geometric embedding model. In: Ferrari, V., Hebert, M., Sminchisescu, C., Weiss, Y. (eds.) Computer Vision – ECCV 2018. LNCS, vol. 11218, pp. 282–299. Springer, Cham (2018). https://doi.org/10.1007/978-3-030-01264-9_17
Payer, C., Štern, D., Neff, T., Bischof, H., Urschler, M.: Instance segmentation and tracking with cosine embeddings and recurrent hourglass networks. In: Frangi, A.F., Schnabel, J.A., Davatzikos, C., Alberola-López, C., Fichtinger, G. (eds.) MICCAI 2018. LNCS, vol. 11071, pp. 3–11. Springer, Cham (2018). https://doi.org/10.1007/978-3-030-00934-2_1
Ronneberger, O., Fischer, P., Brox, T.: U-Net: convolutional networks for biomedical image segmentation. In: Navab, N., Hornegger, J., Wells, W.M., Frangi, A.F. (eds.) MICCAI 2015. LNCS, vol. 9351, pp. 234–241. Springer, Cham (2015). https://doi.org/10.1007/978-3-319-24574-4_28
Schmidt, U., Weigert, M., Broaddus, C., Myers, G.: Cell detection with star-convex polygons. In: Frangi, A.F., Schnabel, J.A., Davatzikos, C., Alberola-López, C., Fichtinger, G. (eds.) MICCAI 2018. LNCS, vol. 11071, pp. 265–273. Springer, Cham (2018). https://doi.org/10.1007/978-3-030-00934-2_30
Yi, J., Wu, P., Jiang, M., Huang, Q., Hoeppner, D.J., Metaxas, D.N.: Attentive neural cell instance segmentation. Med. Image Anal. 55, 228–240 (2019)
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Yi, J. et al. (2019). Multi-scale Cell Instance Segmentation with Keypoint Graph Based Bounding Boxes. In: Shen, D., et al. Medical Image Computing and Computer Assisted Intervention – MICCAI 2019. MICCAI 2019. Lecture Notes in Computer Science(), vol 11764. Springer, Cham. https://doi.org/10.1007/978-3-030-32239-7_41
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DOI: https://doi.org/10.1007/978-3-030-32239-7_41
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