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Major Subtypes of Mature T- and NK-Cell Neoplasms

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Practical Lymph Node and Bone Marrow Pathology

Part of the book series: Practical Anatomic Pathology ((PAP))

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Abstract

This chapter is focused on answering frequently asked questions in the workup of the most common T-cell and NK-cell neoplasms. Since cutaneous T-cell lymphomas and T-cell lymphomas of the intestine are expanded upon elsewhere, this text primarily involves the morphologic, immunophenotypic, and molecular evaluation of nodal, leukemic, and a few extranodal entities. While T- and NK-cell lymphomas are relatively rare, within this umbrella, angioimmunoblastic T-cell lymphoma, anaplastic large cell lymphoma, and peripheral T-cell lymphoma, not otherwise specified, are still encountered and regularly suspected in a general surgical pathologist’s busy practice. These are also areas in which some alterations to the classification have occurred over the last few years. We summarize the key points here and how they apply to the clinical workup of these neoplasms.

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References

  1. Swerdlow SH, Campo E, Harris N, Jaffe E, Pileri S, Stein H, et al. WHO classification of tumours of haematopoietic and lymphoid tissues. In: World Health Organization classification of tumours. Lyon, France: IARC. p. 2017.

    Google Scholar 

  2. Hsi ED. Peripheral T-cell lymphomas. In: Hematopathology. 3rd ed. Elsevier; 2018. p. 306–39.

    Google Scholar 

  3. Hsi ED. Mature T-cell and natural killer–cell leukemias. In: Hematopathology. 3rd ed. Philadelphia: Elsevier; 2018. p. 414–28.

    Google Scholar 

  4. Bal M, Gujral S, Gandhi J, Shet T, Epari S, Subramanian PG. Angioimmunoblastic T-cell lymphoma: a critical analysis of clinical, morphologic and immunophenotypic features. Indian J Pathol Microbiol. 2010;53(4):640–5.

    Google Scholar 

  5. Kinney MC, Higgins RA, Medina EA. Anaplastic large cell lymphoma: twenty-five years of discovery. Arch Pathol Lab Med. 2011;135(1):19–43.

    Article  Google Scholar 

  6. Qayyum S, Choi JK. Adult T-cell leukemia/lymphoma. Arch Pathol Lab Med. 2014;138(2):282–6.

    Article  CAS  Google Scholar 

  7. Gill H, Liang RHS, Tse E. Extranodal natural-killer/T-cell lymphoma, nasal type. Adv Hematol. 2010;2010:627401.

    Google Scholar 

  8. Yang S, Wang E. Hepatosplenic T-cell lymphoma: a clinicopathologic review with an emphasis on diagnostic differentiation from other T-cell/natural killer–cell neoplasms. Arch Pathol Lab Med. 2015;139(9):1173–80.

    Article  Google Scholar 

  9. Parveen Z, Thompson K. Subcutaneous panniculitis-like T-cell lymphoma: redefinition of diagnostic criteria in the recent World Health Organization-European Organization for Research and Treatment of Cancer classification for cutaneous lymphomas. Arch Pathol Lab Med. 2009;133(2):303–8.

    Google Scholar 

  10. Chen X, Cherian S. Immunophenotypic characterization of T-cell prolymphocytic leukemia. Am J Clin Pathol. 2013;140(5, 1):727–35.

    Article  Google Scholar 

  11. Arps DP, Smith LB. Classic versus type II enteropathy-associated T-cell lymphoma: diagnostic considerations. Arch Pathol Lab Med. 2013;137(9):1227–31.

    Google Scholar 

  12. Attygalle AD, Cabeçadas J, Gaulard P, Jaffe ES, de Jong D, Ko YH, et al. Peripheral T-cell and NK-cell lymphomas and their mimics; taking a step forward - report on the lymphoma workshop of the XVIth meeting of the European Association for Haematopathology and the Society for Hematopathology. Histopathology. 2014;64(2):171–99.

    Google Scholar 

  13. Moroch J, Copie-Bergman C, de Leval L, Plonquet A, Martin-Garcia N, Delfau-Larue MH, et al. Follicular peripheral T-cell lymphoma expands the spectrum of classical Hodgkin lymphoma mimics. Am J Surg Pathol. 2012;36(11):1636–46.

    Google Scholar 

  14. Wang CY, Yu PF, He XB, Fang YX, Cheng WY, Jing ZZ. αβ T-cell receptor bias in disease and therapy (review). Int J Oncol. 2016;48(6):2247–56.

    Google Scholar 

  15. Fitzgerald JE, Ricalton NS, Meyer AC, West SG, Kaplan H, Behrendt C, et al. Analysis of clonal CD8+ T cell expansions in normal individuals and patients with rheumatoid arthritis. J Immunol. 1995;154(7):3538–47.

    Google Scholar 

  16. Raess PW, Bagg A. The role of molecular pathology in the diagnosis of cutaneous lymphomas. Pathol Res Int. 2012;2012:913523.

    Article  Google Scholar 

  17. Hsi ED, Said J, Macon WR, Rodig SJ, Ondrejka SL, Gascoyne RD, et al. Diagnostic accuracy of a defined immunophenotypic and molecular genetic approach for peripheral T/NK-cell lymphomas: a North American PTCL Study Group Project. Am J Surg Pathol. 2014;38(6):768–75.

    Google Scholar 

  18. Parrilla Castellar ER, Jaffe ES, Said JW, Swerdlow SH, Ketterling RP, Knudson RA, et al. ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes. Blood. 2014;124(9):1473–80.

    Google Scholar 

  19. Wang X, Boddicker RL, Dasari S, Sidhu JS, Kadin ME, Macon WR, et al. Expression of p63 protein in anaplastic large cell lymphoma: implications for genetic subtyping. Hum Pathol. 2017;64:19–27.

    Google Scholar 

  20. Zaki MA, Wada N, Kohara M, Ikeda J, Hori Y, Fujita S, et al. Presence of B-cell clones in T-cell lymphoma. Eur J Haematol. 2011;86(5):412–9.

    Google Scholar 

  21. Vose J, Armitage J, Weisenburger D. International T-cell lymphoma project. International peripheral T-cell and natural killer/T-cell lymphoma study: pathology findings and clinical outcomes. J Clin Oncol. 2008;26(25):4124–30.

    Article  Google Scholar 

  22. Savage KJ, Harris NL, Vose JM, Ullrich F, Jaffe ES, Connors JM, et al. ALK- anaplastic large cell lymphoma is clinically and immunophenotypically different from both ALK+ ALCL and peripheral T-cell lymphoma not otherwise specified: report from the International Peripheral T-cell Lymphoma Project. Blood. 2008;111:5496–504.

    Google Scholar 

  23. Yong W. Clinical study of l-asparaginase in the treatment of extranodal NK/T-cell lymphoma, nasal type. Hematol Oncol. 2016;34(2):61–8.

    Article  CAS  Google Scholar 

  24. Moskowitz AJ, Lunning MA, Horwitz SM. How I treat the peripheral T-cell lymphomas. Blood. 2014;123(17):2636–44.

    Article  CAS  Google Scholar 

  25. d’Amore F, Gaulard P, Trümper L, Corradini P, Kim WS, Specht L, et al. ESMO Guidelines Committee. Peripheral T-cell lymphomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2015;26(Suppl 5):v108–15.

    Article  Google Scholar 

  26. Rahemtullah A, Reichard KK, Preffer FI, Harris NL, Hasserjian RP. A double-positive CD4+ CD8+ T-cell population is commonly found in Nodular Lymphocyte Predominant Hodgkin Lymphoma. Am J Clin Pathol. 2006;126:805–14.

    Google Scholar 

  27. Herrera AF, Crosby-Thompson A, Friedberg JW. Comparison of referring and final pathology for patients with T-cell lymphoma in the National Comprehensive Cancer Network. Cancer. 2014;120(13):1993–9.

    Article  Google Scholar 

  28. Laurent C, Baron M, Amara N, Haioun C, Dandoit M, Maynadié M, et al. Impact of expert pathologic review of lymphoma diagnosis: study of patients from the French Lymphopath Network. J Clin Oncol. 2017;35(18):2008–17.

    Google Scholar 

  29. Bellei M, Sabattini E, Pesce EA, Ko YH, Kim WS, Cabrera ME, et al. Pitfalls and major issues in the histologic diagnosis of peripheral T-cell lymphomas: results of the central review of 573 cases from the T-cell Project, an international cooperative study. Hematol Oncol. 2017;35:630–6.

    Google Scholar 

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Author Disclosures

Neither LI nor MLX have conflicts of interest.

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Authors and Affiliations

  1. Departments of Pathology and Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA

    Lina Irshaid & Mina L. Xu

Authors
  1. Lina Irshaid
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  2. Mina L. Xu
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Corresponding author

Correspondence to Mina L. Xu .

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Editors and Affiliations

  1. Department of Pathology, Duke University School of Medicine and Duke Health System, Durham, NC, USA

    Endi Wang

  2. Department of Pathology, Duke University School of Medicine and Duke Health System, Durham, NC, USA

    Anand Shreeram Lagoo

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Irshaid, L., Xu, M.L. (2020). Major Subtypes of Mature T- and NK-Cell Neoplasms. In: Wang, E., Lagoo, A.S. (eds) Practical Lymph Node and Bone Marrow Pathology. Practical Anatomic Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-32189-5_8

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  • DOI: https://doi.org/10.1007/978-3-030-32189-5_8

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-32188-8

  • Online ISBN: 978-3-030-32189-5

  • eBook Packages: MedicineMedicine (R0)

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