Abstract
Human herpesvirus type 8 (HHV8) causes several lymphoproliferative disorders, including multicentric Castleman disease (MCD), HHV8-positive diffuse large B-cell lymphoma (DLBCL), HHV8-positive germinotropic lymphoproliferative disorder (GLPD), and primary effusion lymphoma (PEL). While representing a spectrum of the disease processes, these lymphoproliferative disorders demonstrate similar cytomorphology and immunophenotypic profile. The diagnosis can be challenging because of their low occurrence rate and ambiguous phenotypes.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Kim Y, Leventaki V, Bhaijee F, Jackson CC, Medeiros LJ, Vega F. Extracavitary/solid variant of primary effusion lymphoma. Ann Diagn Pathol. 2012;16(6):441–6.
Peker D, Alkan S, Zhang L, Martinez A. HIV-associated plasmablastic multicentric Castleman disease with microlymphoma coinfected with HHV8 and EBV. J Hematop. 2012;6(2):109–14.
Lee YM, Kim JM, Kim SY. Human herpes virus 8/Epstein-Barr virus-copositive, plasmablastic microlymphoma arising in multicentric Castleman’s disease of an immunocompetent patient. J Pathol Transl Med. 2017;51(1):99–102.
Papoudou-Bai A, Hatzimichael E, Kyriazopoulou L, Briasoulis E, Kanavaros P. Rare variants in the spectrum of human herpesvirus 8/Epstein-Barr virus-copositive lymphoproliferations. Hum Pathol. 2015;46(10):1566–71.
Seliem RM, Griffith RC, Harris NL, Beheshti J, Schiffman FJ, Longtine J, Kutok J, et al. HHV-8+, EBV+ multicentric plasmablastic microlymphoma in an HIV+ Man: the spectrum of HHV-8+ lymphoproliferative disorders expands. Am J Surg Pathol. 2007;31(9):1439–45.
Wang W, Kanagal-Shamanna R, Medeiros LJ. Lymphoproliferative disorders with concurrent HHV8 and EBV infection: beyond primary effusion lymphoma and germinotropic lymphoproliferative disorder. Histopathology. 2018;72(5):855–61.
Crane GM, Ambinder RF, Shirley CM, Fishman EK, Kasamon YL, Taube JM, et al. HHV-8-positive and EBV-positive intravascular lymphoma: an unusual presentation of extracavitary primary effusion lymphoma. Am J Surg Pathol. 2014;38(3):426–32.
Ferry JA, Sohani AR, Longtine JA, Schwartz RA, Harris NL. HHV8-positive, EBV-positive Hodgkin lymphoma-like large B-cell lymphoma and HHV8-positive intravascular large B-cell lymphoma. Mod Pathol. 2009;22(5):618–26.
Gonzalez-Farre B, Martinez D, Lopez-Guerra M, Xipell M, Monclus E, Rovira J, et al. HHV8-related lymphoid proliferations: a broad spectrum of lesions from reactive lymphoid hyperplasia to overt lymphoma. Mod Pathol. 2017;30(5):745–60.
Courville EL, Sohani AR, Hasserjian RP, Zukerberg LR, Harris NL, Ferry JA. Diverse clinicopathologic features in human herpesvirus 8-associated lymphomas lead to diagnostic problems. Am J Clin Pathol. 2014;142(6):816–29.
Pan ZG, et al. Extracavitary KSHV-associated large B-Cell lymphoma: a distinct entity or a subtype of primary effusion lymphoma? Study of 9 cases and review of an additional 43 cases. Am J Surg Pathol. 2012;36(8):1129–40.
Pan Z, Zhang QY, Lu ZB, Quinto T, Rozenvald IB, Liu LT, et al. CD3-positive plasmablastic B-cell neoplasms: a diagnostic pitfall. Mod Pathol. 2018;31:718.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Wang, W., Medeiros, L.J. (2020). HHV8-Associated Lymphoproliferative Disorders. In: Wang, E., Lagoo, A.S. (eds) Practical Lymph Node and Bone Marrow Pathology. Practical Anatomic Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-32189-5_19
Download citation
DOI: https://doi.org/10.1007/978-3-030-32189-5_19
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-32188-8
Online ISBN: 978-3-030-32189-5
eBook Packages: MedicineMedicine (R0)