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Synthesis and Characterization of Self-assembled Submicron Particles Based on Biotinylated N-palmitoyl Chitosan

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4th International Conference on Nanotechnologies and Biomedical Engineering (ICNBME 2019)

Part of the book series: IFMBE Proceedings ((IFMBE,volume 77))

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Abstract

Self-assembled particles based on amphiphilic chitosan derivatives represent a promising research area, as remarkable properties of these polymeric structures can significantly improve their biological behaviour of the drug delivery systems. In the same time, biotin has been proposed as an active targeting molecule in anti-tumoral formulations. In this paper, self-assembled submicron particles based on biotinilated N-palmitoyl chitosan and loaded with a chemotherapeutic agent (Paclitaxel) have been prepared by dialysis method combined with ultrasonication. The composition of the particles has been confirmed by FT-IR Spectroscopy. Paclitaxel loaded particles exhibited narrow size distribution, negative charge, a pH-dependent release profile of drug and redispersion ability in simulated body fluids, features which can be useful in drug delivery applications.

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Acknowledgements

This work was supported by a grant of Grigore T. Popa University of Medicine and Pharmacy, no. 27499/2018.

Conflict of Interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Faculty of Medical Bioengineering, Grigore T. Popa University of Medicine and Pharmacy, 9-13 Kogalniceanu Street, Iasi, Romania

    V. Balan, C. I. Moise & L. Verestiuc

Authors
  1. V. Balan
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  2. C. I. Moise
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  3. L. Verestiuc
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Corresponding author

Correspondence to V. Balan .

Editor information

Editors and Affiliations

  1. Academy of Sciences of Moldova, Chisinau, Moldova

    Ion Tiginyanu

  2. Department of Microelectronics and Biomedical Engineering, Technical University of Moldova, Chisinau, Moldova

    Victor Sontea

  3. Department of Microelectronics and Biomedical Engineering, Technical University of Moldova, Chisinau, Moldova

    Serghei Railean

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Balan, V., Moise, C.I., Verestiuc, L. (2020). Synthesis and Characterization of Self-assembled Submicron Particles Based on Biotinylated N-palmitoyl Chitosan. In: Tiginyanu, I., Sontea, V., Railean, S. (eds) 4th International Conference on Nanotechnologies and Biomedical Engineering. ICNBME 2019. IFMBE Proceedings, vol 77. Springer, Cham. https://doi.org/10.1007/978-3-030-31866-6_62

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  • DOI: https://doi.org/10.1007/978-3-030-31866-6_62

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-31865-9

  • Online ISBN: 978-3-030-31866-6

  • eBook Packages: EngineeringEngineering (R0)

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