Abstract
This chapter covers crucial aspects of the formulation of pharmaceutical suspensions. Properties relevant to suspension stability and drug delivery are discussed, including particle settling, flocculation, particle aggregation, viscosity, zeta potential, and Ostwald ripening are discussed. Methods of particle size reduction are introduced, including those to produce nanoparticles. An extensive discussion of relevant excipients is also included.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Further Reading
Suggested readings for the student include the following texts:
Iyer AK, et al. Exploiting the enhanced permeability and retention effect for tumor targeting. Drug Discov Today. 2006;11(17):812–8.
Jermain SV, Brough C, Williams RO III. Amorphous solid dispersions and nanocrystal technologies for poorly water-soluble drug delivery–an update. Int J Pharm. 2018;535(1–2):379–92.
Leleux J, Williams RO III. Recent advances in mechanical reduction methods: particulate systems. Drug Dev Ind Pharm. 2014;40(3):289–300.
Wong J, et al. Suspensions for intravenous (IV) injection: a review of development, preclinical and clinical aspects. Adv Drug Deliv Rev. 2008;60:939–54.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2019 American Association of Pharmaceutical Scientists
About this chapter
Cite this chapter
Brunaugh, A.D., Smyth, H.D.C., Williams III, R.O. (2019). Disperse Systems: Suspensions. In: Essential Pharmaceutics. AAPS Introductions in the Pharmaceutical Sciences. Springer, Cham. https://doi.org/10.1007/978-3-030-31745-4_6
Download citation
DOI: https://doi.org/10.1007/978-3-030-31745-4_6
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-31744-7
Online ISBN: 978-3-030-31745-4
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)