Abstract
This chapter presents an extensive overview of the concepts of delayed-release, sustained-release, and pulsatile-release for drug delivery. Formulation approaches and delivery technologies are discussed in detail, along with the required performance testing for modified-release dosage forms. Abuse-deterrent technologies are also introduced.
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Further Reading
Suggested readings for the student include the following texts:
Food and Drug Administration Center for Drugs Evaluation Research. Abuse-deterrent opioids-evaluation and labeling. Maryland: FDA; 2015.
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Miller DA, Gamba M, Sauer D, Purvis TP, Clemens NT, Williams RO III. Evaluation of the USP dissolution test method a for enteric-coated articles by planar laser-induced fluorescence. Int J Pharm. 2007;330:61072.
Perucca E. Extended-release formulations of antiepileptic drugs: rationale and comparative value. Epilep Curr. 2009;9(6):153–7.
Rhodes CT, Porter SC. Coatings for controlled-release drug delivery systems. Drug Dev Ind Pharm. 1998;24(12):1139–54.
Roy P, Shahiwala A. Multiparticulate formulation approach to pulsatile drug delivery: current perspectives. J Control Release. 2009;134(2):74–80.
Verma RK, Krishna DM, Garg S. Formulation aspects in the development of osmotically controlled oral drug delivery systems. J Control Release. 2002;79(1–3):7–27.
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© 2019 American Association of Pharmaceutical Scientists
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Brunaugh, A.D., Smyth, H.D.C., Williams III, R.O. (2019). Modified Release Solid Oral Dosage Forms. In: Essential Pharmaceutics. AAPS Introductions in the Pharmaceutical Sciences. Springer, Cham. https://doi.org/10.1007/978-3-030-31745-4_4
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DOI: https://doi.org/10.1007/978-3-030-31745-4_4
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Publisher Name: Springer, Cham
Print ISBN: 978-3-030-31744-7
Online ISBN: 978-3-030-31745-4
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