Abstract
Extrusion bioprinting is one of the most studied additive manufacturing technologies thanks to the huge possibilities in the creation of engineered tissues that it provides. Despite all research performed about bioprinting there is not enough information on how inlet velocities affect the pressure distribution. In this way, we have carried out CFD simulations to check how different inlet velocities can affect the pressure distribution in the tip of a nozzle.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Kang, H.-W., Yoo, J.J., Atala, A.: Bioprinted scaffolds for cartilage tissue engineering. Cartil. Tissue Eng. Methods Protoc. 1340, 981–995 (2015)
Hesuani, Y.D., et al.: Design and Implementation of Novel Multifunctional 3D Bioprinter. 3d Print. Addit. Manuf. 3(1), 65–68 (2016)
Cubo, N., Garcia, M., del Cañizo, J.F., Velasco, D., Jorcano, J.L.: 3D bioprinting of functional human skin: production and in vivo analysis. Biofabrication 9(1), 15006 (2016)
Ahmed, E.M.: Hydrogel: preparation, characterization, and applications: a review. J. Adv. Res. 6(2), 105–121 (2015)
He, Y., Yang, F., Zhao, H., Gao, Q., Xia, B., Fu, J.: Research on the printability of hydrogels in 3D bioprinting. Sci. Rep. 6, 29977 (2016)
Panwar, A., Tan, L.P.: Current status of bioinks for micro-extrusion-based 3D bioprinting. Molecules 21(6), E685 (2016)
Alberts, B., et al.: Mollecular biology of the cell. In: Anderson, M., Granum, S. (eds.) Garland Science, Taylor & Francis Group, LLC (2008)
Zhao, Y., Li, Y., Mao, S., Sun, W., Yao, R.: The influence of printing parameters on cell survival rate and printability in microextrusion-based 3D cell printing technology. Biofabrication 7(4), 1–11 (2015)
Pati, F., Jang, J., Lee, J.W., Cho, D.W.: Extrusion bioprinting (2015)
Ozbolat, I.T., Moncal, K.K., Gudapati, H.: Evaluation of bioprinter technologies. Addit. Manuf. 13, 179–200 (2017)
Ning, L., Chen, X.: A brief review of extrusion-based tissue scaffold bio-printing. Biotechnol. J. 12(8), 1–16 (2017)
Yuan, W., Schnerr, G.H.: Numerical simulation of two-phase flow in injection nozzles: interaction of cavitation and external jet formation. J. Fluids Eng. 125(6), 963–969 (2004)
Zekovic, S., Dwivedi, R., Kovacevic, R.: Numerical simulation and experimental investigation of gas-powder flow from radially symmetrical nozzles in laser-based direct metal deposition. Int. J. Mach. Tools Manuf. 47(1), 112–123 (2007)
Reid, J.A., Mollica, P.A., Johnson, G.D., Ogle, R.C., Bruno, R.D., Sachs, P.C.: Accessible bioprinting: adaptation of a low-cost 3D-printer for precise cell placement and stem cell differentiation. Biofabrication 8(2), 25017 (2016)
Martanto, W., Baisch, S.M., Costner, E.A., Prausnitz, M.R., Smith, M.K.: Fluid dynamics in conically tapered microneedles. AIChE J. 51(6), 1599–1607 (2005)
COMSOL Multiphysics: Theory for the Two-Phase Flow Interfaces - CFD Module User’s Guide. Manual, p. 620 (2014)
Acknowledgment
This work was supported by Consejeráa de Economía e Infraestructuras, Junta de Extremadura. Project number IB16200 “Optimización y mejora de técnicas de bioimpresión para regeneración de cartílago y prótesis vasculares" and predoctoral grant number PD16067.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Ethics declarations
The authors declare that they have no conflict of interest.
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this paper
Cite this paper
Gómez-Blanco, J.C., Mancha-Sánchez, E., Ortega-Morán, J.F., Díaz-Parralejo, A., Sánchez-Margallo, F.M., Pagador-Carrasco, J.B. (2020). Computational Fluid Dynamics Study of Inlet Velocity on Extrusion-Based Bioprinting. In: Henriques, J., Neves, N., de Carvalho, P. (eds) XV Mediterranean Conference on Medical and Biological Engineering and Computing – MEDICON 2019. MEDICON 2019. IFMBE Proceedings, vol 76. Springer, Cham. https://doi.org/10.1007/978-3-030-31635-8_64
Download citation
DOI: https://doi.org/10.1007/978-3-030-31635-8_64
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-31634-1
Online ISBN: 978-3-030-31635-8
eBook Packages: EngineeringEngineering (R0)