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Chaetomium’s Alkaloids

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Recent Developments on Genus Chaetomium

Part of the book series: Fungal Biology ((FUNGBIO))

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Abstract

Fungi of the genus Chaetomium are a rich source of novel and bioactive secondary metabolites of great reputation. The genus contains 200 species growing on dung, straw, wet paper, cloth, and cotton fiber. This chapter covers the known alkaloids so far identified and isolated from Chaetomium fungi. Up till now, a variety of more secondary metabolites belonging to diverse structural types, such as chaetoglobosins, epipolythiodioxopiperazines, azaphilones, xanthones, anthraquinones, chromones, depsidones, terpenoids, and steroids, have been discovered. Most of these fungal metabolites exhibit antitumor, cytotoxic, antimalarial, enzyme inhibitory, antibiotic, and other activities. This compilation shows chaetoglobosins are the most diverse class among all other alkaloids identified to date.

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References

  • Abdel-Lateff A (2008) Chaetominedione, a new tyrosine kinase inhibitor isolated from the algicolous marine fungus Chaetomium sp. Tetrahedron Lett 49:6398–6400

    Article  CAS  Google Scholar 

  • Ames LM (1949) New cellulose destroying fungi isolated from military material and equipment. Mycologia 41(6):637–648. https://doi.org/10.2307/3755020. JSTOR 3755020

    Article  Google Scholar 

  • Ames LM (1961) A monograph of the Chaetomiaceae. Verlag von J Cramer, Lehre, p 2, 3, 9, 21

    Google Scholar 

  • Ames LM (1963) A monograph of the Chaetomiaceae. U.S. Army Research and Development, Series 2

    Google Scholar 

  • Binder M, Tamm C (1973) The cytochalasans: a new class of biologically active microbial metabolites. Angew Chem Int Ed Engl 12:370–380

    Article  CAS  PubMed  Google Scholar 

  • Breinholt J, Demuth H, Heide M, Jensen GW, Moller IL, Nielsen RI, Olsen CE, Rosendahl CN (1996) Prenisatin (5-(3-methyl2-butenyl)-indole-2,3-dione): antifungal isatin derivative from Chaetomium globosum. Acta Chem Scand 50:443–445

    Article  CAS  Google Scholar 

  • Brewer D, Jerram WA, Taylor A (1968) The production of cochliodinol and a related metabolite by Chaetomium species. Can J Microbiol 14:861–866

    Article  CAS  PubMed  Google Scholar 

  • Brewer D, Jerram WA, Taylor A (1970) The toxicity of cochliodinol, an antibiotic metabolite of Chaetomium spp. Can J Microbiol 16:433–440

    Article  CAS  PubMed  Google Scholar 

  • Brewer D, Mcinnes AG, Smith DG, Taylor A, Walter JA, Loosli HR, Kis ZL (1976) Sporidesmins. Part 16. The structure of chetomin, a toxic metabolite of Chaetomium cochliodes, by nitrogen-15 and carbon-13 nuclear magnetic resonance spectroscopy. J Chem Soc Perkin Trans 1:1248–1251

    Google Scholar 

  • Brewer D, Jen WC, Jones GA, Taylor A (1984) The antibacterial activity of some naturally occurring 2,5-dihydroxy-l,4-benzoquinones. Canadian Journal of Microbiology 30(8):1068–1072

    Article  CAS  PubMed  Google Scholar 

  • Chen C, Wang J, Liu J, Zhu H, Sun B, Wang J, Zhang J, Luo Z, Yao G, Xue Y, Zhang Y (2015a) Armochaetoglobins A–J: Cytochalasan alkaloids from Chaetomium globosum TW1-1, a fungus derived from the terrestrial arthropod Armadillidium vulgar. J Nat Prod 78(6):1193–1201. https://doi.org/10.1021/np5006

    Article  CAS  PubMed  Google Scholar 

  • Chen C, Zhu H, Li X-N, Yang J, Wang J, Li G, Li Y, Tong Q, Yao G, Luo Z, Xue Y, Zhang Y (2015b) Armochaeglobines A and B, two new indole-based alkaloids from the arthropod-derived fungus Chaetomium globosum. Org Lett 17(3):644–647. https://doi.org/10.1021/ol503666b

    Article  CAS  PubMed  Google Scholar 

  • Chen C, Tong Q, Zhu H, Tan D, Zhang J, Xue Y, Yao G, Luo Z, Wang J, Wang Y, Zhang Y (2016) Nine new cytochalasan alkaloids from Chaetomium globosum TW1-1 (Ascomycota, Sordariales). Sci Rep 6:18711

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chivers AH (1915) Details – a monograph of the genera Chaetomium and Ascotricha. Biodiversity Heritage Library. https://doi.org/10.5962/bhl.title.97551

  • Cherrier T, Suzanne S, Redel L, Calao M, Marban C, Samah B, Mukerjee R, Schwartz C, Gras G, Sawaya BE, Zeichner SL, Aunis D, Van Lint C, Rohr O (2009) p21WAF1 gene promoter is epigenetically silenced by CTIP2 and SUV39H1. Oncogene 28(38):3380–3389

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cui CM, Li XM, Li CS, Proksch P, Wang BG (2010) Cytoglobosins A-G, cytochalasans from a marine-derived endophytic fungus, Chaetomium globosum QEN-14. J Nat Prod 73:729–733

    Article  CAS  PubMed  Google Scholar 

  • Cook KM, Hilton ST, Meeinovie J, Motherwell WB, Figg WD, Schofield CJ (1996) Epidithiodiketopiperazines block the interaction between hypoxia inducible factor-α (HIF- α) and p300 by a zinc ejection mechanism. J Biol Chem 284:2681–26838

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Debbab A, Aly AH, Edrada-Ebel RA, Müller WEG, Mosaddak M, Hakiki A, Ebel R, Proksch P (2009) Bioactive secondary metabolites from the endophytic fungus Chaetomium sp. isolated from Salvia officinalis growing in Morocco. Biotechnol Agron Soc Environ 13:229–234

    CAS  Google Scholar 

  • Ding G, Song YC, Chen JR, Xu C, Ge HM, Wang XT, Tan RX (2006) Chaetoglobosin U, a cytochalasan alkaloid from endophytic Chaetomium globosum IFB-E019. J Nat Prod 69:302–304

    Article  CAS  PubMed  Google Scholar 

  • Dong JY, He HP, Shen YM, Zhang KQ (2005) Nematicidal epipolysulfanyldioxopiperazines from Gliocladium roseum. J Nat Prod 68:1510–1513

    Article  CAS  PubMed  Google Scholar 

  • Fredenhagen A, Petersen F, Tintelnot-Blomley M, Rösel J, Mett H, Hug P (1997) Semicochliodinol A and B: inhibitors of HIV-1 protease and EGF-R protein tyrosine kinase related to asterriquinones produced by the fungus Chrysosporium merdarium. J Antibiot 50:395–401

    Article  CAS  Google Scholar 

  • Gardiner DM, Waring P, Howlett B (2005) The epipolythiodioxopiperazine (ETP) class of fungal toxins: distribution, mode of action, functions and biosynthesis. J Microbiol 151:1021–1032

    Article  CAS  Google Scholar 

  • Ge HM, Zhang WY, Ding G, Saparpakorn P, Song YC, Hannongbua S, Tan RX (2008) Chaetoglobins A and B, two unusual alkaloids from endophytic Chaetomium globosum culture. Chem Commun (45):5978–5980

    Google Scholar 

  • Ge HM, Zhang Q, Xu SH, Guo ZK, Song YC, Huang WY, Tan RX (2011) Chaetoglocins A-D, four new metabolites from the endophytic fungus Chaetomium globosum. Planta Med 77:277–280

    Article  CAS  PubMed  Google Scholar 

  • Geiger WB (1949) Chetomin, an antibiotic substance from Chaetomium cochliodes III. Composition and functional groups. Arch Biochem 21:125–131

    CAS  PubMed  Google Scholar 

  • Geiger WB, Conn JE, Waksman SA (1944) Chetomin, a new antibiotic substance produced by Chaetomium cochliodes I. Formation and properties. II. Isolation and concentration. J Bacteriol 48:531–536

    CAS  PubMed  PubMed Central  Google Scholar 

  • Ichihara, A., Katayama, K., Teshima, H., Oikawa, H., and Sakamura, S. (1996) Chaetoglobosin O and other phytotoxic metabolites from Cylindrocladium floridanum, a causal fungus of alfalfa black rot disease. Biosci. Biotech. Biochem., 60, 360–361

    Article  CAS  PubMed  Google Scholar 

  • Iwasa E, Hamashima Y, Fujishiro S, Higuchi E, Ito A, Yoshida M, Sodeoka M (2010) Total synthesis of (+)-chaetocin and its analogues: their histone methyltransferase G9a inhibitory activity. J Am Chem Soc 132:4078–4079

    Article  CAS  PubMed  Google Scholar 

  • Jiao W, Feng Y, Blunt JW, Cole AL, Munro MH (2004) Chaetoglobosins Q, R, and T, three further new metabolites from Chaetomium globosum. J Nat Prod 67:1722–1725

    Article  CAS  PubMed  Google Scholar 

  • Jiao RH, Xu S, Liu JY, Ge HM, Ding H, Xu C, Zhu HL, Tan RX (2006) Chaetominine, a cytotoxic alkaloid produced by endophytic Chaetomium sp. IFB-E015. Org Lett 8:57095712

    Article  CAS  Google Scholar 

  • Kang JG, Kim KK, Kang KY (1999) Antagonism and structural identification of antifungal compound from Chaetomium cochliodes against phytopathogenic fungi. Agric Chem Biotechnol 42:146–150

    CAS  Google Scholar 

  • Kanokmedhakul S, Kanokmedhakul K, Phonkerd N, Soytong K, Kongsaeree P, Suksamrarn A (2002) Antimycobacterial anthraquinone-chromanone compound and diketopiperazine alkaloid from the fungus Chaetomium globosum KMITL-N0802. Planta Med 68:834–836

    Article  CAS  PubMed  Google Scholar 

  • Kikuchi T, Kadota S, Nakamura K, Nishi A, Taga T, Kaji T, Osaki K, Tubaki K (1982) Dethio-tetra(methylthio) chetomin, a new antimicrobial metabolite of chaetomium globosum Kinze ex Fr. Structure and partial synthesis from chetomin. Chem Pharm Bull 30:3846–3848

    Article  CAS  Google Scholar 

  • Kirk PM, Cannon PF, Minter DW, Stalpers JA (2008) Dictionary of the Fungi, 10th edn. CABI, Wallingford, p 131. ISBN 978-0-85199-826-8

    Google Scholar 

  • Ko HR, Kim BY, Ahn SC, Oh WK, Kim JH, Lee HS, Kim HM, Han SB, Mheen TI, Ahn JS (1998) Chaetoglobosin A, an inhibitor of bleb formation on K562 cells induced by phorbol 12,13-dibutyrate. J Microbiol Biotechnol 8:705–709

    CAS  Google Scholar 

  • Kobayashi H, Namikoshi M, Yoshimoto T, Yokochi T (1996) A screening method for antimitotic and antifungal substances using conidia of Pyricularia oryzae, modification and application to tropical marine fungi. J Antibiot 49:873–879

    Article  CAS  Google Scholar 

  • Li GY, Li BG, Yang T, Yan JF, Liu GY, Zhang GL (2006) Chaetoindicines A—C, Three Isoquinoline Alkaloids from the Fungus Chaetomi-um indicum. Org. Lett.8 16:3613-3615.

    Google Scholar 

  • Li X, Tia Y, Yang S-X, Zhang Y-M, Qin J-C (2013) Cytotoxic azaphilone alkaloids from Chaetomium globosum TY1. Bioorg Med Chem Lett 23(10):2945–2947

    Article  CAS  PubMed  Google Scholar 

  • Mahmood ZA, Ahmed SW, Azhar I, Sualeh M, Baig MT, Zoha S (2010) Bioactive alkaloids produced by fungi I. Updates on alkaloids from the species of the genera boletus, fusarium and psilocybe. Pak J Pharm Sci 23(3):349–357

    CAS  PubMed  Google Scholar 

  • McInnes AG, Taylor A, Walter JA (1976) The structure of chetomin. J Am Chem Soc 98:6741–6741

    Article  CAS  PubMed  Google Scholar 

  • Meiler D, Taylor A (1971) The effect of cochliodinol, a metabolite of Chaetomium cochliodes, on the respiration of microsopores of Fusarium oxysporum. Can J Microbiol 17:83–86

    Article  CAS  PubMed  Google Scholar 

  • Momesso LDS, Kawano CY, Ribeiro PH, Nomizo A, Goldman G, Pupo MT (2008) Chaetoglobosins produced by Chaetomium globosum, endophytic fungus found in association with Viguiera robusta Gardn (Asteraceae). Quim Nova 31:1680–1685

    Article  CAS  Google Scholar 

  • Müllbacher A, Waring P, Tiwari-Palni U, Eichner RD (1986) Structural relationship of epipolythiodioxopiperazines and their immunomodulating activity. Mol Immunol 23:231–235

    Article  PubMed  Google Scholar 

  • Namgoong J, Yeon S-W, Paek N-S, Kim T-H, Kim Y-H, Kim C-J, Kim K-W (1998) Isolation and structural determination of anti-Helicobacter pylori compound, fungus 60686. Sanop Misaengmul Hakhoechi 26:137–142

    CAS  Google Scholar 

  • Oikawa H, Murakami Y, Ichihara A (1991) New plausible precursors of chaetoglobosin a accumulated by treatment of chaetomium subaffine with cytochrome P-450 inhibitors. Tetrahedron Lett 32:4533–4536

    Article  CAS  Google Scholar 

  • Oikawa H, Murakami Y, Ichihara A (1992a) Biosynthetic study of chaetoglobosin A: origins of the oxygen and hydrogen atoms, and indirect evidence for biological Diels–Alder reaction. J Chem Soc Perkin Trans 1:2955–2959

    Article  Google Scholar 

  • Oikawa H, Murakami Y, Ichihara A (1992b) Useful approach to find the plausible biosynthetic precursors of secondary metabolites using P-450 inhibitors: postulated intermediates of chaetoglobosin A. J Chem Soc Perkin Trans 1:2949–2954

    Article  Google Scholar 

  • Oikawa H, Murakami Y, Ichihara A (1993) 20-ketoreductase activity of chaetoglobosin A and prochaetoglobosins in a cell-free system of Chaetomium subaffine and the isolation of new chaetoglobosins. Biosci Biotechnol Biochem 57:628–631

    Article  CAS  Google Scholar 

  • Probst A, Tamm C (1981a) 19-O-acetylchaetoglobosin B and 19-Oacetylchaetoglobosin D, two new metabolites of Chaetomium globosum. Helv Chim Acta 64:2056–2064

    Article  CAS  Google Scholar 

  • Probst A, Tamm C (1981b) Biosynthesis of the cytochalasans. Biosynthetic studies on chaetoglobosin A and 19-Oacetylchaetoglobosin A. Helv Chim Acta 64:2065–2077

    Article  CAS  Google Scholar 

  • Qin JC, Bai L, Li XM, Zhang YM, Gao JM, Laatsch H (2009a) Isolation and identification of the metabolites produced by an endophytic fungus Chaetomium globosum ZY-22 from Ginkgo biloba. Acta Botan Boreali-Occiden Sin 29:1264–1268

    CAS  Google Scholar 

  • Qin JC, Zhang YM, Gao JM, Bai MS, Yang SX, Laatsch H, Zhang AL (2009b) Bioactive metabolites produced by Chaetomium globosum, an endophytic fungus isolated from Ginkgo biloba. Bioorg Med Chem Lett 19:1572–1574

    Article  CAS  PubMed  Google Scholar 

  • Safe S, Taylor A (1972) Sporidesmins. Part XIII. Ovine 111-thrift in Nova Scotia. Part 11. The characterisation of chetomin, a toxic metabolite of Chaetomium cochliodes and Chaetomium globosum. J Chem Soc Perkin Trans 1:472–479

    Article  Google Scholar 

  • Saito T, Koyama K, Natori S, Iitaka Y (1985) Chetracin A, a new epipolythiodioxopiperazine having a tetrasulfide bridge from Chaetomium abuens and C. retardatum. Tetrahedron Lett 26:4731–4734

    Article  CAS  Google Scholar 

  • Saito T, Suzuki Y, Koyama K, Natori S, Iitaka Y, Kinoshita T (1988) Chetracin A and chaetocins B and C, three new epipolythiodioxopiperazines from Chaetomium spp. Chem Pharm Bull 36:1942–1956

    Article  CAS  Google Scholar 

  • Scherlach K, Boettger D, Remme N, Hertweck C (2010) The chemistry and biology of cytochalasans. Nat Prod Rep 27:869–886

    Article  CAS  PubMed  Google Scholar 

  • Sekita S, Yoshihira K, Natori S, Kuwano H (1973) Structures of chaetoglobosin A and B, cytotoxic metabolites of Chaetomium globosum. Tetrahedron Lett 14:2109–2112

    Article  Google Scholar 

  • Sekita S, Yoshihira K, Natori S, Kuwano H (1976) Structures of chaetoglobosins C, D, E, and F, cytotoxic indol-3-yl[13]cytochalasans from Chaetomium globosum. Tetrahedron Lett 17:1351–1354

    Article  Google Scholar 

  • Sekita S, Yoshihira K, Natori S, Kuwano H (1977) Chaetoglobosins G and J, cytotoxic indol-3-yl[13]-cytochalasans from Chaetomium globosum. Tetrahedron Lett 18:2771–2774

    Article  Google Scholar 

  • Sekita S, Yoshihira K, Natori S, Udagawa S, Muroi T, Sugiyama Y, Kurata H, Umeda M (1981) Mycotoxin production by Chaetomium spp. and related fungi. Can J Microbiol 27:766–772

    Article  CAS  PubMed  Google Scholar 

  • Sekita S, Yoshihira K, Natori S, Kuwano H (1982a) Chaetoglobosins, cytotoxic 10-(indo-3-yl)-[13] cytochalasans from Chaetomium spp. II. Structures of chaetoglobosins A, B, and D. Chem Pharm Bull 30:1618–1628

    Article  CAS  Google Scholar 

  • Sekita S, Yoshihira K, Natori S, Kuwano H (1982b) Chaetoglobosins, cytotoxic 10-(indol-3-yl)-[13] cytochalasans from Chaetomium spp. III. Structures of chaetoglobosins C, E, F, G, and J. Chem Pharm Bull 30:1629–1638

    Article  CAS  Google Scholar 

  • Sekita S, Yoshihira K, Natori S, Udagawa S, Sakabe F, Kurata H, Umeda M (1982c) Chaetoglobosins, cytotoxic 10-(indol-3-yl)[13] cytochalasans from Chaetomium spp. I. Production, isolation and some cytological effects of chaetoglobosins A-J. Chem Pharm Bull 30:1609–1617

    Article  CAS  Google Scholar 

  • Sekita S, Yoshihira K, Natori S (1983) Chaetoglobosins, cytotoxic 10(indol-3-yl)-[13]cytochalasans from Chaetomium spp. IV. Carbon13 nuclear magnetic resonance spectra and their application to a biosynthetic study. Chem Pharm Bull 31:490–498

    Google Scholar 

  • Shinohara C, Chikanishi T, Nakashima S, Hashimoto A, Hamanaka A, Endo A, Hasumi K (2000) Enhancement of fibrinolytic activity of vascular endothelial cells by chaetoglobosin A, crinipellin B, geodin and triticone B. J Antibiot 53:262268

    Article  Google Scholar 

  • Silverton JV, Akiyama T, Kabuto C, Sekita S, Yoshihira K, Natori S (1976) X-ray analysis of chaetoglobosin A, an indol-3-yl[13]cytochalasan from Chaetomium globosum. Tetrahedron Lett 17:1349–1350

    Article  Google Scholar 

  • Staab A, Loeffler J, Said HM, Diehlmann D, Katzer A, Beyer M, Fleischer M, Schwab F, Baier K, Einsele H, Flentje M, Vordermark D (2007) Effects of HIF-1 inhibition by chetomin on hypoxia-related transcription and radiosensitivity in HT 1080 human fibrosarcoma cells. BMC Cancer 7:213219

    Article  CAS  Google Scholar 

  • Teng Y, Iuchi K, Iwasa E, Fujishiro S, Hamashima Y, Dodo K, Sodeoka M (2010) Unnatural enantiomer of chaetocin shows strong apoptosis-inducing activity through caspase8/caspase-3 activation. Bioorg Med Chem Lett 20:50855088

    Article  CAS  Google Scholar 

  • Thohinung S, Kanokmedhakul S, Kanokmedhakul K, Kukongviriyapan V, Tusskorn O, Soytong K (2010) Cytotoxic 10(indol-3-yl)-[13]cytochalasans from the fungus Chaetomium elatum ChE01. Arch Pharm Res 33:1135–1141

    Article  CAS  PubMed  Google Scholar 

  • Tibodeau JD, Benson LM, Isham CR, Owen WG, Bible KC (2009) The anticancer agent chaetocin is a competitive substrate and inhibitor of thioredoxin reductase. Antioxid Redox Signal 11:1097–1106

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Udagawa S, Muroi T, Kurata H, Sekita S, Yoshihira K, Natori S, Umeda M (1979) The production of chaetoglobosins, sterigmatocystin, O-methylsterigmatocystin, and chaetocin by Chaetomium spp. and related fungi. Can J Microbiol 25:170–177

    Article  CAS  PubMed  Google Scholar 

  • Umeda M, Ohtsubo K, Saito M, Sekita S, Yoshihira K, Natori S, Udagawa S, Sakabe F, Kurata H (1975) Cytotoxicity of new cytochalasans from Chaetomium globosum. Experientia 31:435–438

    Article  CAS  PubMed  Google Scholar 

  • von Arx JA, Guarro J, Figueras MJ (1986) The ascomycete genus Chaetomium. Beih Nova Hedwig 84:1–162

    Google Scholar 

  • Von Wallbrunn C, Luftmann H, Bergander K, Meinhardt F (2001) Phytotoxic chaetoglobosins are produced by the plant pathogen Calonectria morganii (anamorph Cylindrocladium scoparium). J Gen Appl Microbiol 47:33–38

    Article  Google Scholar 

  • Walksman SA, Bugie E (1944) Chaetomin, a new antibiotic substance produced by Chaetomium cochliodes: I. Formation and properties. J Bacteriol 48:527–530

    Google Scholar 

  • Wang S, Li XM, Teuscher F, Li DL, Diesel A, Ebel R, Proksch P, Wang BG (2006) Chaetopyranin, a benzaldehyde derivative, and other related metabolites from Chaetomium globosum, an endophytic fungus derived from the marine red alga Polysiphonia urceolata. J Nat Prod 69:1622–1625

    Article  CAS  PubMed  Google Scholar 

  • Waring P, Eichner RD, Müllbacher A (1988) The chemistry and biology of the immunomodulating agent gliotoxin and related epipolythiodioxopiperazines. Med Res Rev 8:499–524

    Article  CAS  PubMed  Google Scholar 

  • Weindling R (1941) Experimental consideration of the mold toxins of Gliocladium and Trichoderma. Phytopathology 31:991–1003

    CAS  Google Scholar 

  • Weindling R, Emerson OH (1936) The isolation of a toxic substance from the culture filtrate of Trichoderma. Phytopathology 26:1068–1070

    CAS  Google Scholar 

  • Wu ZJ, Li GY, Fang DM, Qi HY, Ren WJ, Zhang GL (2007) Electrospray tandem mass spectrometry of epipolythiodioxopiperazines. J Mass Spectrom 42:749–760

    Article  CAS  PubMed  Google Scholar 

  • Xu G-B, He G, Bai H-H, Yang T, Zhang G-L, Wu L-W, Li G-Y (2015) Indole alkaloids from Chaetomium globosu. J Nat Prod 78(7):1479–1148. https://doi.org/10.1021/np5007235

    Article  CAS  PubMed  Google Scholar 

  • Zhang J, Ge HM, Jiao RH, Li J, Peng H, Wang YR, Wu JH, Song YC, Tan RX (2010) Cytotoxic chaetoglobosins from the endophyte Chaetomium globosum. Planta Med 76:1910–1914

    Article  CAS  PubMed  Google Scholar 

  • Zhang Q, Li H-Q, Zong S-C, Gao J-M, Zhang A-L (2012) Chemical and bioactive diversities of the genus Chaetomium secondary metabolites. Mini Rev Med Chem 12(2):127–148. https://doi.org/10.2174/138955712798995066

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Institute of Chinese Medical Sciences, Avenida da Universidade, Taipa, Macau, China

    Parsa Mahmood Dar

  2. Botany Department, Faculty of Science, University of Suez Canal, Ismailia, Egypt

    Ahmed M. Abdel-Azeem

  3. Microbial Biotechnology Department, National Research Centre, Giza, Egypt

    Shimaa Ragab Hamed

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  1. Parsa Mahmood Dar
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  2. Ahmed M. Abdel-Azeem
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  1. Botany Department, Faculty of Science, Suez Canal University, Ismalilia, Egypt

    Ahmed M. Abdel-Azeem

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Dar, P.M., Abdel-Azeem, A.M., Hamed, S.R. (2020). Chaetomium’s Alkaloids. In: Abdel-Azeem, A. (eds) Recent Developments on Genus Chaetomium . Fungal Biology. Springer, Cham. https://doi.org/10.1007/978-3-030-31612-9_7

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