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Stem Cells pp 49–77Cite as

Hematopoietic Stem and Progenitor Cells (HSPCs)

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1201))

Abstract

Hematopoietic stem/progenitor cells (HSPCs) isolated from bone marrow have been successfully employed for 50 years in hematological transplantations. Currently, these cells are more frequently isolated from mobilized peripheral blood or umbilical cord blood. In this chapter, we overview several topics related to these cells including their phenotype, methods for isolation, and in vitro and in vivo assays to evaluate their proliferative potential. The successful clinical application of HSPCs is widely understood to have helped establish the rationale for the development of stem cell therapies and regenerative medicine.

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Authors and Affiliations

  1. Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA

    Kamila Bujko, Magda Kucia, Janina Ratajczak & Mariusz Z. Ratajczak

  2. Department of Regenerative Medicine, Center for Preclinical Research and Technology, Warsaw Medical University, Warsaw, Poland

    Mariusz Z. Ratajczak

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    Mariusz Z. Ratajczak

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Bujko, K., Kucia, M., Ratajczak, J., Ratajczak, M.Z. (2019). Hematopoietic Stem and Progenitor Cells (HSPCs). In: Ratajczak, M. (eds) Stem Cells. Advances in Experimental Medicine and Biology, vol 1201. Springer, Cham. https://doi.org/10.1007/978-3-030-31206-0_3

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