Abstract
Human physiology depends on countless biochemical reactions, numerous of which are codependent and interrelated. The speed and level of completion of reactions usually depend on the availability of enzymes. The enzymatic activity depends on the bioavailability of micronutrient cofactors such as vitamins and minerals. To achieve this state, metabolic reactions must reach an optimal metabolic equilibrium.
The term “metabolic correction” is used to describe a biochemical–physiological process that improves cellular biochemistry as a means to achieve metabolic or physiological optimization. Metabolic correction, through the increase of cofactors, can supply unmet enzyme needs and compensate for nutritional deficiencies/insufficiencies induced by improper nutritional intake or by the increased demand for nutrients caused by genetics, disease, medications, or physical or environmental stressors. Nutrient insufficiencies are causing an increase in morbidity and mortality, at great cost to our society. Metabolic correction improves enzymatic function and satisfies the increasing demand for nutrients. Metabolic correction can have a significant impact on the reduction of morbidity and mortality and their costs to our society, as well as contribute to improving health and well-being.
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References
González MJ, Miranda-Massari JR. Metabolic correction: a functional explanation of orthomolecular medicine. J Orthomolec Med. 2012;27(1):13–20.
Gonzalez MJ, Miranda-Massari JR, Duconge J, Allende-Vigo MZ, Jiménez-Ramírez FJ, Cintrón K, Rodríguez-Gómez JR, Rosario G, Ricart C, Santiago-Cornier JA, Zaragoza-Urdaz R, Vázquez A, Hickey S, Jabbar-Berdiel M, Riordan N, Ichim T, Santiago O, Alvarado G, Vora P. Metabolic correction: a functional biochemical mechanism against disease–part 1: concept and historical background. P R Health Sci J. 2015;34(1):3–8.
Miranda-Massari JR, Gonzalez MJ, Duconge J, Allende-Vigo MZ, Jiménez-Ramírez FJ, Hickey S, Vázquez A, Berdiel MJ, Cintrón K, Rodríguez-Gómez JR. Metabolic correction: a functional biochemical mechanism against disease–part 2: mechanisms and benefits. P R Health Sci J. 2015;34(1):9–13.
Davis DR, Epp MD, Riordan HD. Changes in USDA food composition data for 43 garden crops, 1950 to 1999. J Am Coll Nutr. 2004;23:669–82.
Ames BN, Elson-Schwab I, Silver EA. High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme-binding affinity (increased Km): relevance to genetic disease and polymorphisms. Am J Clin Nutr. 2002;75:616–58.
Ames BN. Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage. Proc Natl Acad Sci U S A. 2006;103:17589–94.
Ames BN. The metabolic tune-up: metabolic harmony and disease prevention. J Nutr. 2003;133(5 Suppl 1):1544S–8S.
Ames BN. A role for supplements in optimizing health: the metabolic tune-up. Arch Biochem Biophys. 2004;423:227–34.
Ames BN, Suh JH, Liu J. Enzymes lose binding affinity for coenzymes and substrates with age: a strategy for remediation. In: Rodriguez JKR, Kaput J, editors. Nutrigenomics: discovering the path to personalized nutrition. Hoboken: Wiley; 2006. p. 277–93.
Worthington V. Nutritional quality of organic versus conventional fruits, vegetables, and grains. J Altern Compliment Med. 2001;7:161–73.
Leape LL. Institute of medicine medical error figures are not exaggerated. JAMA. 2000;284:95–7.
The Organic Center. State of science review: nutritional superiority of organic foods. 2008. Retrieved: https://www.organic-center.org/reportfiles/NutrientContentReport.pdf. Accessed 29 Jul 2017.
Lazarou J, Pomeranz BH, Corey PN. Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies. JAMA. 1998;279:1200–5.
Miranda-Massari JR, Gonzalez MJ, Jimenez FJ, et al. Metabolic correction in the management of diabetic peripheral neuropathy: improving clinical results beyond symptom control. Curr Clin Pharmacol. 2011;6:260–73.
Richardson RA, Davidson HIM. Nutritional demands in acute and chronic illness. Proc Nutr Soc. 2003;62:777–81.
Williams RJ, Kalita DK, editors. A physician’s handbook on orthomolecular medicine. Oxford: Pergamon Press; 1978.
Prins A. Nutritional management of the burn patient. S Afr J Clin Nutr. 2009;22:9–15.
Rahm DH, Labovitz JM. Perioperative nutrition and the use of nutritional supplements. Clin Podiatr Med Surg. 2007;24:245–59.
Kakar S, Einhorn T. Importance of nutrition in fracture healing. In: Holick M, Dawson-Hughes B, editors. Nutrition and bone health. Totowa: Humana Press, Inc; 2004. p. 85–103.
Bendich A. Antioxidant vitamins and human immune responses. Vit Horm. 1996;52:35–62.
Pauling L. Orthomolecular psychiatry. Varying the concentrations of substances normally present in the human body may control mental disease. Science. 1968;160:265–71.
Bland J. The justification for vitamin supplementation. J Holistic Med. 1981;3:12–22.
Motulsky A. Human genetic variation and nutrition. Am J Clin Nutr. 1987;45:1108–13.
Motulsky A. Nutrition and genetic susceptibility to common diseases. Am J Clin Nutr. 1992;55:1244S–5S.
Jabbar A, Yawar A, Waseem S, et al. Vitamin B12 deficiency common in primary hypothyroidism. J Pak Med Assoc. 2008;58(5):258–61.
SH Reuben for the President’s Cancer Panel, US Department of Health and Human Services, National Institutes of Health, National Cancer Institute. Reducing environmental cancer risk. What we can do now. 2010. http://deainfo.nci.nih.gov/advisory/pcp/annualReports/pcp08-09rpt/PCP_Report_08-09_508.pdf.
Sly PD, Carpenter DO, Van den Berg M, et al. Health consequences of environmental exposures: causal thinking in global environmental epidemiology. Ann Glob Health. 2016;82(1):3–9.
González MJ, Miranda-Massari JR, Duconge J, Rodríguez JW, Cintrón K, Berdiel MJ, Rodríguez JR. Nutrigenomics, metabolic correction and disease: the restoration of metabolism as a regenerative medicine perspective. J Restor Med. 2015;4:74–82.
Miranda-Massari JR, Gonzalez MJ, Duconge J, Berdiel M, Alfaro I, Grace K. Metabolic correction therapy: changing the healthcare management paradigm. Integr Food Nutr Metab. 2016;3(2):281–2.
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Gonzalez, M.J. (2020). Metabolic Correction Therapy: A Biochemical–Physiological Mechanistic Explanation of Functional Medicine. In: Noland, D., Drisko, J., Wagner, L. (eds) Integrative and Functional Medical Nutrition Therapy. Humana, Cham. https://doi.org/10.1007/978-3-030-30730-1_7
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