Abstract
Autism has been increasing dramatically since its description by Leo Kanner in 1943. The Centers for Disease Control and Prevention (CDC) in 2018 has identified 1 in 59 children (1 in 37 boys and 1 in 151 girls) has autism spectrum disorder (ASD). Autistic spectrum disorders and ADHD are complex conditions in which nutritional and environmental factors play major roles. It is important to understand how food can have an impact on their current and future health. Appealing food colors stimulate the consumption of different food products. Since 2011, it is evident that dyes are linked to harmful effects in children. Artificial dyes have neurotoxic chemicals that aggravate mental health problems. Many families with autistic children avoid food dyes in their diet in order to avoid behavioral issues. A study reported that there is a correlation between yellow dye and sleep disturbance. Food colors Blue 1 and 2, Green 3, Red 3, Yellow 5 and 6, Citrus Red 2, and Red 40 can trigger many behaviors in most kids. Artificial food color usually contains petroleum and is manufactured in a chemical process that includes formaldehyde, aniline, hydroxides, and sulfuric acids. Most impurities in the food color are in the form of salts or acids. Sometimes lead, arsenic, and mercury may be present as impurities. The U.S. FDA is yet to study the effects of synthetic dyes on behavior in children. A study conducted at Southampton University in England found a link between food dyes and hyperactive behavior in children. The research does not prove that food coloring actually causes autism spectrum disorder, but there seems to be a link. This chapter attempts to provide a broad review of the available literature on food color and the epidemiology, etiology, prevention, and treatment of autistic spectrum disorder.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Volkmar, F. R., & Pauls, D. (2003). Autism. Lancet, 362, 1131–1141.
Jepson, B. (2007). Changing the course of autism (pp. 42–46). Boulder, CO: Sentient Publications Ed..
Lee, Y. S., & Silva, A. J. (2009). The molecular and cellular biology of enhancing cognition. Nature Reviews. Neuroscience, 10(2), 126–140.
Tsanov, M., & Manahan-Vaughn, D. (2008). Synaptic plasticity from visual cortex to hippocampus: System integration in spatial information processing. The Neuroscientist, 14(6), 584–597.
Yerys, B. E., Wallace, G. L., Sokoloff, J. L., Shook, D. A., James, J. D., & Kenworthy, L. (2009). Attention deficit/hyperactivity disorder symptoms moderate cognition and behavior in children with autism spectrum disorders. Autism Research, 2, 322–333.
Eur-Lex. Access to European Union law. Regulation (EC) No. 1333/2008 of the European Parliament and the Council of 16, December 2008 on Food Additives.
Trites, R. L., Tryphonas, H., & Ferguson, H. B. (1980). Diet treatment for hyperactive children with food allergies. In R. M. Knights & D. Bakker (Eds.), Treatment of hyperactive and learning disordered children. Baltimore, MD: University Park Press.
Nigg, J. T., Lewis, K., Edinger, T., & Falk, M. (2012). Meta-analysis of attention deficit/hyperactivity disorder or attention-deficit/hyperactivity disorder symptoms, restriction diet, and synthetic food color additives. Journal of the American Academy of Child and Adolescent Psychiatry, 51, 86–97.
Nigg, J. T., Lewis, K., Tracy Edinger, N. D., & Falk, M. (2012). Meta-analysis of attention-deficit/hyperactivity disorder or attention-deficit/hyperactivity disorder symptoms, restriction diet, and synthetic food color additives. Journal of the American Academy of Child and Adolescent Psychiatry, 51(1), 86–97.
Steven, L. J., Burgess, J. R., Stochelski, M. A., & Kuczek, T. (2015). Amounts of artificial food dyes and added sugars in foods and sweets commonly consumed by children. Clinical Pediatrics (Phila), 54(4), 309–321.
Feingold, B. F. (1973, June 24–28). Adverse reactions to food additives. Presented at The American Medical Association Annual Meeting, Chicago, IL.
McCann, D., Barrett, A., Cooper, A., Crumpler, D., Dalen, L., Grimshaw, K., et al. (2007). Food additives and hyperactive behaviour in 3-year-old and 8/9-year-old children in the community: A randomised, double-blinded, placebo controlled trial. The Lancet, 370, 1560–1567.
Dufault, R., Lukiw, W. J., Crider, R., Schnoll, R., Wallinga, D., & Deth, R. (2012). A macroepigenetic approach to identify factors responsible for the autism epidemic in the United States. Clinical Epigenetics, 4, 6. https://doi.org/10.1186/1868-7083-4-6.40
Grabrucker, A. M. (2014). A role for synaptic zinc in ProSAP/SHANK PSD scaffold malformation in autism spectrum disorders. Developmental Neurobiology, 74(2), 136–146. https://doi.org/10.1002/dneu.22089
Fukada, T., Yamasaki, S., Nishida, K., Murakami, M., & Hirano, T. (2011). Zinc homeostasis and signalling in health and diseases: Zinc signalling. Journal of Biological Inorganic Chemistry, 16, 1123–1134.
Andreini, C., Banci, L., Bertini, I., & Rosato, A. (2006). Counting the zinc-proteins encoded in the human genome. Journal of Proteome Research, 5, 196–201.
Takeda, A. (2000). Movement of zinc and its functional significance in the brain. Brain Research Reviews, 34, 137–148 [International Journal of Environmental Research and Public Health, 10, 6041 (2013)].
Takeda, A., Nakamura, M., Fujii, H., & Tamano, H. (2013). Synaptic Zn (2+) homeostasis and its significance. Metallomics, 5, 417–423.
Prasad, A. S. (2009). Impact of the discovery of human zinc deficiency on health. Journal of the American College of Nutrition, 28, 257–265.
Arnold, L. E., & di Silvestro, R. A. (2005). Zinc in attention-deficit/hyperactivity disorder. Journal of Child and Adolescent Psychopharmacology, 15, 619–627.
di Girolamo, A. M., & Raminez-Zea, M. (2009). Role of zinc in maternal and child mental health. The American Journal of Clinical Nutrition, 89, S940–S945.
Scheplyagina, L. A. (2005). Impact of the mother’s zinc deficiency on the woman’s and new-born’s health status. Journal of Trace Elements in Medicine and Biology, 19, 29–35.
Plum, L. M., Rink, L., & Haase, H. (2010). The essential toxin: Impact of zinc on human health. International Journal of Environmental Research and Public Health, 7, 1342–1365.
Yasuda, H., Yoshida, K., Yasuda, Y., & Tsutsui, T. (2011). Infantile zinc deficiency: Association with autism spectrum disorders. Scientific Reports, 1, 1–5.
Dufault, R., Schnoll, R., Lukiw, W. J., LeBlanc, B., Cornett, C., Patrick, L., et al. (2009). Mercury exposure, nutritional deficiencies and metabolic disruptions may affect learning in children. Behavioral and Brain Functions, 5, 44.
Coyle, P., Philcox, J. C., Carey, L. C., & Rofe, A. M. (2002). Metallothionein: The multipurpose protein. Cellular and Molecular Life Sciences, 59, 627–647.
Shankar, A. H., & Prasad, A. S. (1998). Zinc and immune function: The biological basis of altered resistance to infection. The American Journal of Clinical Nutrition, 68, 447S–463S.
Szczurek, E. I., Bjornsson, C. S., & Taylor, C. G. (2001). Dietary zinc deficiency and repletion modulate metallothionein immunolocalization and concentration in small intestine and liver of rats. The Journal of Nutrition, 131, 2132–2138.
Yorbik, O., Akay, C., Sayal, A., Cansever, A., Sohmen, T., & Cavdar, A. O. (2004). Zinc status in autistic children. Journal of Trace Elements in Experimental Medicine, 17, 101–107.
Faber, S., Zinn, G. M., Kern, J. C., & Kingston, H. M. (2009). The plasma zinc/serum copper ratio as a biomarker in children with autism spectrum disorders. Biomarkers, 14, 171–180.
Yasuda, H., Yoshida, K., Yasuda, Y., & Tsutsui, T. (2011). Infantile zinc deficiency: Association with autism spectrum disorders. Scientific Reports, 1, 129.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Bakthavachalu, P., Kannan, S.M., Qoronfleh, M.W. (2020). Food Color and Autism: A Meta-Analysis. In: Essa, M., Qoronfleh, M. (eds) Personalized Food Intervention and Therapy for Autism Spectrum Disorder Management. Advances in Neurobiology, vol 24. Springer, Cham. https://doi.org/10.1007/978-3-030-30402-7_15
Download citation
DOI: https://doi.org/10.1007/978-3-030-30402-7_15
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-30401-0
Online ISBN: 978-3-030-30402-7
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)