Abstract
Intensively sampled longitudinal data are ubiquitous in modern medicine and pose unique challenges. Future progress in medicine will exploit the fact that multiple physiological measurements can be recorded electronically at arbitrarily high temporal resolution, but novel information systems are needed to create knowledge from these data. In this paper, we present BrainFlux - a novel data warehousing technology that implements a holistic paradigm for storage, summarization and discovery of trends in dynamic data from continuously measured physiological processes. We focus on one specific example of high-resolution longitudinal data: electroencephalographic (EEG) recordings obtained in a large cohort of comatose survivors of cardiac arrest. Post-arrest EEG conveys important clinical and prognostic information to clinicians, but the rigor of prior analyses has been limited by a lack of proper data processing infrastructure. Our EEG data are complemented by a complete set of contemporaneously recorded electronic medical record data, clinical characteristics, and patient outcomes. In this paper, we describe the architecture and performance characteristics of BrainFlux’s scalable data warehousing infrastructure that efficiently stores these data and optimizes information-preserving summarization.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Open platform for analytics, G.T., monitoring: (2013). https://grafana.com/
InfluxData - Time Series Data Products Analytics (2013). https://www.influxdata.com/
Bose, E., et al.: Risk for cardiorespiratory instability following transfer to a monitored step-down unit. Respir. Care 62, 415–422 (2017). https://doi.org/10.4187/respcare.05001
Chen, W.L., Kuo, C.D.: Characteristics of heart rate variability can predict impending septic shock in emergency department patients with sepsis. Acad. Emerg. Med. 14(5), 392–397 (2007)
Elmer, J., Callaway, C.W.: The brain after cardiac arrest. Semin. Neurol. 37, 19–24 (2017)
Elmer, J., et al.: Group-based trajectory modeling of suppression ratio after cardiac arrest. Neurocrit. Care 25(3), 415–423 (2016)
Elmer, J., et al.: Clinically distinct electroencephalographic phenotypes of early myoclonus after cardiac arrest. Ann. Neurol. 80(2), 175–184 (2016)
Gers, F.A., Schmidhuber, J., Cummins, F.: Learning to forget: continual prediction with LSTM (1999)
Nagin, D.S., Odgers, C.L.: Group-based trajectory modeling in clinical research. Annu. Rev. Clin. Psychol. 6, 109–138 (2010)
Nystrom, N.A., Levine, M.J., Roskies, R.Z., Scott, J.: Bridges: a uniquely flexible HPC resource for new communities and data analytics. In: Proceedings of the 2015 XSEDE Conference: Scientific Advancements Enabled by Enhanced Cyberinfrastructure, p. 30. ACM (2015)
Acknowledgement
This work was supported by a grant from UPMC Enterprise, a not for profit entity, to the University of Pittsburgh.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this paper
Cite this paper
Elmer, J., Zhou, Q., Zhang, Y., Yang, F., Zadorozhny, V.I. (2019). BrainFlux: An Integrated Data Warehousing Infrastructure for Dynamic Health Data. In: Welzer, T., et al. New Trends in Databases and Information Systems. ADBIS 2019. Communications in Computer and Information Science, vol 1064. Springer, Cham. https://doi.org/10.1007/978-3-030-30278-8_17
Download citation
DOI: https://doi.org/10.1007/978-3-030-30278-8_17
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-30277-1
Online ISBN: 978-3-030-30278-8
eBook Packages: Computer ScienceComputer Science (R0)